Zobrazeno 1 - 10 of 73 pro vyhledávání: '"J.‐P. Thenot"'
1
Akademický článek
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2
Pharmacokinetic analysis of mizolastine in healthy young volunteers after single oral and intravenous doses: noncompartmental approach and compartmental modeling
Autor: F, Mesnil, C, Dubruc, F, Mentre, S, Huet, A, Mallet, J P, Thenot
Publikováno v: Journal of pharmacokinetics and biopharmaceutics. 25(2)
This paper presents the analysis of the kinetics of a new antihistamine, mizolastine, in 18 healthy volunteers, from concentrations measured after an intravenous infusion and two different oral administrations: tablet and capsule. Two approaches were
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca0c72a7b0850ed535eeca6aef06d3ae
https://pubmed.ncbi.nlm.nih.gov/9408856
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3
The disposition and pharmacokinetics of alpidem, a new anxiolytic, in the rat
Autor: D, Garrigou-Gadenne, A, Durand, J P, Thenot, P L, Morselli
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 19(3)
The autoradiographic distribution, disposition, biliary excretion, and pharmacokinetics of alpidem in Sprague-Dawley rats were evaluated after iv or oral administration. Following i.v. administration, autoradiography showed that radioactivity was pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a5ac84246cdab7ab6170de7c23fb91a
https://pubmed.ncbi.nlm.nih.gov/1680622
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4
Clinical pharmacokinetics and tolerability of alpidem in healthy subjects given increasing single doses
Autor: G. Grasmeijer, Paolo L. Morselli, G. Bianchetti, J. P. Thenot, Ph. Guillet, B. Oosterhuis, Jan H.G. Jonkman, J. F. Thiercelin
Publikováno v: European journal of clinical pharmacology. 41(4)
In a double-blind, placebo-controlled, cross-over experiment in 21 healthy male volunteers, aged 19 to 27 y, the pharmacokinetics and tolerance of the new anxiolytic drug alpidem (SL80.0342) and its three major metabolites were studied after single d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693a2e7e077994df56f57cf2518f9de4
https://pubmed.ncbi.nlm.nih.gov/1687121
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5
Identification of the rabbit and human cytochromes P-450IIIA as the major enzymes involved in the N-demethylation of diltiazem
Autor: L, Pichard, G, Gillet, I, Fabre, I, Dalet-Beluche, C, Bonfils, J P, Thenot, P, Maurel
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 18(5)
Oxidative metabolism of diltiazem (DTZ), a calcium channel blocker, was investigated in rabbit and human liver microsomes as well as in primary cultures of human hepatocytes. DTZ N-demethylation, the major metabolic pathway in man, was strongly incre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f1bca65ed47f9bb4036beb279d7a070f
https://pubmed.ncbi.nlm.nih.gov/1981725
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6
Akademický článek
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7
Design of a continuous-flow fast atom bombardment probe for a Nermag R10-10C mass spectrometer
Autor: G. Gillet, S. Vajta, P. Padovani, J P Thenot
Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 562:747-748
A probe for continuous-flow fast atom bombardment (FAB) was designed to fit a Nermag R10-10C mass spectrometer. It is made of a 1 m × 0.050 mm i.d. fused-silica capillary inserted through a 0.3 mm i.d. hole drilled axially in the copper FAB target.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61cb1980277ffaf73f879284fbaa486
https://doi.org/10.1016/0378-4347(91)80627-o
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9
Metabolism of diethylstilbestrol in the C3H mouse: Chromatographic systems for the quantitative analysis of DES metabolic products
Autor: B.J. Gough, J.‐P. Thenot, E. D. Helton, E.C. Horning, J.W. King
Publikováno v: Steroids. 31:471-484
Initial excretion studies with orally administered [monoethyl-1- 3 H] DES demonstrated the feces to be the principal mode of elimination of DES in the C3H mouse. Metabolic studies with tritiated DES and/or [UL- 14 C] DES were performed with orally do
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d8de4940ee22be477ee57350e6c0ec
https://doi.org/10.1016/0039-128x(78)90029-6
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10
Gas phase analytical methods for the study of human metabolites
Autor: C.D. Pfaffenberger, J. Szafranek, A. L. German, P. van Hout, Marjorie G. Horning, J.-P. Thenot, Evan C. Horning
Publikováno v: Journal of Chromatography A. 91:367-378
A method has been developed for the preparation of high-resolution (100,000 or more theoretical plates), thermostable glass open tubular capillary columns. The key to column preparation lies in the inclusion of silanized silica particles (Silanox, 6
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85d0910cdd4b1e72bab37f24afb1b837
https://doi.org/10.1016/s0021-9673(01)97915-4
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