Zobrazeno 1 - 10
of 82
pro vyhledávání: '"J. A. Himes"'
Autor:
Jinshan Shen, Jiayin Huang, Licong Jiang, Sarah Robertson, Linda T Wang, J Lekstrom-Himes, Kristin Stephan, Sagar Agarwal, Varun Garg, Linda Han, Asfiha Gebre, Chonghua Li
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 3, Pp 267-275 (2019)
Clinical and Translational Science
Clinical and Translational Science
Drug-drug interaction (DDI) studies are described for tezacaftor/ivacaftor, a new cystic fibrosis transmembrane conductance regulator modulator therapy for the treatment of cystic fibrosis. Three phase I DDI studies were conducted in healthy subjects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ebbfa4f40060187167bd54b70ba6d74
https://doaj.org/article/aec30125588041488b9afe4db9f884f8
https://doaj.org/article/aec30125588041488b9afe4db9f884f8
Autor:
Yimeng Lu, Markus Y. Mapara, Niraj Shanbhag, Damiano Rondelli, Franco Locatelli, C. Fernández, Sandeep Soni, Donna A. Wall, Yael Bobruff, John K. Wu, Stephan A. Grupp, Sarah D. Mulcahey, Sujit Sheth, Haydar Frangoul, Antonis Kattamis, Maria Domenica Cappellini, Tony W. Ho, J Lekstrom-Himes, Mariane de Montalembert, Martin H. Steinberg, Selim Corbacioglu, Josu de la Fuente, Rupert Handgretinger, Michael J. Weinstein, Suzan Imren
Publikováno v:
Transplantation and Cellular Therapy. 27:S72-S73
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89e261f83fae91cabdc601c32eeadf0e
https://doi.org/10.1016/s2666-6367(21)00101-9
https://doi.org/10.1016/s2666-6367(21)00101-9
Autor:
Antonis Kattamis, Maria Domenica Cappellini, Martin H. Steinberg, Franco Locatelli, Josu de la Fuente, Sandeep Soni, Damiano Rondelli, Suzan Imren, Sujit Sheth, Tony W. Ho, Stephan A. Grupp, Yimeng Lu, Michael J. Weinstein, Donna A. Wall, Markus Y. Mapara, John K. Wu, Yael Bobruff, Haydar Frangoul, Rupert Handgretinger, Selim Corbacioglu, Sarah D. Mulcahey, J Lekstrom-Himes, Mariane de Montalembert, Niraj Shanbhag, C. Fernández
Publikováno v:
Blood. 136:3-4
Background: BCL11A is a key transcription factor that suppresses the production of fetal hemoglobin (HbF) in red blood cells (RBCs), leading to the production of adult Hb (HbA). In diseases with hemoglobin production defects such as b-thalassemia, or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51825e58e3d346f75b0a6ca5dd93bca1
https://doi.org/10.1182/blood-2020-139575
https://doi.org/10.1182/blood-2020-139575
Autor:
JS Elborn, O Sommerburg, X You, Y Yang, R Rendas-Baum, M Kosinski, B Loop, J Lekstrom-Himes, AA Rizio
Publikováno v:
60. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V..
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15df56e028ae97884c59a2c565588bc2
https://doi.org/10.1055/s-0039-1678165
https://doi.org/10.1055/s-0039-1678165
Autor:
R Rendas-Baum, Steven M. Rowe, M Kosinski, C-C Chuang, X You, B Loop, J Lekstrom-Himes, Jane C. Davies, Y Yang, AA Rizio
Publikováno v:
Cystic fibrosis: correctors and potentiators.
Introduction and objectives To examine the treatment effect of TEZ/IVA on disease-related symptoms, functioning, and well-being as measured by Cystic Fibrosis Questionnaire–Revised (CFQ-R) in patients heterozygous for F508del and a second allele wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f55bd5dcb018526d91f5a26403eb7d2c
https://doi.org/10.1136/thorax-2018-212555.73
https://doi.org/10.1136/thorax-2018-212555.73
Publikováno v:
Cystic fibrosis: correctors and potentiators.
Introduction and objectives Tezacaftor/Ivacaftor (TEZ/IVA), a new CFTR modulator combination, improves forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in patients aged ≥12 years with CF homozygous for F508del-CFTR (F/F; EVOLV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acc26b2c13c54455be901a384f9622f8
https://doi.org/10.1136/thorax-2018-212555.75
https://doi.org/10.1136/thorax-2018-212555.75
Autor:
R Rendas-Baum, AA Rizio, J Lekstrom-Himes, B Loop, M Kosinski, JS Elborn, X You, C-C Chuang, A Sole, Jennifer L. Taylor-Cousar, Y Yang
Publikováno v:
Cystic fibrosis: correctors and potentiators.
Introduction and objectives To examine the impact of TEZ/IVA on disease-related symptoms, functioning, and well-being as measured by Cystic Fibrosis Questionnaire–Revised (CFQ-R) in patients with cystic fibrosis (CF) homozygous for F508del-CFTR (F5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89b93d2064bc7f6021aba3f760b10b7b
https://doi.org/10.1136/thorax-2018-212555.74
https://doi.org/10.1136/thorax-2018-212555.74
Autor:
Caroline A. Owen, Daniel Campbell, J. Lekstrom-Himes, A. Brody, Claire E. Wainwright, Linda T Wang, L.T. Wang, J. Goldin, S. Stick, R.S. Harris
Publikováno v:
Journal of Cystic Fibrosis. 18:S11-S12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37129cb568891b4297bb86015066a377
https://doi.org/10.1016/s1569-1993(19)30152-3
https://doi.org/10.1016/s1569-1993(19)30152-3
Publikováno v:
Journal of Cystic Fibrosis. 17:S65-S66
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5d2ec3630be70a76f3b4b690b778efd
https://doi.org/10.1016/s1569-1993(18)30321-7
https://doi.org/10.1016/s1569-1993(18)30321-7
Autor:
Patrick A. Flume, H. Zhou, K. De Boeck, J. Lekstrom-Himes, Christopher Simard, Damian G. Downey, R. Fischer Biner, Caroline A. Owen
Publikováno v:
Journal of Cystic Fibrosis. 17:S64-S65
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37e3fbc417126d611f9a96edd1981977
https://doi.org/10.1016/s1569-1993(18)30318-7
https://doi.org/10.1016/s1569-1993(18)30318-7