Zobrazeno 1 - 10
of 26
pro vyhledávání: '"J. A. Totaro"'
Autor:
J. A. Totaro, Roger M. Freidinger, Mark G. Bock, Gretchen S. Young, Bradley V. Clineschmidt, Douglas J. Pettibone, Peter D. Williams, Richard W. Ransom, D. F. Veber, E V Lis
Publikováno v:
European Journal of Pharmacology. 196:233-237
From a series of potent cyclic hexapeptide oxytocin (OT) antagonists, a compound that exhibited significant bradykinin (BK) agonist activity was identified. L-366,811 (cyclo[L-proline-D-tryptophan-L-isoleucine-D-pipecolic acid-L-piperazine-2-carboxyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53b41c1709fc6dceb1a1ad573c09cc6
https://doi.org/10.1016/0014-2999(91)90435-s
https://doi.org/10.1016/0014-2999(91)90435-s
Autor:
Michael Williams, Bradley V. Clineschmidt, J. A. Totaro, Patricia R. Bunting, John J. Witoslawski, Edwin A. Risley
Publikováno v:
Drug Development Research. 2:147-163
MK-801 was evaluated in rats for “antipunishment” and “anticonflict” activity in two procedures: (1) A conditioned emotional response (CER) test involving the suppression of lever-pressing by unaviodable shock and (2) a simple conflict test i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54a1a1791c595f50b18ddaddac5a8a4d
https://doi.org/10.1002/ddr.430020205
https://doi.org/10.1002/ddr.430020205
Publikováno v:
European Journal of Pharmacology. 35:211-214
A single oral dose of 15 mg/kg of fenfluramine reduced the level of serotonin in rat brain to 48, 51 and 63% of control at 1, 15 and 30 days, respectively, after administration. 3 mg/kg p.o. of the drug caused a smaller but significant diminution in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e6368a1a4b91c1ea75b4e223666298
https://doi.org/10.1016/0014-2999(76)90318-6
https://doi.org/10.1016/0014-2999(76)90318-6
Autor:
Anthony G. Zacchei, Bradley V. Clineschmidt, Jodie C. McGuffin, A. Barbara Pflueger, Theodore I. Wishousky, J. A. Totaro
Publikováno v:
Annals of the New York Academy of Sciences. 305:222-241
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab7b242d109238e92e7148781930ebd
https://doi.org/10.1111/j.1749-6632.1978.tb31526.x
https://doi.org/10.1111/j.1749-6632.1978.tb31526.x
A 5-HYDROXYTRYPTAMINE-LIKE MODE OF ANORECTIC ACTION FOR 6-CHLORO-2-[1-PIPERAZINYL]-PYRAZINE (MK-212)
Publikováno v:
British Journal of Pharmacology. 62:579-589
The mechanism of the reduction in food consumption elicited by 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) administered systemically was investigated in the rat. (+/-)-Fenfluramine and (+)-amphetamine were included in some studies for comparative pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1679d7ec0e39ddab62f19568feedc7
https://doi.org/10.1111/j.1476-5381.1978.tb07765.x
https://doi.org/10.1111/j.1476-5381.1978.tb07765.x
Autor:
J. A. Totaro, Walfred S. Saari, Emlen L. Cresson, George G. Yarbrough, Michael Williams, James P. Springer, Yung C. Lee, David W. Cochran
Publikováno v:
Journal of Medicinal Chemistry. 26:564-569
Chloro- and methyl-substituted 10H-pyrazino[2,3-b][1,4]benzothiazines were prepared and their structures determined by 13C NMR and X-ray crystallographic analysis. Alkylation afforded the 10-[3-(dimethylamino)-1-propyl] derivatives, which were compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33a287a977f68efd993604e4cddce84c
https://doi.org/10.1021/jm00358a020
https://doi.org/10.1021/jm00358a020
Publikováno v:
Journal of Pharmacy and Pharmacology. 27:780-782
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd60b3996826da44e3d69a8e2b716538
https://doi.org/10.1111/j.2042-7158.1975.tb09402.x
https://doi.org/10.1111/j.2042-7158.1975.tb09402.x
Autor:
W C, Randall, P S, Anderson, E L, Cresson, C A, Hunt, T F, Lyon, K E, Rittle, D C, Remy, J P, Springer, J M, Hirshfield, K, Hoogsteen, M, Williams, E A, Risley, J A, Totaro
Publikováno v:
Journal of medicinal chemistry. 22(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910ba9dde6b0777d70afcec2eeb26f40
https://pubmed.ncbi.nlm.nih.gov/41950
https://pubmed.ncbi.nlm.nih.gov/41950
Publikováno v:
Scopus-Elsevier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089b40c9e2b9e4adec782cc1c71ff0c1
https://pubmed.ncbi.nlm.nih.gov/26778
https://pubmed.ncbi.nlm.nih.gov/26778
Publikováno v:
Neuropharmacology. 14(4)
Fenfluramine, administered to rats at anorectic dose levels, reduced open field activity and enhanced confinement motor activity, demonstrating the mixed depressant and stimulant characteristics of the compound. Studies designed to elucidate the mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6eeb00e9bcf1a385e451b7977b8aab1
https://pubmed.ncbi.nlm.nih.gov/124023
https://pubmed.ncbi.nlm.nih.gov/124023