Zobrazeno 1 - 10
of 28
pro vyhledávání: '"J. A. Airey"'
Autor:
J. L. Airey, J. Ogden
Publikováno v:
The Year's Work in English Studies. 93:521-534
Publikováno v:
Journal of Biological Chemistry. 268:22642-22649
Site-specific antibodies against different regions of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum (ryanodine receptor) were developed and used as probes for immunoblotting of the major tryptic fragments resulting from partial d
Autor:
R D, Youssefyeh, H F, Campbell, S, Klein, J E, Airey, P, Darkes, M, Powers, M, Schnapper, K, Neuenschwander, L R, Fitzpatrick, C E, Pendley
Publikováno v:
Journal of Medicinal Chemistry. 35:895-903
This report describes the development of novel benzamides which are orally active, highly potent, specific antagonists of 5-HT3 receptors. Described in this first report are the structure-activity relationships that led to novel structures with impro
Publikováno v:
Pharmacological reviews. 49(1)
The goal of this review has been to describe the current state of the pharmacology of ryanodine and related compounds relative to the vertebrate RyRs. Resolution of questions concerning the molecular properties of RyR channel function and the contrib
Autor:
J. L. Sutko, J. A. Airey
Publikováno v:
Physiological reviews. 76(4)
Complexities in calcium signaling in eukaryotic cells require diversity in the proteins involved in generating these signals. In this review, we consider the ryanodine receptor (RyR) family of intracellular calcium release channels. This includes spe
Publikováno v:
The Journal of biological chemistry. 270(9)
Two ryanodine receptor (RyR), sarcoplasmic reticulum Ca2+ release channels, alpha and beta, co-exist in chicken skeletal muscles. To investigate a two-RyR Ca2+ release system, we compared electrically evoked Ca2+ transients in Crooked Neck Dwarf (cn/
Publikováno v:
The Journal of biological chemistry. 268(30)
Site-specific antibodies against different regions of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum (ryanodine receptor) were developed and used as probes for immunoblotting of the major tryptic fragments resulting from partial d
Autor:
M. Powers, H. F. Campbell, J. E. Airey, W. L. Studt, Herman L. Ammon, F. A. Golec, R. D. Youssefyeh
Publikováno v:
Acta crystallographica. Section C, Crystal structure communications. 49
The absolute configuration was established as (S,S,S) by the R-factor test and by careful measurement of 197 enantiomorph-sensitive Friedel pairs of reflections. The determination also confirms the absolute stereochemistry of (-)-3-aminoquinuclidine,
Publikováno v:
Biochemistry. 32(14)
A full-length cDNA encoding the ryanodine receptor of rabbit skeletal muscle sarcoplasmic reticulum was transiently expressed in COS-1 cells. Immunoblotting studies showed that the expressed ryanodine receptor and the native ryanodine receptor of rab
Autor:
Scott I. Klein, H. F. Campbell, Woodward R, M. Powers, Rodriguez W, J. E. Airey, Golec S, M. Schnapper, Raymond D. Youssefyeh, W. L. Studt
Publikováno v:
Journal of medicinal chemistry. 35(5)
Two new classes of potent 5-HT3 agents have been developed and examined as inhibitors of cytotoxic drug induced emesis in the ferret and dog. The absolute configuration of the most active molecules 10 and 18 have been determined by X-ray crystallogra