Výsledky vyhledávání - "J. A. Di Paolo"

POS0224 SELECTIVITY OF CLINICAL JAK INHIBITORS AND THE IMPACT ON NATURAL KILLER (NK) CELL FUNCTIONAL RESPONSES

Autor: L. Simpson, G. Min-Oo, E. Grant, J. A. Di Paolo, P. Gonzalez-Traves, Bernard P. Murray, Amy Meng

Publikováno v: Annals of the Rheumatic Diseases. 80:331.1-331

Background:Janus kinase (JAK) inhibitors (JAKinibs) show similar efficacy in rheumatoid arthritis (RA). However, in vitro studies have shown differences in JAK selectivity profiles for baricitinib (BARI), tofacitinib (TOFA), upadacitinib (UPA) and fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abea34200585e7a24f14a828cbe93313
https://doi.org/10.1136/annrheumdis-2021-eular.2741

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THU0070 DEFINING SYNOVIAL SIGNATURES IN THE RAT CIA MODEL: WHAT CAN WE LEARN ABOUT RA PROGRESSION?

Autor: J. A. Di Paolo, D. Ruelas, David Lopez, V. Lira, R. Li, G. Min-Oo, L. Li, C. Franci

Publikováno v: Annals of the Rheumatic Diseases. 79:247.2-248

Background:Patients showing inadequate or no response to current therapies represent a key unmet need in rheumatoid arthritis (RA). To address this, novel or combination therapies are of high clinical interest. Identification of novel therapeutic tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e94c34dee79572017fa369deb7c93d78
https://doi.org/10.1136/annrheumdis-2020-eular.3695

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SAT0016 DEVELOPMENT OF FIBROBLAST-LIKE SYNOVIOCYTE ASSAYS FOR TARGET DISCOVERY IN RHEUMATOID ARTHRITIS

Autor: V. Lira, G. Min-Oo, D. Ruelas, Kevin S. Currie, Helen Yu, C. Chen, Y. Moazami, J. A. Di Paolo, H. Truong

Publikováno v: Annals of the Rheumatic Diseases. 79:938.1-938

Background:The rheumatoid arthritis (RA) synovium is characterized by an overabundance of fibroblast-like synoviocytes (FLS), which play a central role in the initiation and perpetuation of disease via multiple mechanisms.1FLS promote disease progres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c5895b38a5abbb0f9af9d56a667908d
https://doi.org/10.1136/annrheumdis-2020-eular.3752

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THU0067 JAK SELECTIVITY AND THE IMPACT ON CYTOKINE SIGNALING INHIBITION AT CLINICAL RHEUMATOID ARTHRITIS DOSES

Autor: Bernard P. Murray, J. A. Di Paolo, P. Gonzalez-Traves, F. Campigotto, Amy Meng

Publikováno v: Annals of the Rheumatic Diseases. 79:246.1-246

Background:Janus kinase 1 (JAK1) inhibitors are efficacious in rheumatoid arthritis (RA). Despite having similar efficacy, in vitro studies have shown differences in JAK selectivity profiles for the small-molecule JAK inhibitors (JAKi) baricitinib (B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f138846fd70d974a8c3e3e45a4c07c8b
https://doi.org/10.1136/annrheumdis-2020-eular.2074

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AB0484 Monotherapy with filgotinib, a jak1-selective inhibitor, reduces disease severity and alters immune cell subsets in the nzb/w f1 murine model of lupus

Autor: C. Pohlmeyer, Z.-H. Cui, J. A. Di Paolo, S. Zaboli, A. Shauf, Nevena Mollova, Randall Mark Jones, Igor Mikaelian, Pei Han, Astrid S. Clarke

Publikováno v: Rheumatoid arthritis – non biologic treatment and small molecules.

Background Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterised by immune system hyperactivation leading to the production of autoantibodies and immune attack on multiple organs including the skin and kidneys. High l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::253eec6a960895ab0b586085829bb095
https://doi.org/10.1136/annrheumdis-2018-eular.3367

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FRI0049 Preclinical Characterization of GS-9876, A Novel, Oral SYK Inhibitor That Shows Efficacy in Multiple Established Rat Models of Collagen-Induced Arthritis

Autor: Sarah Wise, Tony Lee, Kropf Jeffrey E, Jianjun Xu, Peter Blomgren, Scott A. Mitchell, Bernard P. Murray, Kevin S. Currie, J. A. Di Paolo, Michael J. Dolton, Zhongdong Zhao, Randall Mark Jones, K. Suekawa-Pirrone

Publikováno v: Annals of the Rheumatic Diseases. 75:443.3-444

Background Spleen Tyrosine Kinase (SYK) mediates signaling in a range of hematopoietic cells involved in the initiation and progression of RA including B cells, monocytes, macrophages, dendritic cells, and osteoclasts. There is strong preclinical val

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff3bfdbb6d22fd8e060fc8cdeeee9cd7
https://doi.org/10.1136/annrheumdis-2016-eular.2209

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A correlation of clinical observations to in vitro sensitivity test for cancer chemotherapy

Autor: A L, WATNE, J A, DI PAOLO

Publikováno v: Cancer chemotherapy reports. 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b276bd4d1616ae4319cf941557bd29d4
https://pubmed.ncbi.nlm.nih.gov/13999178

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