Zobrazeno 1 - 10
of 801
pro vyhledávání: '"J. A. Goodwin"'
Autor:
Nikita Sushentsev, Gregory Hamm, Lucy Flint, Daniel Birtles, Aleksandr Zakirov, Jack Richings, Stephanie Ling, Jennifer Y. Tan, Mary A. McLean, Vinay Ayyappan, Ines Horvat Menih, Cara Brodie, Jodi L. Miller, Ian G. Mills, Vincent J. Gnanapragasam, Anne Y. Warren, Simon T. Barry, Richard J. A. Goodwin, Tristan Barrett, Ferdia A. Gallagher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Hyperpolarised magnetic resonance imaging (HP-13C-MRI) has shown promise as a clinical tool for detecting and characterising prostate cancer. Here we use a range of spatially resolved histological techniques to identify the biological mechan
Externí odkaz:
https://doaj.org/article/5d269719830146bfb19310f180c8fbe9
Autor:
Lorna Hopcroft, Eleanor M. Wigmore, Stuart C. Williamson, Susana Ros, Cath Eberlein, Jennifer I. Moss, Jelena Urosevic, Larissa S. Carnevalli, Sara Talbot, Lauren Bradshaw, Catherine Blaker, Sreeharsha Gunda, Venetia Owenson, Scott Hoffmann, Daniel Sutton, Stewart Jones, Richard J. A. Goodwin, Brandon S. Willis, Claire Rooney, Elza C. de Bruin, Simon T. Barry
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Combining the selective AKT inhibitor, capivasertib, and SERD, fulvestrant improved PFS in a Phase III clinical trial (CAPItello-291), treating HR+ breast cancer patients following aromatase inhibitors, with or without CDK4/6 inhibitors. How
Externí odkaz:
https://doaj.org/article/216706db2e6b4b6eae15d98244910c27
Autor:
Sally J. Adua, Anna Arnal-Estapé, Minghui Zhao, Bowen Qi, Zongzhi Z. Liu, Carolyn Kravitz, Heather Hulme, Nicole Strittmatter, Francesc López-Giráldez, Sampada Chande, Alexandra E. Albert, Mary-Ann Melnick, Bomiao Hu, Katerina Politi, Veronica Chiang, Nicola Colclough, Richard J. A. Goodwin, Darren Cross, Paul Smith, Don X. Nguyen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
While EGFR-targeted therapies have clinical benefit, drug-resistant brain metastases present a major obstacle. Here, the authors identify a genetic signature in brain metastatic lesions associated with osimertinib resistance and find RhoA to have an
Externí odkaz:
https://doaj.org/article/3190ed6c2b6648c6bd0e559653995e8f
Autor:
Lorna Hopcroft, Eleanor M. Wigmore, Stuart C. Williamson, Susana Ros, Cath Eberlein, Jennifer I. Moss, Jelena Urosevic, Larissa S. Carnevalli, Sara Talbot, Lauren Bradshaw, Catherine Blaker, Sreeharsha Gunda, Venetia Owenson, Scott Hoffmann, Daniel Sutton, Stewart Jones, Richard J. A. Goodwin, Brandon S. Willis, Claire Rooney, Elza C. de Bruin, Simon T. Barry
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/597341a4bba64230b85546c506522cc0
Autor:
Andreas Dannhorn, Maria Luisa Doria, James McKenzie, Paolo Inglese, John G. Swales, Gregory Hamm, Nicole Strittmatter, Gareth Maglennon, Sadaf Ghaem-Maghami, Richard J. A. Goodwin, Zoltan Takats
Publikováno v:
Metabolites, Vol 13, Iss 3, p 377 (2023)
With increased use of mass spectrometry imaging (MSI) in support of pharmaceutical research and development, there are opportunities to develop analytical pipelines that incorporate exploratory high-performance analysis with higher capacity and faste
Externí odkaz:
https://doaj.org/article/1d5aa5490a814cb2a53671fe7ba7d3e8
Publikováno v:
New Journal of Physics, Vol 25, Iss 1, p 013004 (2023)
The generation of entanglement between distant atoms via single photons is the basis for networked quantum computing, a promising route to large-scale trapped-ion and trapped-atom processors. Locating the emitter within an optical cavity provides an
Externí odkaz:
https://doaj.org/article/b2b0284e745f4d1aab226bfb3883d89f
Autor:
Andreas Dannhorn, John G. Swales, Gregory Hamm, Nicole Strittmatter, Hiromi Kudo, Gareth Maglennon, Richard J. A. Goodwin, Zoltan Takats
Publikováno v:
Pharmaceuticals, Vol 15, Iss 11, p 1307 (2022)
Fixation of samples is broadly used prior to the histological evaluation of tissue samples. Though recent reports demonstrated the ability to use fixed tissues for mass spectrometry imaging (MSI) based proteomics, glycomics and tumor classification s
Externí odkaz:
https://doaj.org/article/3575921847eb43848880aec91ef61da6
Autor:
Andreas Dannhorn, Emine Kazanc, Gregory Hamm, John G. Swales, Nicole Strittmatter, Gareth Maglennon, Richard J. A. Goodwin, Zoltan Takats
Publikováno v:
Metabolites, Vol 12, Iss 3, p 261 (2022)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a standard tool used for absolute quantification of drugs in pharmacokinetic (PK) studies. However, all spatial information is lost during the extraction and elucidation of a drugs biodistr
Externí odkaz:
https://doaj.org/article/ed31ac602e6b46538c0a9a66920551bf
Autor:
Andrea Flores Burroughs, Sylvia Eluhu, Diva Whalen, J. Shawn Goodwin, Amos M. Sakwe, Ifeanyi J. Arinze
Publikováno v:
Cellular Physiology and Biochemistry, Vol 47, Iss 2, Pp 800-816 (2018)
Background/Aims: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a basic leucine-zipper transcription factor essential for cellular responses to oxidative stress. Degradation of Nrf2 in the cytoplasm, mediated by Keap1-Cullin3/RING box1 (Cul3-R
Externí odkaz:
https://doaj.org/article/5bce30adc77a47ee95b54b0c42989ebe
Autor:
Georgia Charkoftaki, Nicholas J. W. Rattray, Per E. Andrén, Richard M. Caprioli, Steve Castellino, Mark W. Duncan, Richard J. A. Goodwin, Kevin L. Schey, Sheerin K. Shahidi-Latham, Kirill A. Veselkov, Caroline H. Johnson, Vasilis Vasiliou
Publikováno v:
Human Genomics, Vol 12, Iss 1, Pp 1-6 (2018)
Externí odkaz:
https://doaj.org/article/7368424fbc7c49c6acebb5cbffb8b825