Zobrazeno 1 - 10
of 33
pro vyhledávání: '"J. A. St. George"'
Autor:
Mark V Avdalovic, Edward S. Schelegle, Matt J. Herring, J. A. St. George, Lei F. Putney, Lisa A. Miller, Dallas M. Hyde
Publikováno v:
Toxicology and applied pharmacology, vol 283, iss 1
In rhesus macaques, previous studies have shown that episodic exposure to allergen alone or combined with ozone inhalation during the first 6 months of life results in a condition with many of the hallmarks of asthma. This exposure regimen results in
Publikováno v:
Combustion Theory and Modelling. 10:907-926
A general approach is described for modelling problems that involve heat and mass transfer in coal, such as spontaneous combustion. It is based on the TOUGH2 code, which is a general-purpose simulator for modelling multi-component, multi-phase, non-i
Publikováno v:
Mineralogical Magazine. 67:665-670
Adiabatic self-heating tests were carried out on five New Zealand coal samples ranging in rank from lignite to high-volatile bituminous. Kinetic parameters of oxidation were obtained from the self-heating curves assuming Arrhenius behaviour. The acti
Autor:
J A St George
Publikováno v:
Gene Therapy. 10:1135-1141
In September 1999, the perceptions of the use of adenoviral (Ad) vectors for gene therapy were altered when a patient exposed via the hepatic artery to a high dose of adenoviral vector succumbed to the toxicity related to vector administration. Appro
Autor:
M. A. Barakat, J. D. St George
Publikováno v:
International Journal of Coal Geology. 45:105-113
Volumetric shrinkage associated with gas desorption from the coal matrix has a significant influence on the stress field. This is of particular practical importance around headings in underground coal mining, as it controls the permeability to gases
Autor:
Joseph Zabner, Alan E. Smith, M P Smith, Cathleen Sookdeo, Samuel C. Wadsworth, D Armentano, C Sacks, Richard J. Gregory, J A St George
Publikováno v:
Journal of Virology. 71:2408-2416
The utility of adenovirus vectors for gene therapy is limited by the transience of expression that has been observed in various in vivo models. Immunological responses to viral targets can eliminate transduced cells and cause the loss of transgene ex
Autor:
Charles G. Plopper, J. A. St George, Alan R. Buckpitt, Reen Wu, Wellington V. Cardoso, Kent E. Pinkerton
Publikováno v:
Chest. 101:2S-5S
Tracheobronchial airway development begins prenatally and continues for an extended period of postnatal life. In adults, the organization of tracheobronchial airway epithelium is highly complex and variable both within the airway tree of a single spe
Autor:
J A St George, Richard J. Gregory, Alan E. Smith, RJ Noelle, Abraham Scaria, Johanne Kaplan, Sam Wadsworth
Publikováno v:
Gene therapy. 4(6)
Adenoviral vectors have been used successfully to transfer the human CFTR cDNA to respiratory epithelium in animal models and to CF patients in vivo. However, studies done primarily in mice, indicate that present vector systems have limitations. Amon
Autor:
J A, St George, S E, Pennington, J M, Kaplan, P A, Peterson, L J, Kleine, A E, Smith, S C, Wadsworth
Publikováno v:
Gene therapy. 3(2)
We have assessed the safety and efficacy of repeated adenovirus vector administration by exposing the left caudal lung lobe of rhesus monkeys to as many as 17 exposures of Ad2/CFTR-2. After nine doses of either 3 x 10(9) or 3 x 10(10) infectious unit
Publikováno v:
Inflammation. 17(6)
The respiratory epithelium is often exposed to oxidant gases, including ozone from photochemical smog and toxic oxygen metabolites released from neutrophils recruited in conditions of airway inflammation. We evaluated DNA single strand break formatio