Výsledky vyhledávání - "J. A. Double"

Transplantable colon tumors as chemotherapy screening models

Autor: J. A. Double, C. R. Ball

Publikováno v: Cancer. 36:2437-2440

A series of transplantable murine colon tumors have been developed from primary tumors induced by dimethylhydrazine. They are moderately- to well-differentiated adenocarcinomas which retain their histologic appearance and growth characteristics throu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf858f08ea109d662ab3afe7ddf1bd94
https://doi.org/10.1002/1097-0142(197512)36:6<2437::aid-cncr2820360626>3.0.co

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A novel strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9

Autor: Roger M. Phillips, Brian Naylor, P. A. Hamilton Stewart, J. A. Double, Tariq Shah, G. M. Flannigan, G. A. Choudry, John E. Brown, M. R. L. Krul

Publikováno v: British Journal of Cancer

The indolequinone EO9 demonstrated good preclinical activity but failed to show clinical efficacy against a range of tumours following intravenous drug administration. A significant factor in EO9's failure in the clinic has been attributed to its rap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55ac0a66429153fba0ded4604468ab9
http://europepmc.org/articles/PMC2375160

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EO9: relationship between DT-diaphorase levels and response in vitro and in vivo

Autor: Mike C. Bibby, J A Double, J Collard, A M Matthew

Publikováno v: British Journal of Cancer

EO9 [3-hydroxy-5-aziridinyl-1-methyl-2(1H-indole-4,7-dione)-prop-beta-en- alpha-ol] was selected for clinical trial in Europe because of its preclinical profile but also because of its distinct mechanism of bioactivation. Several studies have shown t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e130f1f4338cc83232afb74a49a2bc8
https://doi.org/10.1038/bjc.1995.233

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ChemInform Abstract: Synthesis and Antitumor Activity of New Derivatives of Flavone-8- acetic Acid (FAA). Part 1. 6-Methyl Derivatives

Autor: R. A. AITKEN, M. C. BIBBY, J. A. DOUBLE, R. M. PHILLIPS, S. K. SHARMA

Publikováno v: ChemInform. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::450ade7a46393497bd3ef11d591bbd2b
https://doi.org/10.1002/chin.199713105

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ChemInform Abstract: Synthesis and Antitumor Activity of New Derivatives of Flavone-8- acetic Acid (FAA). Part 2. Ring-Substituted Derivatives

Autor: Robert B. Ritchie, R. A. Aitken, M. C. Bibby, Andrea L. Laws, J. A. Double, David W. J. Wilson

Publikováno v: ChemInform. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e84e5a34c0b6c0de7cc34d6d4e60813
https://doi.org/10.1002/chin.199749158

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ChemInform Abstract: Synthesis and Antitumor Activity of New Derivatives of Flavone-8-acetic Acid (FAA). Part 3. 2-Heteroaryl Derivatives

Autor: M. C. Bibby, R. Alan Aitken, Anne‐Laure Mathieu, David W. J. Wilson, Andrea L. Laws, Florian Bielefeldt, Robert B. Ritchie, J. A. Double

Publikováno v: ChemInform. 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73b938f67d70e6090172a59871528cf0
https://doi.org/10.1002/chin.199913164

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Influence of hydralazine on the pharmacokinetics of tauromustine (TCNU) in mice

Autor: Paul M. Loadman, J. A. Double, A. F. al-Ghabban, Mike C. Bibby

Publikováno v: British Journal of Cancer

Several investigators including ourselves have shown that hydralazine can potentiate the anti-tumour activity of certain agents against murine tumours probably by manipulating tumour blood flow. In order to investigate the effects of administration o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e10b07529baaa3773849b40030f58aa
https://doi.org/10.1038/bjc.1992.70

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Towards improved cancer diagnosis and treatment founded on current developments in the basic sciences: Options for intensified european efforts

Autor: Manfred F. Rajewsky, W. H. Gunzburg, Bruce A.J. Ponder, R. Monier, R. Nusse, F. Cavalli, Silvio Garattini, M. S. Aapro, H. H. Hansen, A. Mantovani, C. H. Heldin, J. P. Mach, W. Birchmeier, J. A. Double, R. E. Leake, M. Tubiani, C. Helene, Eckhard Jähde, G. Riethmuller

Publikováno v: European Journal of Cancer and Clinical Oncology. 27:936-939

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02cb5d59c574231bdd7dd63cd2bfbd06
https://doi.org/10.1016/0277-5379(91)90151-3

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The relationship between tissue levels of flavone acetic acid (NSC 347512) and site dependent anti-tumour activity in murine colon tumours

Autor: Roger M. Phillips, Mike C. Bibby, J. A. Double

Publikováno v: British Journal of Cancer

Flavone acetic acid (FAA) is extremely active against subcutaneous transplantable tumours in mice, but disappointingly there has been no demonstrable clinical activity. Previous studies have shown that lung tumour deposits are less responsive than th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be3f2c44a7cc9a0779f59968522c07bf
https://doi.org/10.1038/bjc.1991.127

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Antitumor activity of imidazothioxanthones in murine and human tumor models in vitro and in vivo

Autor: A, Varvaresou, K, Iakovou, E, Gikas, I, Fichtner, H H, Fiebig, L R, Kelland, J A, Double, M C, Bibby, H R, Hendriks

Publikováno v: Anticancer research. 24(2B)

A new series of imidazothioxanthones has recently been synthesized as potential anticancer agents with the aim of overcoming drug resistance. The route of synthesis and DNA-binding properties of the compounds were reported previously. This paper desc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58a5f6d0b710ebdb8966a1267885541b
https://pubmed.ncbi.nlm.nih.gov/15161044

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