Zobrazeno 1 - 10
of 147
pro vyhledávání: '"J.‐M. Arrang"'
Autor:
J.‐M. Arrang, V. Armand
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 5, Pp n/a-n/a (2024)
Abstract This study attempted to clarify the role of histamine H1 receptors in epilepsy by exploring the effects of agonists and inverse agonists on the rundown of the current induced by iterative applications of NMDA or GABA in primary neuronal cult
Externí odkaz:
https://doaj.org/article/9ece8c870aa54167a1383d2392de3757
Akademický článek
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The objective was to explore the epileptogenic effects of several drugs specific to the antihistaminic H1 receptor on NMDA and GABA responses. With patch-clamp whole-cell recordings of hippocampal neurons of rats, we observe the effects of several hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::402dff5f6ff4ffc77778a6dd1f7ef1e6
https://doi.org/10.1101/2021.11.02.466417
https://doi.org/10.1101/2021.11.02.466417
Autor:
J.-M. Arrang
Publikováno v:
Annales Pharmaceutiques Françaises. 65:275-284
The histamine H3 receptor was identified in the 80's by our group as a presynaptic autoreceptor inhibiting histamine synthesis and release in the rat brain. Sixteen years later, cloning of the related human H3 receptor revealed the existence of isofo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2e9121d06d5fbc587382b232e3f0a5c
https://doi.org/10.1016/s0003-4509(07)90047-4
https://doi.org/10.1016/s0003-4509(07)90047-4
Autor:
M. Garbarg, Schwartz Jc, Y. S. Khalaf, X. Ligneau, W. Tertiuk, J.‐M. Arrang, S. K. Hosseini, Charon Robin Ganellin
Publikováno v:
Journal of Medicinal Chemistry. 38:3342-3350
Starting from thioperamide, the first potent and selective H 3 -receptor histamine antagonist, analogues have been synthesized and tested in vitro on rat cerebral cortex to explore structure-activity relationships. The aim has been to design potent c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e770fa7029b495e58f5fc3ede1e5147
https://doi.org/10.1021/jm00017a018
https://doi.org/10.1021/jm00017a018
Publikováno v:
European Journal of Medicinal Chemistry. 30:219-225
Summary In search for potential histamine H3-receptor agonists a series of mono- and dialkyl-substituted histamine derivatives was synthesized. All target compounds were tested in vitro for their agonist activity at H3-, H2-, and H1-receptors. Introd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::170d4395b0dff5529eb27edd95e87d2f
https://doi.org/10.1016/0223-5234(96)88228-6
https://doi.org/10.1016/0223-5234(96)88228-6
Publikováno v:
British journal of pharmacology. 166(6)
BACKGROUND AND PURPOSE The histamine H(3) receptor was identified as the autoreceptor of brain histaminergic neurons. After its cloning, functional H(3) receptor isoforms generated by a deletion in the third intracellular loop were found in the brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::425628458530ae606c4d0fd76ecc23c2
https://pubmed.ncbi.nlm.nih.gov/22356432
https://pubmed.ncbi.nlm.nih.gov/22356432
Autor:
Charon Robin Ganellin, N. Defontaine, D. Jayes, Schwartz Jc, W. Tertiuk, J.‐M. Arrang, Y. S. Khalaf
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::916f0be97a236b690bb3e0a825e97ae3
https://doi.org/10.1002/chin.199209206
https://doi.org/10.1002/chin.199209206
Publikováno v:
ChemInform. 26
Summary In search for potential histamine H3-receptor agonists a series of mono- and dialkyl-substituted histamine derivatives was synthesized. All target compounds were tested in vitro for their agonist activity at H3-, H2-, and H1-receptors. Introd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cd7f4439117e809f7958dbb1871fdc3
https://doi.org/10.1002/chin.199534267
https://doi.org/10.1002/chin.199534267
Autor:
Y. S. Khalaf, J.‐M. Arrang, Charon Robin Ganellin, S. K. Hosseini, X. Ligneau, M. Garbarg, W. Tertiuk, Schwartz Jc
Publikováno v:
ChemInform. 26
Starting from thioperamide, the first potent and selective H 3 -receptor histamine antagonist, analogues have been synthesized and tested in vitro on rat cerebral cortex to explore structure-activity relationships. The aim has been to design potent c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6966487a758d78ecd97758427404e67c
https://doi.org/10.1002/chin.199551135
https://doi.org/10.1002/chin.199551135