Zobrazeno 1 - 10
of 1 462
pro vyhledávání: '"J. Draper"'
Autor:
Laty G. Thiam, Kirsty McHugh, Aboubacar Ba, Rebecca Li, Yicheng Guo, Mariama N. Pouye, Awa Cisse, Dimitra Pipini, Fatoumata Diallo, Seynabou D. Sene, Saurabh D. Patel, Alassane Thiam, Bacary D. Sadio, Alassane Mbengue, Inés Vigan-Womas, Zizhang Sheng, Lawrence Shapiro, Simon J. Draper, Amy K. Bei
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract Vaccines to the Plasmodium falciparum reticulocyte binding-like protein homologue 5 (PfRH5) target the blood-stage of the parasite life cycle. PfRH5 has the potential to trigger the production of strain-transcendent antibodies and has proven
Externí odkaz:
https://doaj.org/article/e107ccb140a3481e807421a3633b07ca
Autor:
Thomas E Harrison, Nawsad Alam, Brendan Farrell, Doris Quinkert, Amelia M Lias, Lloyd D W King, Lea K Barfod, Simon J Draper, Ivan Campeotto, Matthew K Higgins
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2539-2559 (2024)
Abstract There is an urgent need for improved malaria vaccine immunogens. Invasion of erythrocytes by Plasmodium falciparum is essential for its life cycle, preceding symptoms of disease and parasite transmission. Antibodies which target PfRH5 are hi
Externí odkaz:
https://doaj.org/article/b942500814154714b2e7a3f058d0d828
Autor:
Barnabas G. Williams, Lloyd D. W. King, David Pulido, Doris Quinkert, Amelia M. Lias, Sarah E. Silk, Robert J. Ragotte, Hannah Davies, Jordan R. Barrett, Kirsty McHugh, Cassandra A. Rigby, Daniel G. W. Alanine, Lea Barfod, Michael W. Shea, Li An Cowley, Rebecca A. Dabbs, David J. Pattinson, Alexander D. Douglas, Oliver R. Lyth, Joseph J. Illingworth, Jing Jin, Cecilia Carnrot, Vinayaka Kotraiah, Jayne M. Christen, Amy R. Noe, Randall S. MacGill, C. Richter King, Ashley J. Birkett, Lorraine A. Soisson, Katherine Skinner, Kazutoyo Miura, Carole A. Long, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Reticulocyte-binding protein homologue 5 (RH5), a leading blood-stage Plasmodium falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) and RH5-interacting protein (RIPR) to form an essential heterotrimeri
Externí odkaz:
https://doaj.org/article/c0357f954cd04ff984155d03439a386e
Autor:
Rebecca J. Edge, Amy E. Marriott, Emma L. Stars, Rohit N. Patel, Mark C. Wilkinson, Lloyd D.W. King, Julien Slagboom, Choo Hock Tan, Kavi Ratanabanangkoon, Simon J. Draper, Stuart Ainsworth
Publikováno v:
Toxicon: X, Vol 23, Iss , Pp 100204- (2024)
Snakebite is a major global health concern, for which antivenom remains the only approved treatment to neutralise the harmful effects of the toxins. However, some medically important toxins are poorly immunogenic, resulting in reduced efficacy of the
Externí odkaz:
https://doaj.org/article/7786c6bea5b54487a9ec625049f911c8
Autor:
Emma J. Draper, Ariadne A. Meiboom, Nynke van Dijk, Johannes C. F. Ket, Rashmi A. Kusurkar, Martin Smalbrugge
Publikováno v:
BMC Medical Education, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Although the number of older patients requiring medical care is increasing, caring for older patients is often seen as unattractive by medical trainees (i.e., medical students, residents, interns, and fellows). Terror Management T
Externí odkaz:
https://doaj.org/article/4fb59c383fb448028824bffa822b3113
Autor:
