Pitolisant long term effect in sleepy obstructive sleep apnea patients with CPAP

Autor: J.-L. Pépin, O. Georgiev, R. Tiholov, V. Attali, J. Verbraecken, B. Buyse, M. Partinen, I. Fietze, G. Belev, D. Dokic, R. Tamisier, P. Lévy, I. Lecomte, J.-M. Lecomte, J.-C. Schwartz, Y. Dauvilliers

Publikováno v: Sleep Medicine. 100:S265-S266

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28d4fea302c87c80b30c6c7ca8db6eee
https://doi.org/10.1016/j.sleep.2022.05.716

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Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies

Autor: Pierre Maison-Blanche, Xavier Ligneau, Jean-François Faivre, J C Schwartz, Gary R. Mirams, Jeanne-Marie Lecomte, Rashmi R. Shah, Isabelle Berrebi-Bertrand, Laurent Landais, Philippe Robert

Publikováno v: British Journal of Pharmacology. 174:4449-4463

Background and purpose: We evaluated the concordance of results from two sets of nonclinical cardiovascular safety studies on pitolisant. Experimental approach: Nonclinical studies envisaged both in the ICH S7B guideline and Comprehensive in vitro Pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0baf92db8dfb31cccbc65218d0614fe9
https://doi.org/10.1111/bph.14047

The histamine H3 receptor: from discovery to clinical trials with pitolisant

Autor: J C Schwartz

Publikováno v: British Journal of Pharmacology. 163:713-721

The third histamine receptor was discovered in 1983 by a traditional pharmacological approach, consisting of assessing the inhibitory effect of histamine on its own release from depolarized rat brain slices. The same in vitro test was used to design,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6078abd60b3c4a1b86bb544427ff866e
https://doi.org/10.1111/j.1476-5381.2011.01286.x

Synthesis and evaluation of amides surrogates of dopamine D3 receptor ligands

Autor: Denis Danvy, Mickael Jean, Philippe Robert, J.-C. Schwartz, Thierry Calmels, Marc Capet, Nicolas Levoin, Jacques Renault, Philippe Uriac, Isabelle Berrebi-Bertrand, J.M. Lecomte

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2010, 20 (18), pp.5376-9. ⟨10.1016/j.bmcl.2010.07.096⟩
Bioorganic and Medicinal Chemistry Letters, 2010, 20 (18), pp.5376-9. ⟨10.1016/j.bmcl.2010.07.096⟩

International audience; Isosteric replacement of the amide function and modulation of the arylpiperazine moiety of known dopamine D3 receptor ligands led to potent and selective compounds. Enhanced bioavailability and preferential brain distribution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9222bfc5cd67f9255285875f12e25a
https://doi.org/10.1016/j.bmcl.2010.07.096