Zobrazeno 1 - 10
of 19
pro vyhledávání: '"J. A. Poiley"'
Publikováno v:
Arzneimittel-Forschung. 47(3)
An aqueous mistletoe extract (AME, the active principle of Lektinol) was investigated for its genotoxic potential in a wide range of in vitro studies, according to the actual international standard guidelines. Gene mutation tests on bacteria and mamm
Publikováno v:
Developments in biological standardization. 76
An important aspect of the virological assessment of cell substrates used to produce biologicals is their retroviral status. In this presentation we will attempt to document some of the practical experiences of industry when testing cell substrates f
Publikováno v:
Arzneimittel-Forschung. 41(10)
Single oral or intravenous doses of the expressed juice of Echinacea purpurea (EP) proved virtually non-toxic to rats and mice. After 4 weeks of oral administration in doses amounting to many times the human therapeutic dose laboratory tests and necr
Autor:
J A, Poiley
Publikováno v:
Bioprocess technology. 10
The possibility for viral contamination exists in established cultures as well as in primary cultures. The use of established genetically engineered cultures in the production of biologicals for human use requires that these cultures be monitored for
Publikováno v:
Progress in clinical and biological research.
Publikováno v:
In Vitro. 17:811-815
To estimate worker exposures to, and environmental contamination from, test chemicals and organic solvents used in an in vitro assay to assess the carcinogenic potential of chemicals, sodium fluorescein, a noncarcinogenic fluorescent material, was di
Publikováno v:
Carcinogenesis. 1:323-328
When benzo(a)pyrene was used to evaluate the transformability of 129 hamster embryo cell preparations from pooled or individual embryos, approximately 50% of the cultures were transformable. A transformable and a non-transformable cell culture were f
Publikováno v:
In Vitro. 15:730-735
Eighteen lots of fetal bovine serum were tested for their ability to support clonal growth and 3-methylcholanthrene-induced morphological transformation of hamster embryo cells in vitro. Most of them supported cloning efficiencies of over 11%. Howeve
Publikováno v:
Teratogenesis, Carcinogenesis, and Mutagenesis. 5:405-413
The carcinogens N-2-acetylaminofluorene (AAF) and diethylnitrosamine (DEN) often give negative results when tested in the Fischer rat embryo cell survival assay with the standard single 72-hour regimen, whereas another carcinogen, benzo(a)pyrene [B(a
Publikováno v:
Annals of the New York Academy of Sciences. 407