Francisco J. Martinez, Michael White, Micheline Guillotte-Blisnick, Christèle Huon, Alix Boucharlat, Fabrice Agou, Patrick England, Jean Popovici, Mimi M. Hou, Sarah E. Silk, Jordan R. Barrett, Carolyn M. Nielsen, Jenny M. Reimer, Paushali Mukherjee, Virander S. Chauhan, Angela M. Minassian, Simon J. Draper, Chetan E. Chitnis
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract The receptor-binding domain, region II, of the Plasmodium vivax Duffy binding protein (PvDBPII) binds the Duffy antigen on the reticulocyte surface to mediate invasion. A heterologous vaccine challenge trial recently showed that a delayed do
Externí odkaz:
https://doaj.org/article/4ef9c0cbceda4b979429052cf23a7f55
Autor:
Quentin D. Watson, Lenore L. Carias, Alyssa Malachin, Karli R. Redinger, Jürgen Bosch, Martino Bardelli, Lea Baldor, Lionel Brice Feufack-Donfack, Jean Popovici, Robert W. Moon, Simon J. Draper, Peter A. Zimmerman, Christopher L. King
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-14 (2023)
Abstract Background Plasmodium vivax has been more resistant to various control measures than Plasmodium falciparum malaria because of its greater transmissibility and ability to produce latent parasite forms. Therefore, developing P. vivax vaccines
Externí odkaz:
https://doaj.org/article/42de83427cc04061bdc5d1d582ab0c4f
Autor:
Elena Mitsi, Mariana O. Diniz, Jesús Reiné, Andrea M. Collins, Ryan E. Robinson, Angela Hyder-Wright, Madlen Farrar, Konstantinos Liatsikos, Josh Hamilton, Onyia Onyema, Britta C. Urban, Carla Solórzano, Sandra Belij-Rammerstorfer, Emma Sheehan, Teresa Lambe, Simon J. Draper, Daniela Weiskopf, Alessandro Sette, Mala K. Maini, Daniela M. Ferreira
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Respiratory mucosal immunity induced by vaccination is vital for protection from coronavirus infection in animal models. In humans, the capacity of peripheral vaccination to generate sustained immunity in the lung mucosa, and how this is inf
Externí odkaz:
https://doaj.org/article/6d44bf59f3084d30b1170569d157d5ea
Autor:
Jordan R. Barrett, Sarah E. Silk, Catherine G. Mkindi, Karolina M. Kwiatkowska, Mimi M. Hou, Amelia M. Lias, Wilmina F. Kalinga, Ivanny M. Mtaka, Kirsty McHugh, Martino Bardelli, Hannah Davies, Lloyd D. W. King, Nick J. Edwards, Virander S. Chauhan, Paushali Mukherjee, Stella Rwezaula, Chetan E. Chitnis, Ally I. Olotu, Angela M. Minassian, Simon J. Draper, Carolyn M. Nielsen
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
We have previously reported primary endpoints of a clinical trial testing two vaccine platforms for the delivery of Plasmodium vivax malaria DBPRII: viral vectors (ChAd63, MVA), and protein/adjuvant (PvDBPII with 50µg Matrix-M™ adjuvant). Delayed
Externí odkaz:
https://doaj.org/article/1d778520743644f7bdf485e7bb8929be
Autor:
Kazutoyo Miura, Ababacar Diouf, Michael P. Fay, Jordan R. Barrett, Ruth O. Payne, Ally I. Olotu, Angela M. Minassian, Sarah E. Silk, Simon J. Draper, Carole A. Long
Publikováno v:
Malaria Journal, Vol 22, Iss 1, Pp 1-14 (2023)
Abstract Background For blood-stage malaria vaccine development, the in vitro growth inhibition assay (GIA) has been widely used to evaluate functionality of vaccine-induced antibodies (Ab), and Plasmodium falciparum reticulocyte-binding protein homo
Externí odkaz:
https://doaj.org/article/97da816f826f4510910320fa9d5e35e6