Zobrazeno 1 - 8
of 8
pro vyhledávání: '"J. A. Landro"'
Autor:
Rhonda B. Levin, Luc J. Farmer, Robert B. Perni, Joseph L. Kim, Janos Pitlik, B. Govinda Rao, J. A. Landro, Wayne C. Schairer, Roger D. Tung, Shawn D. Britt, Cynthia A. Gates, David D. Deininger, John A. Thomson, John H. Van Drie, Lawrence F. Courtney, John Court, Ethan O'malley, Scott L. Harbeson, Yu-Ping Luong, Yunyi Wei
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4059-4063
Tetrapeptide-based peptidomimetic compounds have been shown to effectively inhibit the hepatitis C virus NS3·4A protease without the need of a charged functionality. An aldehyde is used as a prototype reversible electrophilic warhead. The SAR of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91046b82077f4245c43e468a535b331b
https://doi.org/10.1016/j.bmcl.2003.08.050
https://doi.org/10.1016/j.bmcl.2003.08.050
Autor:
J A, Landro, I C, Taylor, W G, Stirtan, D G, Osterman, J, Kristie, E J, Hunnicutt, P M, Rae, P M, Sweetnam
Publikováno v:
Journal of pharmacological and toxicological methods. 44(1)
Over the past decade, high throughput screening (HTS) has become the focal point for discovery programs within the pharmaceutical industry. The role of this discipline has been and remains the rapid and efficient identification of lead chemical matte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4082066035905810b6213fafe3a7a68
https://pubmed.ncbi.nlm.nih.gov/11274895
https://pubmed.ncbi.nlm.nih.gov/11274895
Autor:
Scott L. Harbeson, Morgenstern Kurt A, David J. Livingston, Ethan O'malley, Yu Ping C. Luong, Scott A. Raybuck, Govinda Rao, J. A. Landro
Publikováno v:
Biochemistry. 36(31)
Infection by hepatitis C viruses (HCVs) is a serious medical problem with no broadly effective treatment available for the progression of chronic hepatitis. The catalytic activity of a viral serine protease located in the N-terminal one-third of nons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e81c6684fdd56d81b1a3cdf2e6dcad
https://pubmed.ncbi.nlm.nih.gov/9235976
https://pubmed.ncbi.nlm.nih.gov/9235976
Autor:
Y. Gu, J. A. Landro, Chao Lin, John A. Thomson, Kathy Hsiao, Michael S.-S. Su, Morgenstern Kurt A
The hepatitis C virus (HCV) nonstructural 3 protein (NS3) is a 70-kDa multifunctional enzyme with three known catalytic activities segregated in two somewhat independent domains. The essential machinery of a serine protease is localized in the N-term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067ae5f2316f152d3817eae8eb33acfb
https://europepmc.org/articles/PMC191527/
https://europepmc.org/articles/PMC191527/
Autor:
J. A. Landro, Charles M. Rice, Paul R. Caron, Stephen P. Chambers, William Markland, Christopher A. Lepre, Morgenstern Kurt A, Chao Lin, Scott L. Harbeson, Murcko Mark A, Ted Fox, Maureen D. Dwyer, John A. Thomson, Joseph L. Kim, Ethan O'malley
Publikováno v:
Cell. 87(2)
An estimated 1% of the global human population is infected by hepatitis C viruses (HCVs), and there are no broadly effective treatments for the debilitating progression of chronic hepatitis C. A serine protease located within the HCV NS3 protein proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6786a8c6233122fb0de74cfab9dda7c6
https://pubmed.ncbi.nlm.nih.gov/8861917
https://pubmed.ncbi.nlm.nih.gov/8861917
Autor:
J A, Landro, P, Schimmel
Publikováno v:
The Journal of biological chemistry. 269(32)
We present evidence that zinc bound near the C terminus of a long tRNA synthetase polypeptide, and at a location far in the sequence from the catalytic domain, is needed to sustain cell growth and is, therefore, essential for enzyme function. Several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::103e50848ce6be057b3406ce32d4d83f
https://pubmed.ncbi.nlm.nih.gov/8051111
https://pubmed.ncbi.nlm.nih.gov/8051111
Publikováno v:
Sangre. 39(3)
To evaluate the efficacy of the combination, alpha-interferon (IFN)-hydroxyurea (HU) in the treatment of patients with Philadelphia positive chronic myelogenous leukaemia (Ph'-CML).A prospective study was started in 1988 in which 30 patients with chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87dcc1f1bddee0aace7e19f4ac17bc89
https://pubmed.ncbi.nlm.nih.gov/7940047
https://pubmed.ncbi.nlm.nih.gov/7940047
Autor:
H. Kasdorf, J. Tanzer, R. Ferrando, I. Rodriguez, J. Di Landro, R. De Bellis, M. R. Boulard, M. Ferrari, C. M. Sanguinett
Publikováno v:
British Journal of Haematology. 42:35-39
Serum copper levels (SCL) which are concomitantly related to red blood cell free copper are significantly increased in some malignant lymphomas in the phase of activity. This results in a profound inhibition of red cell key glycolytic enzymes, hexoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a3c3dc0801278f110e152bb18dd07e
https://doi.org/10.1111/j.1365-2141.1979.tb03695.x
https://doi.org/10.1111/j.1365-2141.1979.tb03695.x