Zobrazeno 1 - 2
of 2
pro vyhledávání: '"J. A. Chuckowree"'
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Brain penetrant microtubule stabilising agents (MSAs) are being increasingly validated as potential therapeutic strategies for neurodegenerative diseases and traumatic injuries of the nervous system. MSAs are historically used to treat malig
Externí odkaz:
https://doaj.org/article/4bdba742d30049b0b11e7bf02dd84e9c
Autor:
J A, Clark, C A, Blizzard, M C, Breslin, E J, Yeaman, K M, Lee, J A, Chuckowree, T C, Dickson
Publikováno v:
Neuropathology and applied neurobiology. 44(6)
Degeneration of the distal neuromuscular circuitry is a hallmark pathology of Amyotrophic Lateral Sclerosis (ALS). The potential for microtubule dysfunction to be a critical pathophysiological mechanism in the destruction of this circuitry is increas