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Akademický článek

Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

The prefrontal cortex is involved in goal-directed behaviour. Here the authors show that medial prefrontal cortex activates goal-directed motivation and dopamine neurons via a feedback loop with the anteromedial thalamus.

Externí odkaz: https://doaj.org/article/f95a28191a6f4226870f7f72902acb46

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Akademický článek

Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction in mice

Autor: Andrew J. Kesner, Rick Shin, Coleman B. Calva, Reuben F. Don, Sue Junn, Christian T. Potter, Leslie A. Ramsey, Ahmed F. Abou-Elnaga, Christopher G. Cover, Dong V. Wang, Hanbing Lu, Yihong Yang, Satoshi Ikemoto

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

The supramammillary region (SuM) regulates arousal that reinforces and energizes behavioral interaction with the environment. Here the authors investigate how SuM neurons interact with medial septal neurons and ventral tegmental dopamine neurons to r

Externí odkaz: https://doaj.org/article/1202efdd1112431e947d39aad9ceff5c

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Akademický článek

Whole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in mice

Autor: Christopher G. Cover, Andrew J. Kesner, Shehzad Ukani, Elliot A. Stein, Satoshi Ikemoto, Yihong Yang, Hanbing Lu

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-8 (2021)

Cover et al. develop a method that permits functional MRI of brain dynamics while mice are cued to perform an operant task: licking a spout to receive optogenetic stimulation to the medial prefrontal cortex. This method presents noninvasive whole bra

Externí odkaz: https://doaj.org/article/4105e70bb73b4be9906aa9473aea83ec

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Akademický článek

Cannabinoids, Endocannabinoids and Sleep

Autor: Andrew J. Kesner, David M. Lovinger

Publikováno v: Frontiers in Molecular Neuroscience, Vol 13 (2020)

Sleep is a vital function of the nervous system that contributes to brain and bodily homeostasis, energy levels, cognitive ability, and other key functions of a variety of organisms. Dysfunctional sleep induces neural problems and is a key part of al

Externí odkaz: https://doaj.org/article/65e96249292048998833d08ef5afcaa2

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Akademický článek

Disrupting Glutamate Co-transmission Does Not Affect Acquisition of Conditioned Behavior Reinforced by Dopamine Neuron Activation

Autor: Dong V. Wang, Thomas Viereckel, Vivien Zell, Åsa Konradsson-Geuken, Carl J. Broker, Aleksandr Talishinsky, Ji Hoon Yoo, Melissa H. Galinato, Emma Arvidsson, Andrew J. Kesner, Thomas S. Hnasko, Åsa Wallén-Mackenzie, Satoshi Ikemoto

Publikováno v: Cell Reports, Vol 18, Iss 11, Pp 2584-2591 (2017)

Dopamine neurons in the ventral tegmental area (VTA) were previously found to express vesicular glutamate transporter 2 (VGLUT2) and to co-transmit glutamate in the ventral striatum (VStr). This capacity may play an important role in reinforcement le

Externí odkaz: https://doaj.org/article/bfe981a7bf7e43ac97994bc255db1cc1

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Changes in striatal dopamine release, sleep, and behavior during spontaneous Δ-9-tetrahydrocannabinol abstinence in male and female mice

Autor: Andrew J. Kesner, Yolanda Mateo, Karina P. Abrahao, Stephanie Ramos-Maciel, Matthew J. Pava, Alexa L. Gracias, Riley T. Paulsen, Hartley B. Carlson, David M. Lovinger

Publikováno v: Neuropsychopharmacology. 47:1537-1549

Withdrawal symptoms are observed upon cessation of cannabis use in humans. Although animal studies have examined withdrawal symptoms following exposure to delta-9-tetrahydrocannabinol (THC), difficulties in obtaining objective measures of spontaneous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fd1fc1761c36912933113c40b8b9c59
https://doi.org/10.1038/s41386-022-01326-0

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Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings

Autor: David M. Lovinger, Andrew J. Kesner

Publikováno v: Journal of Neurochemistry. 157:1674-1696

Cannabis sativa is the most widely used illicit drug in the world. Its main psychoactive component is delta-9-tetrahydrocannabinol (THC), one of over 100 phytocannabinoid compounds produced by the cannabis plant. THC is the primary compound that driv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf23cde457588ad529cc6bef45cd9d2
https://doi.org/10.1111/jnc.15369

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Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction in mice

Autor: Ahmed F. Abou-Elnaga, Leslie A. Ramsey, Yihong Yang, Dong V. Wang, Christopher G. Cover, Rick Shin, Satoshi Ikemoto, Christian T. Potter, Sue Junn, Andrew J. Kesner, Coleman B. Calva, Reuben F. Don, Hanbing Lu

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications

The supramammillary region (SuM) is a posterior hypothalamic structure, known to regulate hippocampal theta oscillations and arousal. However, recent studies reported that the stimulation of SuM neurons with neuroactive chemicals, including substance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50411f5a67771e91c135e636b4aae9ed
https://doaj.org/article/1202efdd1112431e947d39aad9ceff5c

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