At-line porosity sensing for non-destructive disintegration testing in immediate release tablets

Autor: Prince Bawuah, Mike Evans, Ard Lura, Daniel J. Farrell, Patrick J. Barrie, Peter Kleinebudde, Daniel Markl, J. Axel Zeitler

Publikováno v: International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100186- (2023)

Fully automated at-line terahertz time-domain spectroscopy in transmission mode is used to measure tablet porosity for thousands of immediate release tablets. The measurements are rapid and non-destructive. Both laboratory prepared tablets and commer

Externí odkaz: https://doaj.org/article/8f9989308d494dcf80b7a71bb5279f75

Formulating a heat- and shear-labile drug in an amorphous solid dispersion: Balancing drug degradation and crystallinity

Autor: Daniel A. Davis, Jr, Dave A. Miller, Supawan Santitewagun, J. Axel Zeitler, Yongchao Su, Robert O. Williams, III

Publikováno v: International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100092- (2021)

We seek to further addresss the questions posed by Moseson et al. regarding whether any residual crystal level, size, or characteristic is acceptable in an amorphous solid dispersion (ASD) such that its stability, enhanced dissolution, and increased

Externí odkaz: https://doaj.org/article/99a533e6ece349858e1b1e00f0811dc7

Predicting capsule fill weight from in-situ powder density measurements using terahertz reflection technology

Autor: Sandra Stranzinger, Eva Faulhammer, Jingyi Li, Runqiao Dong, J. Axel Zeitler, Stefano Biserni, Vittorio Calzolari, Johannes G. Khinast, Daniel Markl

Publikováno v: International Journal of Pharmaceutics: X, Vol 1, Iss , Pp - (2019)

The manufacturing of the majority of solid oral dosage forms is based on the densification of powder. A good understanding of the powder behavior is therefore essential to assure high quality drug products. This is particularly relevant for the capsu

Externí odkaz: https://doaj.org/article/31ed90cbf5c04c77a32c92e36b1ea008

The 2023 Terahertz Science and Technology Roadmap

Autor: Alfred Leitenstorfer, Andrey S Moskalenko, Tobias Kampfrath, Junichiro Kono, Enrique Castro-Camus, Kun Peng, Naser Qureshi, Dmitry Turchinovich, Koichiro Tanaka, Andrea G Markelz, Martina Havenith, Cameron Hough, Hannah J Joyce, Willie J Padilla, Binbin Zhou, Ki-Yong Kim, Xi-Cheng Zhang, Peter Uhd Jepsen, Sukhdeep Dhillon, Miriam Vitiello, Edmund Linfield, A Giles Davies, Matthias C Hoffmann, Roger Lewis, Masayoshi Tonouchi, Pernille Klarskov, Tom S Seifert, Yaroslav A Gerasimenko, Dragan Mihailovic, Rupert Huber, Jessica L Boland, Oleg Mitrofanov, Paul Dean, Brian N Ellison, Peter G Huggard, Simon P Rea, Christopher Walker, David T Leisawitz, Jian Rong Gao, Chong Li, Qin Chen, Gintaras Valušis, Vincent P Wallace, Emma Pickwell-MacPherson, Xiaobang Shang, Jeffrey Hesler, Nick Ridler, Cyril C Renaud, Ingmar Kallfass, Tadao Nagatsuma, J Axel Zeitler, Don Arnone, Michael B Johnston, John Cunningham

Publikováno v: Journal of Physics D: Applied Physics
Leitenstorfer, A, Moskalenko, A S, Kampfrath, T, Kono, J, Castro-Camus, E, Peng, K, Qureshi, N, Turchinovich, D, Tanaka, K, Markelz, A, Havenith, M, Hough, C, Joyce, H, Padilla, W, Zhou, B, Kim, K-Y, Zhang, X-C, Jepsen, P U, Dhillon, S, MIRIAM, SERENA VITIELLO, Linfield, E H, Hoffmann, M, Lewis, R, Tonouchi, M, Klarskov, P, Seifert, T, Gerasimenko, Y, Mihailovic, D D, Huber, R, Boland, J, Mitrofanov, O, Dean, P, Ellison, B, Huggard, P, Rea, S, Walker, C, Leisawitz, D, Gao, J R, Li, C, Chen, Q, Valusis, G, Wallace, V P, He, Y, Shang, X, Hesler, J, Ridler, N, Renaud, C, Kallfass, I, Nagatsuma, T, Zeitler, A, Arnone, D, Johnston, M B & Cunningham, J 2023, ' The 2023 Terahertz Science and Technology Roadmap ', Journal of Physics D: Applied Physics, vol. 56, no. 22, 223001 . https://doi.org/10.1088/1361-6463/acbe4c
Leitenstorfer, A, Moskalenko, A S, Kampfrath, T, Kono, J, Castro-Camus, E, Peng, K, Qureshi, N, Turchinovich, D, Tanaka, K, Markelz, A G, Havenith, M, Hough, C, Joyce, H J, Padilla, W J, Zhou, B, Kim, K Y, Zhang, X C, Jepsen, P U, Dhillon, S, Vitiello, M, Linfield, E, Davies, A G, Hoffmann, M C, Lewis, R, Tonouchi, M, Klarskov, P, Seifert, T S, Gerasimenko, Y A, Mihailovic, D, Huber, R, Boland, J L, Mitrofanov, O, Dean, P, Ellison, B N, Huggard, P G, Rea, S P, Walker, C, Leisawitz, D T, Gao, J R, Li, C, Chen, Q, Valušis, G, Wallace, V P, Pickwell-MacPherson, E, Shang, X, Hesler, J, Ridler, N, Renaud, C C, Kallfass, I, Nagatsuma, T, Zeitler, J A, Arnone, D, Johnston, M B & Cunningham, J 2023, ' The 2023 terahertz science and technology roadmap ', Journal of Physics D: Applied Physics, vol. 56, no. 22, 223001 . https://doi.org/10.1088/1361-6463/acbe4c

Funder: Alexander von Humboldt Foundation
Funder: Experienced Researcher Fellowship
Funder: DFG Collaborative
Funder: PAPIIT
Funder: Danish National Research Foundation
Funder: JSPS
Funder: STFC Centre for Instrumentatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf90c7e7a566bbf609cf51df7c44819
https://hdl.handle.net/21.11116/0000-000C-C5A7-921.11116/0000-000C-F82C-C

Detecting Crystallinity Using Terahertz Spectroscopy in 3D Printed Amorphous Solid Dispersions

Autor: Supawan Santitewagun, Rishi Thakkar, J. Axel Zeitler, Mohammed Maniruzzaman

Publikováno v: Molecular Pharmaceutics. 19:2380-2389

This study demonstrates the applicability of terahertz time-domain spectroscopy (THz-TDS) in evaluating the solid-state of the drug in selective laser sintering-based 3D printed dosage forms. Selective laser sintering is a powder bed-based 3D printin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a6cffcf82be434e62adcca12ea0361
https://doi.org/10.1021/acs.molpharmaceut.2c00163