Výsledky vyhledávání - "J. A. Jakubowski"

Akademický článek

Induction of Diabetes Abolishes the Antithrombotic Effect of Clopidogrel in Apolipoprotein E–Deficient Mice

Autor: A. Sugidachi, K. Ohno, J. A. Jakubowski, Y. Ito, A. Tomizawa, M. Mizuno

Publikováno v: TH Open, Vol 01, Iss 02, Pp e92-e100 (2017)

Abstract Patients with acute coronary syndrome with diabetes mellitus (DM) exhibit an impaired platelet inhibitory response to clopidogrel which is only partially understood. DM was induced by the administration of streptozotocin (STZ) to 9-week-old

Externí odkaz: https://doaj.org/article/c06e752b664b4cf485fb997b7f037cb2

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The reversible P2Y antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function

Autor: N L, Dovlatova, J A, Jakubowski, A, Sugidachi, S, Heptinstall

Publikováno v: Journal of thrombosis and haemostasis : JTH. 6(7)

Agents that act as antagonists at P2Y(12) ADP receptors on platelets are in use (clopidogrel), and in development for use (cangrelor and prasugrel), in patients with cardiovascular disease. Cangrelor is a direct-acting reversible antagonist being dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c492818a25013bd67604e3b6b04a3fb5
https://pubmed.ncbi.nlm.nih.gov/18485086

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Inhibition of coagulation and thrombin-induced platelet activities by a synthetic dodecapeptide modeled on the carboxy-terminus of hirudin

Autor: J A, Jakubowski, J M, Maraganore

Publikováno v: Blood. 75:399-406

A synthetic, tyrosine-sulfated, dodecapeptide (BG8865) modeled on residues 53–64 of hirudin was found to elevate the activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) of human plasma in a dose-dependent man

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dfe06dad77a2c34cd57a9d631380aa0
https://doi.org/10.1182/blood.v75.2.399.bloodjournal752399

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Current Antiplatelet Therapy

Autor: H. F. Weisman, R. E. Jordan, J. A. Jakubowski

Publikováno v: Antithrombotics ISBN: 9783642641909

Initially considered circulating cell fragments, the blood platelet is now recognized to play vital roles in both hemostasis and thrombosis. Recognition of its role in arterial thrombosis has, in part, been driven by the study of the effects of plate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4854e07397a09fd9104f7e9fd04994a8
https://doi.org/10.1007/978-3-642-59942-2_7

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p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2

Autor: R M, Kramer, E F, Roberts, S L, Um, A G, Börsch-Haubold, S P, Watson, M J, Fisher, J A, Jakubowski

Publikováno v: The Journal of biological chemistry. 271(44)

The Ca2+-sensitive 85-kDa cytosolic phospholipase A2 (cPLA2) is responsible for thrombin-stimulated mobilization of arachidonic acid for the synthesis of thromboxane A2 in human platelets. We have previously shown that thrombin activates p38 kinase,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7c79793c627d48baacede24fd8f277bb
https://pubmed.ncbi.nlm.nih.gov/8910365

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