Zobrazeno 1 - 10
of 87
pro vyhledávání: '"J. K. Nicholson"'
Autor:
J R, Swann, I, Garcia-Perez, V, Braniste, I D, Wilson, J E, Sidaway, J K, Nicholson, S, Pettersson, E, Holmes
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 143
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfefda1b6f7a47b4fd646a58d9fa9a8c
https://pubmed.ncbi.nlm.nih.gov/28595107
https://pubmed.ncbi.nlm.nih.gov/28595107
Publikováno v:
Xenobiotica. 33:855-869
1. The metabolic fate of 4-bromoaniline (4-BrA) was investigated in rat following intraperitoneal administration at 50 mg kg(-1) using HPLC-TOF-MS/MS. 2. The sensitivity provided by the use of TOF-MS/MS, aided by the distinctive isotope pattern resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47667f6d106d0e69068c10f3218dd3c
https://doi.org/10.1080/0049825031000121590
https://doi.org/10.1080/0049825031000121590
Publikováno v:
Xenobiotica. 32:605-613
1. The metabolism and excretion of 2,4-, 3,5-ditrifluoromethyl- and pentafluorobenzoic acids were studied in the bile-cannulated rat using (1)H- and (19)F-NMR spectroscopy following intraperitoneal administration at 50 mg kg(-1). 2. Pentafluorobenzoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ee6032a10a3831ef4d2c173be42c85
https://doi.org/10.1080/00498250210131590
https://doi.org/10.1080/00498250210131590
Publikováno v:
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 5(6)
Ifosfamide (55 mg kg(-1) and 110 mg kg(-1)) was administered via single i.p. injections to Sprague-Dawley rats and urine samples were collected for the periods of -24-0, 0-8 h, 8-24 h, 24-48 h and 48-72 h post-dose. Quantitative changes in the excret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5bde5fb6ec43167222c0f399bdc35a
https://pubmed.ncbi.nlm.nih.gov/23898813
https://pubmed.ncbi.nlm.nih.gov/23898813
Publikováno v:
Journal of biomolecular NMR. 13(1)
In aqueous solution, exchanging peptide NH protons experience two environments, that of the peptide itself with a relatively slow diffusion coefficient and that of the water solvent with a faster diffusion coefficient. Although in slow exchange on th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e113bb94794086e457c1e5e4cd5649d
https://pubmed.ncbi.nlm.nih.gov/21080260
https://pubmed.ncbi.nlm.nih.gov/21080260
Autor:
Elaine Holmes, Cristina Legido-Quigley, Santiago Angulo, Coral Barbas, J. V. Li, Jürg Utzinger, A. Couto Alves, Timothy M. D. Ebbels, J. K. Nicholson, Isabel Garcia-Perez
Publikováno v:
Analytical chemistry. 82(1)
We demonstrate the statistical integration of nuclear magnetic resonance (NMR) spectroscopy and capillary electrophoresis (CE) data in order to describe a pathological state caused by Schistosoma mansoni infection in a mouse model based on urinary me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5126a13fe0078db2c93c575f5cea1a4
https://pubmed.ncbi.nlm.nih.gov/19961175
https://pubmed.ncbi.nlm.nih.gov/19961175
Autor:
E, Holmes, J K, Nicholson
Publikováno v:
Ernst Schering Foundation symposium proceedings. (4)
Metabolic phenotyping in large-scale population studies can yield crucial information regarding the impact and interaction of genetic and environmental factors with regard to the prevalence and risk of chronic diseases. Spectroscopic technologies suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8aa5d4b2ba0fe79399b46ada45965e43
https://pubmed.ncbi.nlm.nih.gov/18811060
https://pubmed.ncbi.nlm.nih.gov/18811060
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 34(1)
1. The products arising from intramolecular acyl migration reactions of drug ester glucuronides are reactive towards cellular proteins and can potentially cause toxic side-effects. The relationship between molecular structure and the degradation rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10f006119f1ad8a83c4ea0775bda8139
https://pubmed.ncbi.nlm.nih.gov/15729774
https://pubmed.ncbi.nlm.nih.gov/15729774
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 32(1)
Following the administration of 2-, 3- and 4-fluorobenzyl alcohols, the major metabolites detected in urine corresponded to the glycine conjugates of the corresponding benzoic acids. Little, or no, unchanged parent compound was detected in the sample
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85e8c8cab3d4518f85c808bd615a242f
https://pubmed.ncbi.nlm.nih.gov/12852455
https://pubmed.ncbi.nlm.nih.gov/12852455
Publikováno v:
Neurochemistry international. 42(1)
The labelling of metabolites with the NMR active nucleus 13C allows not only metabolite enrichments to be monitored, but also the relative fluxes through competing pathways to be delineated. [2-13C, 15N]alanine was used as a metabolic probe to invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b1884b3355d9c2d15b8fa9695fa4b8c
https://pubmed.ncbi.nlm.nih.gov/12441173
https://pubmed.ncbi.nlm.nih.gov/12441173