WHIM Syndrome-linked CXCR4 mutations drive osteoporosis

Autor: Adrienne Anginot, Julie Nguyen, Zeina Abou Nader, Vincent Rondeau, Amélie Bonaud, Maria Kalogeraki, Antoine Boutin, Julia P. Lemos, Valeria Bisio, Joyce Koenen, Lea Hanna Doumit Sakr, Amandine Picart, Amélie Coudert, Sylvain Provot, Nicolas Dulphy, Michel Aurrand-Lions, Stéphane J. C. Mancini, Gwendal Lazennec, David H. McDermott, Fabien Guidez, Claudine Blin-Wakkach, Philip M. Murphy, Martine Cohen-Solal, Marion Espéli, Matthieu Rouleau, Karl Balabanian

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Abstract WHIM Syndrome is a rare immunodeficiency caused by gain-of-function CXCR4 mutations. Here we report a decrease in bone mineral density in 25% of WHIM patients and bone defects leading to osteoporosis in a WHIM mouse model. Imbalanced bone ti

Externí odkaz: https://doaj.org/article/71e743108c284ff4a7d508b10f487735

Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid Leukaemia

Autor: Julien M. P. Grenier, Céline Testut, Cyril Fauriat, Stéphane J. C. Mancini, Michel Aurrand-Lions

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

In the bone marrow (BM) of adult mammals, haematopoietic stem cells (HSCs) are retained in micro-anatomical structures by adhesion molecules that regulate HSC quiescence, proliferation and commitment. During decades, researchers have used engraftment

Externí odkaz: https://doaj.org/article/71651b1cfd9d47078cabce2a3a0be5cf

J. M. Mancini

Autor: J. M. Mancini

Publikováno v: Panorama, Vol 6, Iss 1 (2020)

Externí odkaz: https://doaj.org/article/d5879a80cdbb444d968bd9961bbf1d41

Flow Cytometry Analysis of Mouse Hematopoietic Stem and Multipotent Progenitor Cells

Autor: Michel Aurrand-Lions, Julien M. P. Grenier, Stéphane J. C. Mancini, Marjorie C. Delahaye

Publikováno v: Bone Marrow Environment
Bone Marrow Environment, 2308, Springer US, pp.73-81, 2021, Methods in Molecular Biology, ⟨10.1007/978-1-0716-1425-9_6⟩
Methods in Molecular Biology ISBN: 9781071614242

Flow cytometry has been widely used to detect a single event by means of multiparametric fluorescence measurements. Here we describe a method to analyze subsets of hematopoietic stem and progenitor cells isolated from long bones of mice. We further s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29873b6158744dc8a2a1d10c7653647
https://hal-amu.archives-ouvertes.fr/hal-03622577

Toward Therapeutic Targeting of Bone Marrow Leukemic Niche Protective Signals in B-Cell Acute Lymphoblastic Leukemia

Autor: Jeoffrey Pelletier, Stéphane J. C. Mancini, Michel Aurrand-Lions, Kaoutar-Insaf Salem, Marjorie C. Delahaye

Publikováno v: Frontiers in Oncology
Frontiers in Oncology, Frontiers, 2021, 10, ⟨10.3389/fonc.2020.606540⟩
Frontiers in Oncology, Vol 10 (2021)
Frontiers in Oncology, 2021, 10, ⟨10.3389/fonc.2020.606540⟩

B-cell acute lymphoblastic leukemia (B-ALL) represents the malignant counterpart of bone marrow (BM) differentiating B cells and occurs most frequently in children. While new combinations of chemotherapeutic agents have dramatically improved the prog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abfd61ff34975e7eaaed1073507e207
https://hal.archives-ouvertes.fr/hal-03155760