Zobrazeno 1 - 10
of 14
pro vyhledávání: '"J. Aaron Crapster"'
Autor:
J Aaron Crapster, Paul G Rack, Zane J Hellmann, Austen D Le, Christopher M Adams, Ryan D Leib, Joshua E Elias, John Perrino, Barry Behr, Yanfeng Li, Jennifer Lin, Hong Zeng, James K Chen
Publikováno v:
eLife, Vol 9 (2020)
Mammalian spermiogenesis is a remarkable cellular transformation, during which round spermatids elongate into chromatin-condensed spermatozoa. The signaling pathways that coordinate this process are not well understood, and we demonstrate here that h
Externí odkaz:
https://doaj.org/article/69dfb573f1c24a229b2802b43e4df09a
Autor:
James Vasta, Ani Michaud, Chad Zimprich, Morgan Thomas, Jennifer Wilkinson, J. Aaron Crapster, Matthew Robers
RAF dimer inhibitors offer therapeutic potential in RAF- and RAS-driven cancers. The utility of such drugs is predicated on their capacity to occupy both RAF protomers in the RAS-RAF signaling complex. Here we describe a method to conditionally quant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54bdb971ffe29497abcef42744b9e186
https://doi.org/10.21203/rs.3.rs-2175742/v1
https://doi.org/10.21203/rs.3.rs-2175742/v1
Autor:
Barry Behr, Ryan D. Leib, Austen D Le, Jennifer Lin, John Perrino, Paul G. Rack, Hong Zeng, James K. Chen, Christopher M. Adams, Yanfeng Li, Joshua E. Elias, Zane J Hellmann, J. Aaron Crapster
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Mammalian spermiogenesis is a remarkable cellular transformation, during which round spermatids elongate into chromatin-condensed spermatozoa. The signaling pathways that coordinate this process are not well understood, and we demonstrate here that h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96606763088acf30f71826b8f3673fa1
https://doi.org/10.7554/elife.50209
https://doi.org/10.7554/elife.50209
Autor:
Joshua E. Elias, John Perrino, Austen D Le, Jennifer Lin, James K. Chen, Zane J Hellmann, Ryan D. Leib, Christopher M. Adams, Paul G. Rack, Hong Zeng, Yanfeng Li, Barry Behr, J. Aaron Crapster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27b1fed0e285329d88a27bf427f190e9
https://doi.org/10.7554/elife.50209.sa2
https://doi.org/10.7554/elife.50209.sa2
Autor:
John Perrino, Hong Zeng, Yanfeng Li, Zane J Hellmann, James K. Chen, Barry Behr, Paul G. Rack, J. Aaron Crapster, Jennifer Lin, Joshua E. Elias
Mammalian spermiogenesis is a remarkable cellular transformation, during which round spermatids elongate into chromatin-condensed spermatozoa. The signaling pathways that coordinate this process are not well understood, and we demonstrate here that h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc954ddd746128512aa99cbf631a3e3
https://doi.org/10.1101/703637
https://doi.org/10.1101/703637
Mutations in GLI3, which encodes a transcription factor of the Hedgehog signaling pathway, cause several developmental anomalies linked to inappropriate tissue patterning. Here, we report a novel missense variant in the fifth zinc finger domain of GL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::195ec0235df155896770016b9f7dd4ba
https://europepmc.org/articles/PMC5685880/
https://europepmc.org/articles/PMC5685880/
Publikováno v:
Angewandte Chemie International Edition. 52:5079-5084
foldamers that have been shown to possess numerous biological functions and could find use in a range of fundamental and applied contexts as bio-inspired materials. Peptoids are highly attractive scaffolds for such purposes, as their non-native backb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8a71405d5a538bac48a90e82d8fc2f
https://doi.org/10.1002/anie.201208630
https://doi.org/10.1002/anie.201208630
Publikováno v:
Angewandte Chemie. 125:5183-5188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5701ff0b9569f4c37f5019b20d69ea49
https://doi.org/10.1002/ange.201208630
https://doi.org/10.1002/ange.201208630
Publikováno v:
The Journal of Organic Chemistry. 75:6068-6078
The ability to design foldamers that mimic the defined structural motifs of natural biopolymers is critical for the continued development of functional biomimetic molecules. Peptoids, or oligomers of N-substituted glycine, represent a versatile class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c300e5753e3d0357bf2e4d10947004
https://doi.org/10.1021/jo101075a
https://doi.org/10.1021/jo101075a
Autor:
Vien Nguyen, James K. Chen, Marcel Kool, Volker Hovestadt, Ari J. Firestone, Jun Ni, J. Aaron Crapster, David T.W. Jones, Stefan M. Pfister, Yoon Jae Cho, John K. Mich, Alexander Y. Payumo, Paul G. Rack
Hedgehog (Hh) pathway activation and Gli-dependent transcription play critical roles in embryonic patterning, tissue homeostasis, and tumorigenesis. By conducting a genome-scale cDNA overexpression screen, we have identified the Rho GAP family member
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d37b32d9f1bf40391e28754321e523a
https://europepmc.org/articles/PMC4121843/
https://europepmc.org/articles/PMC4121843/