Zobrazeno 1 - 10
of 76
pro vyhledávání: '"J. Girgis"'
Autor:
A.P.D. Ramirez, E.E. Peters, J.R. Vanhoy, S.F. Hicks, L.A. Alasagas, D.K. Alcorn-Dominguez, S.T. Block, S.T. Byrd, E.A. Chouinard, B.M. Combs, B.P. Crider, E.C. Derdyn, L. Downes, J.A. Erlanson, S.E. Evans, A.J. French, E.A. Garza, J. Girgis, T.D. Harrison, S.L. Henderson, T.J. Howard, D.T. Jackson, L.J. Kersting, A. Kumar, S.H. Liu, C.J. Lueck, E.M. Lyons, P.J. McDonough, M.T. McEllistrem, T.J. Morin, S. Mukhopadhyay, T.A. Nguyen, M. Nickel, S. Nigam, R.L. Pecha, J. Potter, F.M. Prados-Estévez, B.G. Rice, T.J. Ross, Z.C. Santonil, J. Schneiderjan, L.C. Sidwell, A.J. Sigillito, J.L. Steves, B.K. Thompson, D.W. Watts, Y. Xiao, S.W. Yates
Publikováno v:
Nuclear Physics A. 1023:122446
Akademický článek
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Publikováno v:
The Mental Health Clinician
Introduction: Many psychotropic medications carry a risk of prolonging the QT interval and increasing the risk of developing Torsade de pointes (TdP). The goal of this study was to evaluate whether patients taking psychotropic agents with a known ris
Autor:
J. Girgis
Publikováno v:
Proc. Indon Petrol. Assoc., 24th Ann. Conv..
Publikováno v:
Organic Process Research & Development. 19:290-295
An efficient process was developed for the manufacture of MSA100, a serotonin receptor antagonist, via a five-step synthetic route furnishing a high quality of active pharmaceutical ingredient. Highlights of this synthesis include: (1) replacing carc
Akademický článek
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Autor:
Kevin Vargas, Michael J. Girgis, Wen-Chung Shieh, Yansong Lu, Mahavir Prashad, Zhengming Du, Lech Ciszewski, Edwin Bernard Villhauer, Melissa Lin
Publikováno v:
Tetrahedron. 65:9067-9074
A scalable synthetic strategy of a chiral, trisubstituted imidazolidinone (1), a novel cannabinoid-1 antagonist, starting from a commercially available mandelic acid (5) is described. The key step involves a regio- and stereoselective ring-opening of
Publikováno v:
Organic Process Research & Development. 13:1094-1099
The highly exothermic nature of Reformatsky reagent formation and the reported unpredictability of the induction time for its formation pose challenging problems for scaling up Reformatsky reactions. A zinc-activation procedure using DIBAL-H was deve
Publikováno v:
Journal of Chromatography A. 1216:3927-3932
A modified method for weighing HPLC columns filled with solvent is described. The method prevents the loss of traces of solvent from within the threads of the column. The method was tested by obtaining the weights of a C18 column filled with 10 diffe
Autor:
Caitlin A. Boyd, Pamela L. Kubinski, Xiaoxuan Shen, Laura E. Kuczynski, Michael J. Girgis, Donald Drinkwater, Stanislaw Babiak, Sonia M. Berberena, Megerle L. Scherholz, Brian G. Lefebvre
Publikováno v:
Organic Process Research & Development. 12:1209-1217
The increasing use of metal-containing catalysts in producing pharmaceutical intermediates and active pharmaceutical ingredients, in conjunction with requirements of low metal content in a drug substance, has motivated the development of efficient se