Zobrazeno 1 - 10
of 64
pro vyhledávání: '"J. A. Timbrell"'
Publikováno v:
Reproduction. 112:325-330
The testis synthesizes creatine from both arginine and glycine precursors, but when rat testicular tissue is separated into seminiferous tubules and interstitial cells, creatine synthesis occurs only in the tubular fraction. The purpose of the work p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf04b8d04cce0a9e4f344510a4fdf8a
https://doi.org/10.1530/jrf.0.1120325
https://doi.org/10.1530/jrf.0.1120325
Publikováno v:
Toxicology in Vitro. 11:217-227
Studies have been carried out in rats in vivo and in isolated hepatocytes from the same strain of rat in vitro using the hepatotoxicant hydrazine as a model compound. These studies have shown that a number of biochemical changes occur and are measura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3105abb7da252f44519cca0f3c3e2e01
https://doi.org/10.1016/s0887-2333(97)00012-x
https://doi.org/10.1016/s0887-2333(97)00012-x
Autor:
C. Dilworth, J. A. Timbrell
Publikováno v:
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 3(3)
Stress proteins have been proposed as markers of toxicity. This study investigated the sensitivity and specificity of stress proteins as markers of toxicity in primary hepatocyte cultures following exposure to two compounds, hydrazine and cadmium chl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75180a5da2f5d00391d4d87ea43fbde5
https://pubmed.ncbi.nlm.nih.gov/23899329
https://pubmed.ncbi.nlm.nih.gov/23899329
Publikováno v:
Comparative Haematology International. 6:232-236
Studies in rats in vivo and in isolated hepatocytes from the same species and strain of animal in vitro with the hepatotoxicant hydrazine have shown that despite measuring the same parameters in each system, the effects do not always show a quantitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72761f2095901ee095f01cf912c42636
https://doi.org/10.1007/bf00378116
https://doi.org/10.1007/bf00378116
Publikováno v:
Comparative Haematology International. 5:112-119
We have shown that urinary taurine and creatine may be used as biomarkers of pathological and biochemical lesions. Detection of changes in the urinary concentration of these two low-molecular-weight metabolites indicates biochemical lesions which may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4a3fa8a3b09b28cf662d5df6668461e
https://doi.org/10.1007/bf00638929
https://doi.org/10.1007/bf00638929
Autor:
J. A. Timbrell, Andrew M. Jenner
Publikováno v:
Xenobiotica. 25:599-609
1. It has been demonstrated that hydrazine is metabolized by rat liver enzymes located in the microsomal fraction. This metabolism was reduced in the absence of oxygen or NADPH and was increased by NADH in the presence of NADPH. 2. Microsomal enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f295cb074ee57ce6dadb9cd797c267a
https://doi.org/10.3109/00498259509061878
https://doi.org/10.3109/00498259509061878
Autor:
J. A. Timbrell, Andrew M. Jenner
Publikováno v:
Archives of Toxicology. 68:349-357
Hydrazine hepatotoxicity in vivo, as manifested by triglyceride accumulation, depletion of ATP and reduced glutathione (GSH) was shown to be dose related. The effect of pretreatment of rats with various inhibitors and inducers of cytochrome P450 on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a77b64c664650a9b1564b82bedbc9b
https://doi.org/10.1007/s002040050081
https://doi.org/10.1007/s002040050081
Autor:
J. A. Timbrell, Andrew M. Jenner
Publikováno v:
Archives of Toxicology. 68:240-245
A single dose of hydrazine (3 mg.kg-1 i.p.) caused hepatic accumulation of triglycerides and depletion of ATP in rats after 9 h. Repeated exposure of rats to hydrazine (approximately equal to 2.5 mg.kg-1 per day) for 10 days resulted in depletion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d741277d1316bcf3a1373f1e6780ab98
https://doi.org/10.1007/s002040050063
https://doi.org/10.1007/s002040050063
Publikováno v:
Toxicology. 77:7-20
Treatment of rats with beta-alanine increases the urinary taurine levels and markedly reduces the concentration of taurine in the liver. Dosing with carbon tetrachloride (CCl4) during treatment with beta-alanine results in a marked decrease in urinar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabddfe9032a76543e336a7c818ba1c5
https://doi.org/10.1016/0300-483x(93)90133-d
https://doi.org/10.1016/0300-483x(93)90133-d
Publikováno v:
Archives of Toxicology. 66:660-668
Using isolated rat hepatocytes the biochemical effects of hydrazine have been investigated using both conventional assay techniques and high resolution proton NMR. High resolution proton NMR revealed that hydrazine caused a significant increase in al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a427c4ec72d88cf28b1b5205f034ae
https://doi.org/10.1007/bf01981506
https://doi.org/10.1007/bf01981506