Zobrazeno 1 - 10
of 140
pro vyhledávání: '"J. Michael Lord"'
Autor:
Robert A. Spooner, J. Michael Lord
Publikováno v:
Toxins, Vol 7, Iss 1, Pp 49-65 (2015)
The heterodimeric plant toxin ricin binds exposed galactosyls at the cell surface of target mammalian cells, and, following endocytosis, is transported in vesicular carriers to the endoplasmic reticulum (ER). Subsequently, the cell-binding B chain (R
Externí odkaz:
https://doaj.org/article/153aa7b345bd42a48200f4a368297306
Autor:
Robert A. Spooner, J. Michael Lord
Publikováno v:
Toxins, Vol 3, Iss 7, Pp 787-801 (2011)
Ricin is a heterodimeric plant protein that is potently toxic to mammalian and many other eukaryotic cells. It is synthesized and stored in the endosperm cells of maturing Ricinus communis seeds (castor beans). The ricin family has two major members,
Externí odkaz:
https://doaj.org/article/4975e2453bf84e7e9dcd58cb6b7828ba
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41119 (2012)
Escherichia coli Shiga-like toxin 1 normally traffics to the endoplasmic reticulum (ER) in sensitive mammalian cells from where the catalytic A chain (SLTxA1) dislocates to the cytosol to inactivate ribosomes. Currently, no molecular details of the d
Externí odkaz:
https://doaj.org/article/3e467bd503c24aa9930490197ae9259f
Autor:
Mina-Olga Aletrari, Craig McKibbin, Helen Williams, Vidya Pawar, Paola Pietroni, J Michael Lord, Sabine L Flitsch, Roger Whitehead, Eileithyia Swanton, Stephen High, Robert A Spooner
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22713 (2011)
The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates. Toxins such as ricin and Shiga/Shiga-like toxins (SLTx) are endocyt
Externí odkaz:
https://doaj.org/article/5d423c88ef58419e80caaf4f9129e3c2
Autor:
Edward J. Evans, David Harvey, E. Yvonne Jones, David I. Stuart, Max Crispin, J. Michael Lord, Simon J. Davis, Veronica T. Chang, Raymond A. Dwek, Robert A. Spooner
Publikováno v:
The Journal of Biological Chemistry
Disruption of Golgi alpha-mannosidase II activity can result in type II congenital dyserythropoietic anemia and induce lupus-like autoimmunity in mice. Here, we isolated a mutant human embryonic kidney (HEK) 293T cell line called Lec36, which display
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9852d991b8cfa8e0baa269786ca94956
https://ora.ox.ac.uk/objects/uuid:a17ed07b-f90b-4d6d-bbc8-048bb2795a3a
https://ora.ox.ac.uk/objects/uuid:a17ed07b-f90b-4d6d-bbc8-048bb2795a3a
Autor:
J. Michael Lord, Vincenzo Cerundolo, Lynne M. Roberts, P. Rod Dunbar, Karen L. Noakes, Helene Teisserenc
Shiga-like toxin 1 (SLT) from Escherichia coli 0157:H7 enters mammalian cells by endocytosis from the cell surface to the endoplasmic reticulum before translocating into the cytosol. Here, SLT was engineered at its N- or C-terminus to carry a peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68796b8f827eb92972ed5c773e01d6dc
https://ora.ox.ac.uk/objects/uuid:71456674-aca9-4d8a-b9ec-8e179857b7be
https://ora.ox.ac.uk/objects/uuid:71456674-aca9-4d8a-b9ec-8e179857b7be
RNAi Screening of Drosophila (Sophophora) melanogaster S2 Cells for Ricin Sensitivity and Resistance
Autor:
J. Michael Lord, Mahmoud M. Omar, Kevin G. Moffat, Antara De, Sean T. Sweeney, Lynne M. Roberts, Laura Briggs, Vidya Pawar, Robert A. Spooner
Publikováno v:
Journal of Biomolecular Screening
The ribosome-inhibiting toxin ricin binds exposed β1→4 linked galactosyls on multiple glycolipids and glycoproteins on the cell surface of most eukaryotic cells. After endocytosis, internal cell trafficking is promiscuous, with only a small propor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640da760daa3a4edc4ca2221e679d2b4
https://doi.org/10.1177/1087057110397890
https://doi.org/10.1177/1087057110397890
Autor:
Kevin G. Moffat, Graham Ladds, J. Michael Lord, Vilmos Fülöp, Catherine J. Marsden, Stuart C H Allen, Lynne M. Roberts, Katherine A. H. Moore
Publikováno v:
FEBS Journal. 274:5586-5599
Ricin is a heterodimeric plant protein that is potently toxic to mammalian cells. Toxicity results from the catalytic depurination of eukaryotic ribosomes by ricin toxin A chain (RTA) that follows toxin endocytosis to, and translocation across, the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2649686a1f9bcab8ca968ca41462d845
https://doi.org/10.1111/j.1742-4658.2007.06080.x
https://doi.org/10.1111/j.1742-4658.2007.06080.x