Zobrazeno 1 - 10
of 167
pro vyhledávání: '"J. A. Alspaugh"'
Autor:
Lukas M. du Plooy, Calla L. Telzrow, Connie B. Nichols, Corinna Probst, Natalia Castro-Lopez, Floyd L. Wormley, J. Andrew Alspaugh
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Cellular responses to external stress allow microorganisms to adapt to a vast array of environmental conditions, including infection sites. The molecular mechanisms behind these responses are studied to gain insight into microbial pathogenes
Externí odkaz:
https://doaj.org/article/6afdb1943cbe404d9dfbeb5018096d34
Autor:
Kaila M. Pianalto, Calla L. Telzrow, Hannah Brown Harding, Jacob T. Brooks, Joshua A. Granek, Eduardo Gushiken-Ibañez, Salomé LeibundGut-Landmann, Joseph Heitman, Giuseppe Ianiri, J. Andrew Alspaugh
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT During mammalian colonization and infection, microorganisms must be able to rapidly sense and adapt to changing environmental conditions including alterations in extracellular pH. The fungus-specific Rim/Pal signaling pathway is one process
Externí odkaz:
https://doaj.org/article/dada565781b7409a9bc8099b6a4d1b79
Autor:
Matthew J O'Meara, Jackson R Rapala, Connie B Nichols, A Christina Alexandre, R Blake Billmyre, Jacob L Steenwyk, J Andrew Alspaugh, Teresa R O'Meara
Publikováno v:
PLoS Genetics, Vol 20, Iss 2, p e1011158 (2024)
Elucidating gene function is a major goal in biology, especially among non-model organisms. However, doing so is complicated by the fact that molecular conservation does not always mirror functional conservation, and that complex relationships among
Externí odkaz:
https://doaj.org/article/65ef4ddc629c437bbbd2a8ec1d36b4e8
Autor:
Corinna Probst, Magnus Hallas-Møller, Johan Ø Ipsen, Jacob T Brooks, Karsten Andersen, Mireille Haon, Jean-Guy Berrin, Helle J Martens, Connie B Nichols, Katja S Johansen, J Andrew Alspaugh
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1010946 (2023)
Fungi often adapt to environmental stress by altering their size, shape, or rate of cell division. These morphological changes require reorganization of the cell wall, a structural feature external to the cell membrane composed of highly interconnect
Externí odkaz:
https://doaj.org/article/5b53086b515f485db0cf1679cf628b5d
Autor:
Calla L. Telzrow, Shannon Esher Righi, Jackson M. Cathey, Joshua A. Granek, J. Andrew Alspaugh
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Microbial pathogens undergo significant physiological changes during interactions with the infected host, including alterations in metabolism and cell architecture. The Cryptococcus neoformans Mar1 protein is required for the proper ord
Externí odkaz:
https://doaj.org/article/bda29b4a63e8443080efdf9034719958
Autor:
Eun Jung Thak, Ye Ji Son, Dong-Jik Lee, Hyunah Kim, Jung Ho Kim, Su-Bin Lee, Yu-Byeong Jang, Yong-Sun Bahn, Connie B. Nichols, J. Andrew Alspaugh, Hyun Ah Kang
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT The human-pathogenic yeast Cryptococcus neoformans assembles two types of O-linked glycans on its proteins. In this study, we identified and functionally characterized the C. neoformans CAP6 gene, encoding an α1,3-mannosyltransferase respon
Externí odkaz:
https://doaj.org/article/5c141b409d904c7580e706402483db9d
Autor:
Piotr R. Stempinski, Kristie D. Goughenour, Lukas M. du Plooy, J. Andrew Alspaugh, Michal A. Olszewski, Lukasz Kozubowski
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Cryptococcus neoformans, an opportunistic yeast pathogen, relies on a complex network of stress response pathways that allow for proliferation in the host. In Saccharomyces cerevisiae, stress responses are regulated by integral membrane prot
Externí odkaz:
https://doaj.org/article/fd20021cafc74f399d55030b8075a0b0
Autor:
Raffael Júnio Araújo de Castro, Marco Túlio Aidar Mariano Rêgo, Fabiana S. Brandão, Ana Laura Alfonso Pérez, Janice Lisboa De Marco, Marcio José Poças-Fonseca, Connie Nichols, J. Andrew Alspaugh, Maria Sueli S. Felipe, Alexandre Alanio, Anamélia Lorenzetti Bocca, Larissa Fernandes
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Cryptococcus neoformans is an opportunistic fungal pathogen known for its remarkable ability to infect and subvert phagocytes. This ability provides survival and persistence within the host and relies on phenotypic plasticity. The viable but
Externí odkaz:
https://doaj.org/article/504b6a0303ed44faaefaa6fd3e93a753
Autor:
Corinna Probst, Sarela Garcia-Santamarina, Jacob T Brooks, Inge Van Der Kloet, Oliver Baars, Martina Ralle, Dennis J Thiele, J Andrew Alspaugh
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010195 (2022)
Copper homeostasis mechanisms are essential for microbial adaption to changing copper levels within the host during infection. In the opportunistic fungal pathogen Cryptococcus neoformans (Cn), the Cn Cbi1/Bim1 protein is a newly identified copper bi
Externí odkaz:
https://doaj.org/article/8aa673c0ea3e4b4ba86626efcff9d0ae
Autor:
Calla L Telzrow, Paul J Zwack, Shannon Esher Righi, Fred S Dietrich, Cliburn Chan, Kouros Owzar, J Andrew Alspaugh, Joshua A Granek
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 11 (2021)
AbstractRNA sequencing (RNA-Seq) experiments focused on gene expression involve removal of ribosomal RNA (rRNA) because it is the major RNA constituent of cells. This process, called RNA enrichment, is done primarily to reduce cost: without rRNA remo
Externí odkaz:
https://doaj.org/article/1f1e7f4c0f8d42818c119b3b8b401db4