Zobrazeno 1 - 10
of 1 404
pro vyhledávání: '"J. A. Jacobs"'
Autor:
Shiu Yeung Lam, Ruben van der Lugt, Aurora Cerutti, Zeliha Yalçin, Alexander M. Thouin, Marco Simonetta, Jacqueline J. L. Jacobs
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Appropriate repair of damaged DNA and the suppression of DNA damage responses at telomeres are essential to preserve genome stability. DNA damage response (DDR) signaling consists of cascades of kinase-driven phosphorylation events, fine-tun
Externí odkaz:
https://doaj.org/article/b74aa4e21a574c729c4054e113063d0e
Autor:
Zeliha Yalçin, Shiu Yeung Lam, Marieke H. Peuscher, Jaco van der Torre, Sha Zhu, Prasanna V. Iyengar, Daniel Salas-Lloret, Inge de Krijger, Nathalie Moatti, Ruben van der Lugt, Mattia Falcone, Aurora Cerutti, Onno B. Bleijerveld, Liesbeth Hoekman, Román González-Prieto, Jacqueline J. L. Jacobs
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Maintenance of genome integrity requires tight control of DNA damage response (DDR) signalling and repair, with phosphorylation and ubiquitination representing key elements. How these events are coordinated to achieve productive DNA repair r
Externí odkaz:
https://doaj.org/article/5904fb9cf15e4ea0bcf5f618e256368f
Autor:
Annemie M W J Schols, Anke H Maitland-van der Zee, Joop P van den Bergh, Sebastiaan Holverda, Esther J Nossent, Els J M Weersink, Marianne A van de Pol, Firdaus A A Mohamed Hoesein, Lisanne T Schuurman, Ivo van der Lee, Jelle M Blankestijn, Mahmoud I Abdel-Aziz, Nadia Baalbaki, Somayeh Bazdar, Inés Beekers, Rosanne J H C G Beijers, Lizan D Bloemsma, Merel E B Cornelissen, Debbie Gach, Laura Houweling, John J L Jacobs, Reneé Jonker, Paulien M A Linders, Lieke C E Noij, Daphne W Schaminee, Brigitte Sondermeijer, J J Miranda Geelhoed, Yolanda de Wit-van Wijck
Publikováno v:
BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)
Background Four months after SARS-CoV-2 infection, 22%–50% of COVID-19 patients still experience complaints. Long COVID is a heterogeneous disease and finding subtypes could aid in optimising and developing treatment for the individual patient.Meth
Externí odkaz:
https://doaj.org/article/08cab7016402442e9e9b869081c263bd
Autor:
H. Proulx, J. M. Jacobs, E. A. Burakowski, E. Cho, A. G. Hunsaker, F. B. Sullivan, M. Palace, C. Wagner
Publikováno v:
The Cryosphere, Vol 17, Pp 3435-3442 (2023)
The accuracy and precision of snow depth measurements depend on the measuring device and the conditions of the site and snowpack in which it is being used. This study compares collocated snow depth measurements from a magnaprobe snow depth probe and
Externí odkaz:
https://doaj.org/article/58a123fee0574b6c9309a3b9eae40ad9
Autor:
Daria Shevtsova, Anam Ahmed, Iris W A Boot, Carmen Sanges, Michael Hudecek, John J L Jacobs, Simon Hort, Hubertus J M Vrijhoef
Publikováno v:
JMIR Human Factors, Vol 11, p e47031 (2024)
BackgroundArtificial intelligence (AI)–powered technologies are being increasingly used in almost all fields, including medicine. However, to successfully implement medical AI applications, ensuring trust and acceptance toward such technologies is
Externí odkaz:
https://doaj.org/article/dbd626d0294048c38dce54fea962e7ca
Publikováno v:
Hydrology and Earth System Sciences, Vol 26, Pp 5721-5735 (2022)
Seasonal snow is an essential component of regional and global water and energy cycles, particularly in snow-dominant regions that rely on snowmelt for water resources. Land surface models (LSMs) are a common approach for developing spatially and tem
Externí odkaz:
https://doaj.org/article/2281ba0c5f184f16985ba84ec3fddc35
Autor:
Niklas Bäckel, Simon Hort, Tamás Kis, David F. Nettleton, Joseph R. Egan, John J. L. Jacobs, Dennis Grunert, Robert H. Schmitt
Publikováno v:
Frontiers in Molecular Medicine, Vol 3 (2023)
This paper discusses the challenges of producing CAR-T cells for cancer treatment and the potential for Artificial Intelligence (AI) for its improvement. CAR-T cell therapy was approved in 2018 as the first Advanced Therapy Medicinal Product (ATMP) f
Externí odkaz:
https://doaj.org/article/91bf0e4959f147c7939554fa0cf7814f
Autor:
Inés Paniagua, Zainab Tayeh, Mattia Falcone, Santiago Hernández Pérez, Aurora Cerutti, Jacqueline J. L. Jacobs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
MAD2L2 – as a member of the shieldin complex - counteracts resection during DNA repair. Here the authors demonstrate that MAD2L2 protects stalled replication forks from excessive resection, in a shieldin-independent and REV3L-dependent manner.
Externí odkaz:
https://doaj.org/article/a9b173c02d504a909a58c98740cb0626
Autor:
Martien J. P. van Bussel, Gaby J. Odekerken–Schröder, Carol Ou, Rachelle R. Swart, Maria J. G. Jacobs
Publikováno v:
BMC Health Services Research, Vol 22, Iss 1, Pp 1-23 (2022)
Abstract Background Technological progress in artificial intelligence has led to the increasing popularity of virtual assistants, i.e., embodied or disembodied conversational agents that allow chatting with a technical system in a natural language. H
Externí odkaz:
https://doaj.org/article/b6c96056e1804a8faed0f14e95d5abf4
Publikováno v:
IUCrJ, Vol 9, Iss 2, Pp 180-193 (2022)
Radiopharmaceutical development has similar overall characteristics to any biomedical drug development requiring a compound's stability, aqueous solubility and selectivity to a specific disease site. However, organometallic complexes containing 188/1
Externí odkaz:
https://doaj.org/article/91de7430781f4efa99aea649647f421c