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High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells

Autor: Michaela Fontenay, Thomas Farge, J-C Portais, Catherine Lacombe, Mireille Lambert, C Chenevier-Gobeaux, Rudy Birsen, Nicolas Chapuis, François Vergez, Didier Bouscary, Virginie Chesnais, Marine Fraisse, Laury Poulain, Jerome Tamburini, Florence Zylbersztejn, Christelle Debeissat, Thiago Trovati Maciel, Olivier Herault, J-E Sarry, Pierre Sujobert, Sylvain Barreau, Lucille Stuani, Christian Recher, Tony Lionel Palama, Patrick Mayeux, Frédéric Bouillaud

Publikováno v: Leukemia. 31(11)

Alterations in metabolic activities are cancer hallmarks that offer a wide range of new therapeutic opportunities. Here we decipher the interplay between mTORC1 activity and glucose metabolism in acute myeloid leukemia (AML). We show that mTORC1 sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5dcf67661ce10abd92b8b2284634da7
https://pubmed.ncbi.nlm.nih.gov/28280275

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Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells

Autor: Helena Boutzen, N Alet, F Théodoro, F Bono, J-E Sarry, Lindsay Peyriga, Thierry Levade, S Scotland, C Rocher, Stéphane Manenti, Gwenn-ael Danet-Desnoyers, Christian Recher, E Dumon, I Sénégas, Nicolas Skuli, Yvan Martineau, Mary A. Selak, J-C Portais, Elizabeth Micklow, Rémi Peyraud, Christophe Junot, Estelle Saland, F. De Toni, Martin Carroll

Publikováno v: Leukemia
Leukemia, Nature Publishing Group: Open Access Hybrid Model Option B, 2013, 27 (11), pp.2129-2138. ⟨10.1038/leu.2013.107⟩
Leukemia, 2013, 27 (11), pp.2129-2138. ⟨10.1038/leu.2013.107⟩

International audience; Previous reports demonstrate that metformin, an anti-diabetic drug, can decrease the risk of cancer and inhibit cancer cell growth. However, its mechanism in cancer cells is still unknown. Metformin significantly blocks cell c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da21e4f60666408a8b5e9bef6075841
https://pubmed.ncbi.nlm.nih.gov/23568147