Zobrazeno 1 - 10
of 2 062
pro vyhledávání: '"J. Ishii"'
Autor:
Izumi Sasaki, Yuri Fukuda-Ohta, Chihiro Nakai, Naoko Wakaki-Nishiyama, Chizuyo Okamoto, Daisuke Okuzaki, Shuhei Morita, Shiori Kaji, Yuki Furuta, Hiroaki Hemmi, Takashi Kato, Asumi Yamamoto, Emi Tosuji, Shin-Ichiroh Saitoh, Takashi Tanaka, Katsuaki Hoshino, Shinji Fukuda, Kensuke Miyake, Etsushi Kuroda, Ken J. Ishii, Takao Iwawaki, Koichi Furukawa, Tsuneyasu Kaisho
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113981- (2024)
Summary: Cholera toxin (CT), a bacterial exotoxin composed of one A subunit (CTA) and five B subunits (CTB), functions as an immune adjuvant. CTB can induce production of interleukin-1β (IL-1β), a proinflammatory cytokine, in synergy with a lipopol
Externí odkaz:
https://doaj.org/article/f22ab996a6a3412b82cc9ee0414c17dd
Autor:
Chieko Yokota, Kosuke Fujimoto, Natsuko Yamakawa, Masamitsu Kono, Daichi Miyaoka, Masaki Shimohigoshi, Miho Uematsu, Miki Watanabe, Yukari Kamei, Akira Sugimoto, Natsuko Kawasaki, Takato Yabuno, Tomotaka Okamura, Eisuke Kuroda, Shigeto Hamaguchi, Shintaro Sato, Muneki Hotomi, Yukihiro Akeda, Ken J. Ishii, Yasuhiro Yasutomi, Kishiko Sunami, Satoshi Uematsu
Publikováno v:
Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-12 (2023)
Abstract Background Although vaccination is recommended for protection against invasive pneumococcal disease, the frequency of pneumococcal pneumonia is still high worldwide. In fact, no vaccines are effective for all pneumococcal serotypes. Fusion p
Externí odkaz:
https://doaj.org/article/707122d771834299ab42a5fa158c5832
Autor:
Burcu Temizoz, Takayuki Shibahara, Kou Hioki, Tomoya Hayashi, Kouji Kobiyama, Michelle Sue Jann Lee, Naz Surucu, Erdal Sag, Atsushi Kumanogoh, Masahiro Yamamoto, Mayda Gursel, Seza Ozen, Etsushi Kuroda, Cevayir Coban, Ken J. Ishii
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a mouse-selective stimulator of interferon gene (STING) agonist exerting STING-dependent anti-tumor activity. Although DMXAA cannot fully activate human STING, DMXAA reached phase III in lung cancer cli
Externí odkaz:
https://doaj.org/article/96d6c342ff5a4b34983c9c8d51741ae6
Autor:
Alphonse Ouédraogo, Edith Christiane Bougouma, Nirianne Marie Q. Palacpac, Sophie Houard, Issa Nebie, Jean Sawadogo, Gloria D. Berges, Issiaka Soulama, Amidou Diarra, Denise Hien, Amidou Z. Ouedraogo, Amadou T. Konaté, Seni Kouanda, Akira Myoui, Sachiko Ezoe, Ken J. Ishii, Takanobu Sato, Flavia D’Alessio, Odile Leroy, Alfred B. Tiono, Simon Cousens, Toshihiro Horii, Sodiomon B. Sirima
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundBK-SE36/CpG is a recombinant blood-stage malaria vaccine candidate based on the N-terminal Plasmodium falciparum serine repeat antigen5 (SE36), adsorbed to aluminium hydroxide gel and reconstituted, prior to administration, with synthetic o
Externí odkaz:
https://doaj.org/article/e22bb3de30e5466fbb0802c8e128c365
Autor:
Lan Yao, Hiam Chemaitelly, Emanuel Goldman, Esayas Kebede Gudina, Asma Khalil, Rahaman Ahmed, Ayorinde Babatunde James, Anna Roca, Mosoka Papa Fallah, Andrew Macnab, William C. Cho, John Eikelboom, Farah Naz Qamar, Peter Kremsner, Miquel Oliu-Barton, Ivan Sisa, Birkneh Tilahun Tadesse, Florian Marks, Lishi Wang, Jerome H. Kim, Xia Meng, Yongjun Wang, Alyce D. Fly, Cong-Yi Wang, Sara W. Day, Scott C. Howard, J. Carolyn Graff, Marcello Maida, Kunal Ray, Carlos Franco-Paredes, Tapfumanei Mashe, Ngashi Ngongo, Jean Kaseya, Nicaise Ndembi, Yu Hu, Maria Elena Bottazzi, Peter J. Hotez, Ken J. Ishii, Gang Wang, Dianjun Sun, Lotfi Aleya, Weikuan Gu
