Výsledky vyhledávání - "J. Adrian Copplestone"

Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors

Autor: Jenny A. Orchard, Terry J. Hamblin, Sarah Mould, Rachel E. Ibbotson, Zadie Davis, Peter Thomas, R. Chapman, David Oscier, Sharron Glide, Anne Gardiner, Martin Corcoran, J. Adrian Copplestone

Publikováno v: Blood. 100:1177-1184

This study evaluates the prognostic significance of genetic abnormalities (detected at or shortly after presentation), clinical stage, lymphocyte morphology, CD38 expression, and IGVHgene status in 205 patients with chronic lymphocytic leukemia (B-CL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15f1801e6c12ee3114a386d70ce8f826
https://doi.org/10.1182/blood.v100.4.1177.h81602001177_1177_1184

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ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)

Autor: B. Sean Carey, Archibald G. Prentice, Mark Catherwood, H. Denis Alexander, Sarah J. Richardson, Christine Matthews, Sarah Mould, Joanna Farrugia, Anne Gardiner, David Oscier, J. Adrian Copplestone

Publikováno v: Blood. 107(9)

Molecular markers like IgVH mutational status, chromosomal abnormalities, and CD38 and ZAP-70 expression have prognostic value in B-cell chronic lymphocytic leukemia (B-CLL). These may be pathogenetic because of the coincidental expression of ZAP-70

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586b7cc443d077ca4610ce26786e37d7
https://pubmed.ncbi.nlm.nih.gov/16332969

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Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors

Autor: David G, Oscier, Anne C, Gardiner, Sarah J, Mould, Sharron, Glide, Zadie A, Davis, Rachel E, Ibbotson, Martin M, Corcoran, Robert M, Chapman, Peter W, Thomas, J Adrian, Copplestone, Jenny A, Orchard, Terry J, Hamblin

Publikováno v: Blood. 100(4)

This study evaluates the prognostic significance of genetic abnormalities (detected at or shortly after presentation), clinical stage, lymphocyte morphology, CD38 expression, and IGVH gene status in 205 patients with chronic lymphocytic leukemia (B-C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9275a40804bc1f440317ce030376cd97
https://pubmed.ncbi.nlm.nih.gov/12149185

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Changes in blood supplies, regulations, and transfusion practice

Autor: J. Adrian Copplestone

Publikováno v: BMJ. 330:268-269

Clinicians need to prepare for shortages now In the United Kingdom, we have come to take for granted the supply of blood for transfusion. Changes that might reduce the supply of blood are afoot and are going to affect all clinicians who use blood and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11f126a80c3f752e00c97def43e9704
https://doi.org/10.1136/bmj.330.7486.268

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An 8;14 translocation in a case of plasma cell leukemia

Autor: J. Adrian Copplestone, Sharron Johnson, David Oscier

Publikováno v: Leukemia research. 11(7)

We report a patient with plasma cell leukemia. Chromosomal analysis of bone marrow showed hypodiploidy with a modal number of 32, and a t(8;14). This is only the second reported case of t(8;14) in plasma cell leukemia.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583858d753bd667c4fe8fb528b023ccf
https://pubmed.ncbi.nlm.nih.gov/3613649

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