Zobrazeno 1 - 10
of 48
pro vyhledávání: '"J. A. Coderre"'
Publikováno v:
International journal of radiation biology. 79(3)
Recently, various boronated porphyrins have been shown to preferentially target a variety of tumour types. Of the different porphyrins evaluated, copper tetra-phenyl-carboranyl porphyrin (CuTCPH) is a strong candidate for future preclinical evaluatio
Autor:
H M, Smilowitz, J A, Coderre, M M, Nawrocky, W, Tu, A, Pinkerton, G H, Jahng, N, Gebbers, D N, Slatkin
Publikováno v:
Journal of neuro-oncology. 57(1)
Rats with advanced, imminently lethal, approximately 4 mm diameter, left-sided intracerebral 9L gliosarcoma (9LGS), a well characterized malignant tumor with some similarities to human high-grade astrocytomas, were used as a therapy model 14 days pos
Publikováno v:
Cancer research. 61(22)
Boron neutron capture therapy (BNCT) is dependent on the selective accumulation of boron-10 in tumor cells relative to the contiguous normal cells. Ion microscopy was used to evaluate the microdistribution of boron-10 from p-boronophenylalanine (BPA)
Autor:
M, Miura, D D, Joel, H M, Smilowitz, M M, Nawrocky, P L, Micca, D A, Hoch, J A, Coderre, D N, Slatkin
Publikováno v:
Journal of neuro-oncology. 52(2)
The biodistributions of carborane-containing copper porphyrins, CuTCP and CuTCPH, have been studied previously in mice bearing subcutaneously implanted mammary carcinomas. We now report biodistributions of those porphyrins in Fischer 344 rats bearing
Publikováno v:
Journal of neuro-oncology. 52(2)
New clinical protocols are being developed that will entail the administration of considerably higher doses of the boron delivery agent boronophenylalanine (BPA) than those in current clinical use. Fractionation (2 or 4 fractions) of BPA mediated bor
Autor:
M, Miura, G M, Morris, P L, Micca, D T, Lombardo, K M, Youngs, J A, Kalef-Ezra, D A, Hoch, D N, Slatkin, R, Ma, J A, Coderre
Publikováno v:
Radiation research. 155(4)
The first control of a malignant tumor in vivo by porphyrin- mediated boron neutron capture therapy (BNCT) is described. In mice bearing implanted EMT-6 mammary carcinomas, boron uptake using a single injection of either p-boronophenylalanine (BPA) o
Publikováno v:
Journal of neuro-oncology. 48(1)
Twelve normal dogs underwent brain irradiation in a mixed-radiation, mainly epithermal neutron field at the Brookhaven Medical Research Reactor following intravenous infusion of 950 mg of 10B-enriched BPA/kg as its fructose complex. The 5 x 10 cm irr
Autor:
C S, Landis, X, Li, F W, Telang, J A, Coderre, P L, Micca, W D, Rooney, L L, Latour, G, Vétek, I, Pályka, C S, Springer
Publikováno v:
Magnetic resonance in medicine. 44(4)
For bolus-tracking studies, it is commonly assumed that CR concentration bears a linear relationship with the measured (usually longitudinal) (1)H(2)O relaxation rate constant, R*(1) identical with(T(1) *)(-1). This requires that equilibrium transcyt
Publikováno v:
Journal of neuro-oncology. 46(3)
Glioblastoma multiforme (GBM) is the most common primary human brain tumor. About 7000 new cases are diagnosed yearly in the USA and GBM is almost invariably fatal within a few years after it is diagnosed. Despite current neurosurgical and radiothera
Autor:
H M, Smilowitz, D D, Joel, D N, Slatkin, P L, Micca, M M, Nawrocky, K, Youngs, W, Tu, J A, Coderre
Publikováno v:
Journal of neuro-oncology. 46(3)
Glioblastoma multiforme (GBM) is the most common primary human brain tumor. About 7000 new cases are diagnosed yearly in the USA. Despite current neurosurgical and postoperative radiotherapeutic tumor cytoreduction methods, in most cases occult foci