Publikováno v:
EClinicalMedicine, Vol 64, Iss , Pp 102222- (2023)
Summary: In counteracting highly infectious and disruptive respiratory diseases such as COVID-19, vaccination remains the primary and safest way to prevent disease, reduce the severity of illness, and save lives. Unfortunately, vaccination is often n
Externí odkaz:
https://doaj.org/article/abae73e6eb0d4edda474a72fd201eb41
Autor:
Ryota Otsubo, Takeharu Minamitani, Kouji Kobiyama, Junso Fujita, Toshihiro Ito, Shiori Ueno, Itsuki Anzai, Hiroki Tanino, Hiroshi Aoyama, Yoshiharu Matsuura, Keiichi Namba, Ken-Ichi Imadome, Ken J. Ishii, Kouhei Tsumoto, Wataru Kamitani, Teruhito Yasui
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Variants of concern (VOCs) such as Delta and Omicron have developed, which continue to spread the pandemic. It has been reported that th
Externí odkaz:
https://doaj.org/article/f0ba28dc77ab4de48af79db5c1289128
Autor:
Manami Toriyama, Defri Rizaldy, Motoki Nakamura, Yukiko Atsumi, Michinori Toriyama, Fumitaka Fujita, Fumihiro Okada, Akimichi Morita, Hiroshi Itoh, Ken J. Ishii
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/ab4cfdecd5b2421a85d2f9a63f458ab4
Autor:
Ayaka Washizaki, Asako Murayama, Megumi Murata, Tomoko Kiyohara, Keigo Yato, Norie Yamada, Hussein Hassan Aly, Tomohisa Tanaka, Kohji Moriishi, Hironori Nishitsuji, Kunitada Shimotohno, Yasumasa Goh, Ken J. Ishii, Hiroshi Yotsuyanagi, Masamichi Muramatsu, Koji Ishii, Yoshimasa Takahashi, Ryosuke Suzuki, Hirofumi Akari, Takanobu Kato
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The hepatitis B vaccine is recognised as the most effective approach in reducing hepatitis-B-related morbidity; vaccine-escape mutations are however capable of infecting vaccinated individuals. In this work, authors aim to establish a hepatitis B vac
Externí odkaz:
https://doaj.org/article/eab3ce3f48a74871a664e7bab6a1dc86
Autor:
Tomoyuki Otsuka, Sumiyuki Nishida, Takayuki Shibahara, Burcu Temizoz, Masanari Hamaguchi, Takayuki Shiroyama, Keiko Kimura, Kotaro Miyake, Haruhiko Hirata, Yumiko Mizuno, Mayu Yagita, Yusuke Manabe, Etsushi Kuroda, Yoshito Takeda, Hiroshi Kida, Ken J. Ishii, Atsushi Kumanogoh
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract Background Cytosine-phosphate-guanine oligodeoxynucleotide (CpG ODN) (K3)—a novel synthetic single-stranded DNA immune adjuvant for cancer immunotherapy—induces a potential Th1-type immune response against cancer cells. We conducted a ph
Externí odkaz:
https://doaj.org/article/8812c8d7ce2f4eff8b8439c505989aa3
Autor:
Manami Toriyama, Defri Rizaldy, Motoki Nakamura, Yukiko Atsumi, Michinori Toriyama, Fumitaka Fujita, Fumihiro Okada, Akimichi Morita, Hiroshi Itoh, Ken J. Ishii
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: Atopic dermatitis (AD) is a common allergic eczema that affects up to 10% of adults in developed countries. Immune cells in the epidermis, namely, Langerhans cells (LCs), contribute to the pathogenesis of AD, although their exact role(s
Externí odkaz:
https://doaj.org/article/9b3c60e7a91245bf9009ddc6e53ffe4b