Zobrazeno 1 - 10
of 32
pro vyhledávání: '"J van der Spek P"'
Bioinformatic meta-analysis reveals novel differentially expressed genes and pathways in sarcoidosis
Autor:
Rogier T. A. van Wijck, Hari S. Sharma, Sigrid M. A. Swagemakers, Willem A. Dik, Hanna IJspeert, Virgil A. S. H. Dalm, Paul L. A. van Daele, P. Martin van Hagen, Peter J. van der Spek
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionSarcoidosis is a multi-system inflammatory disease of unknown origin with heterogeneous clinical manifestations varying from a single organ non-caseating granuloma site to chronic systemic inflammation and fibrosis. Gene expression studie
Externí odkaz:
https://doaj.org/article/f8a6d8e6b3d74c478ef8b365b23c0637
Autor:
Marie de Bakker, Teun B. Petersen, K. Martijn Akkerhuis, Magdalena Harakalova, Victor A. Umans, Tjeerd Germans, Kadir Caliskan, Peter D. Katsikis, Peter J. van der Spek, Navin Suthahar, Rudolf A. de Boer, Dimitris Rizopoulos, Folkert W. Asselbergs, Eric Boersma, Isabella Kardys
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Background Studies focusing on sex differences in circulating proteins in patients with heart failure with reduced ejection fraction (HFrEF) are scarce. Insight into sex-specific cardiovascular protein profiles and their associations with th
Externí odkaz:
https://doaj.org/article/7452d03e3e184ddc9f2d6d439dc0745f
Autor:
Johanna L. Heinz, Sigrid M. A. Swagemakers, Joanna von Hofsten, Marie Helleberg, Michelle M. Thomsen, Kerstin De Keukeleere, Joke H. de Boer, Tomas Ilginis, Georges M. G. M. Verjans, Peter M. van Hagen, Peter J. van der Spek, Trine H. Mogensen
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
PurposeHerpes simplex virus (HSV) and varicella-zoster virus (VZV) are neurotropic human alphaherpesviruses endemic worldwide. Upon primary infection, both viruses establish lifelong latency in neurons and reactivate intermittently to cause a variety
Externí odkaz:
https://doaj.org/article/2755a6e1e135421ea6420d24946ac46e
Autor:
Teun B. Petersen, Marie de Bakker, Folkert W. Asselbergs, Magdalena Harakalova, K. Martijn Akkerhuis, Jasper J. Brugts, Jan van Ramshorst, R. Thomas Lumbers, Rachel M. Ostroff, Peter D. Katsikis, Peter J. van der Spek, Victor A. Umans, Eric Boersma, Dimitris Rizopoulos, Isabella Kardys
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104655- (2023)
Summary: Background: HFrEF is a heterogenous condition with high mortality. We used serial assessments of 4210 circulating proteins to identify distinct novel protein-based HFrEF subphenotypes and to investigate underlying dynamic biological mechanis
Externí odkaz:
https://doaj.org/article/f7d15c4f779b430a93c911178ae4dfdd
Autor:
Rosario Trifiletti, Herbert M. Lachman, Olivia Manusama, Deyou Zheng, Alberto Spalice, Pietro Chiurazzi, Allan Schornagel, Andreea M. Serban, Rogier van Wijck, Janet L. Cunningham, Sigrid Swagemakers, Peter J. van der Spek
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Abrupt onset of severe neuropsychiatric symptoms including obsessive–compulsive disorder, tics, anxiety, mood swings, irritability, and restricted eating is described in children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS).
Externí odkaz:
https://doaj.org/article/573c1131921f4a5c8e7480f00e905eee
Autor:
Job van Riet, Chinmoy Saha, Nikolaos Strepis, Rutger W. W. Brouwer, Elena S. Martens-Uzunova, Wesley S. van de Geer, Sigrid M. A. Swagemakers, Andrew Stubbs, Yassir Halimi, Sanne Voogd, Arif Mohammad Tanmoy, Malgorzata A. Komor, Youri Hoogstrate, Bart Janssen, Remond J. A. Fijneman, Yashar S. Niknafs, Arul M. Chinnaiyan, Wilfred F. J. van IJcken, Peter J. van der Spek, Guido Jenster, Rogier Louwen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
CRISPR elements in the human genome are expressed in both healthy tissues and tumors but with distinct patterns, representing a potential biomarker for cancer.
Externí odkaz:
https://doaj.org/article/f067cb604205407abac008b0006c1b2e
Autor:
Tanja C W Nijboer, Ellen V S Hessel, Gijs W van Haaften, Martine J van Zandvoort, Peter J van der Spek, Christine Troelstra, Carolien G F de Kovel, Bobby P C Koeleman, Bert van der Zwaag, Eva H Brilstra, J Peter H Burbach
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0290013 (2023)
Colour agnosia is a disorder that impairs colour knowledge (naming, recognition) despite intact colour perception. Previously, we have identified the first and only-known family with hereditary developmental colour agnosia. The aim of the current stu
Externí odkaz:
https://doaj.org/article/437e002c511c4c28b84eb313bb4302a8
Autor:
Maria-Theodora Pandi, Maria Koromina, Iordanis Tsafaridis, Sotirios Patsilinakos, Evangelos Christoforou, Peter J. van der Spek, George P. Patrinos
Publikováno v:
Human Genomics, Vol 15, Iss 1, Pp 1-13 (2021)
Abstract Background The field of pharmacogenomics focuses on the way a person’s genome affects his or her response to a certain dose of a specified medication. The main aim is to utilize this information to guide and personalize the treatment in a
Externí odkaz:
https://doaj.org/article/116be51350a64a59aef0c3ac7fd4cf03
Autor:
Jill de Wit, Rogier T. A. van Wijck, Virgil A. S. H. Dalm, Kristen L. Snyder, Joan E. E. Totté, Suzanne G. M. A. Pasmans, Peter J. van der Spek, the Academic Center of Excellence (ACE) workgroups Allergic Diseases and Rare Immunological Disease Centre (RIDC)
Publikováno v:
Clinical and Translational Allergy, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Background The atopic syndrome consists of heterogeneous manifestations, in which multiple associated genetic loci have recently been identified. It is hypothesized that immune dysregulation plays a role in the pathogenesis. In primary immun
Externí odkaz:
https://doaj.org/article/78337cf0578f4e428b3c719ef009a7a6
Autor:
Sita Virakul, Poorichaya Somparn, Trairak Pisitkun, Peter J. van der Spek, Virgil A. S. H. Dalm, Dion Paridaens, P. Martin van Hagen, Nattiya Hirankarn, Tanapat Palaga, Willem A. Dik
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
BackgroundGraves’ ophthalmopathy (GO) is a frequent extrathyroidal complication of Graves’ hyperthyroidism. Orbital fibroblasts contribute to both orbital tissue inflammation and remodeling in GO, and as such are crucial cellular elements in acti
Externí odkaz:
https://doaj.org/article/59861f5dc9a04b719fa6d6c52440a04c