Výsledky vyhledávání

The minor histocompatibility antigen 1 (HMHA1)/ArhGAP45 is a RacGAP and a novel regulator of endothelial integrity

Autor: Joana Amado-Azevedo, Nathalie R. Reinhard, G.P. van Nieuw Amerongen, Peter L. Hordijk, Victor W.M. van Hinsbergh, J. van Bezu

Publikováno v: Amado-Azevedo, J, Reinhard, N R, van Bezu, J, van Nieuw Amerongen, G P, van Hinsbergh, V W M & Hordijk, P L 2018, ' The minor histocompatibility antigen 1 (HMHA1)/ArhGAP45 is a RacGAP and a novel regulator of endothelial integrity ', Vascular Pharmacology, vol. 101, pp. 38-47 . https://doi.org/10.1016/j.vph.2017.11.007
Vascular Pharmacology, 101, 38-47. Elsevier Inc.

Endothelial cells line the vasculature and act as gatekeepers that control the passage of plasma, macromolecules and cells from the circulation to the interstitial space. Dysfunction of the endothelial barrier can lead to uncontrolled leak or edema.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76822081db90db8fd4a39be93dd962ce
https://doi.org/10.1016/j.vph.2017.11.007

Zobrazit plný text záznamu

Homocysteine-induced inverse expression of tissue factor and DPP4 in endothelial cells is related to NADPH oxidase activity

Autor: H I Korkmaz, K M Jansen, J van Bezu, Paj Krijnen, Hwm Niessen, Ppm van Zuijlen, N E Hahn, Rjp Musters, W N van Wieringen, Mmw Ulrich

Publikováno v: Korkmaz, H I, Hahn, N E, Jansen, K M, Musters, R J P, van Bezu, J, van Wieringen, W N, van Zuijlen, P P M, Ulrich, M M W, Niessen, H W M & Krijnen, P A J 2019, ' Homocysteine-induced inverse expression of tissue factor and DPP4 in endothelial cells is related to NADPH oxidase activity ', Physiology International, vol. 106, no. 1, pp. 29-38 . https://doi.org/10.1556/2060.106.2019.05
Physiology International, 106(1), 29-38. Akademiai Kiado

Purpose We previously found that homocysteine (Hcy)-induced apoptosis in endothelial cells coincided with increased NADPH oxidase (NOX) activity. In addition, in ischemic endothelial cells present in the heart, we showed that loss of serine protease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c0a1f57b035734b91a88b8096b1c9e
https://research.vumc.nl/en/publications/026ee05d-6a7b-45f0-ba49-d2190d8de23b

Zobrazit plný text záznamu

A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity

Autor: Victor W.M. van Hinsbergh, G.P. van Nieuw Amerongen, Victor W. van Beusechem, Nathalie R. Reinhard, Joana Amado-Azevedo, Peter L. Hordijk, Rene X. Menezes, J. van Bezu

Publikováno v: Scientific Reports, 7(1):10132. Nature Publishing Group
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Amado-Azevedo, J, Reinhard, N R, van Bezu, J, Menezes, R X, Van Beusechem, V W, Van Nieuw Amerongen, G P, Van Hinsbergh, V W M & Hordijk, P L 2017, ' A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity ', Scientific Reports, vol. 7, no. 1, 10132 . https://doi.org/10.1038/s41598-017-10392-0

Endothelial barrier function is carefully controlled to protect tissues from edema and damage inflicted by extravasated leukocytes. RhoGTPases, in conjunction with myriad regulatory proteins, exert both positive and negative effects on the endothelia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e2edfb8a00071b8f28323266b57502
https://doi.org/10.1038/s41598-017-10392-0

Zobrazit plný text záznamu

Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retina

Autor: R. O. Schlingemann, J. Van Bezu, J.M. Hughes, C. J. F. Van Noorden, Paul Canning, Casper G. Schalkwijk, E. J. Kuiper, Alan W. Stitt, Ingeborg Klaassen

Publikováno v: Hughes, J M, Kuiper, E J, Klaassen, I, Canning, P, Stitt, A W, Van Bezu, J, Schalkwijk, C G, Van Noorden, C J F & Schlingemann, R O 2007, ' Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retina ', Diabetologia, vol. 50, no. 5, pp. 1089-1098 . https://doi.org/10.1007/s00125-007-0621-4
Diabetologia
Diabetologia, 50(5), 1089-1098. Springer Verlag

Aims/hypothesis Referred to as CCN, the family of growth factors consisting of cystein-rich protein 61 (CYR61, also known as CCN1), connective tissue growth factor (CTGF, also known as CCN2), nephroblastoma overexpressed gene (NOV, also known as CCN3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69be99cad3e72b04028873e733be52e
https://pure.qub.ac.uk/en/publications/advanced-glycation-end-products-cause-increased-ccn-family-and-extracellular-matrix-gene-expression-in-the-diabetic-rodent-retina(ec66cf6e-43df-4f01-a394-f5f67378343d).html

Zobrazit plný text záznamu

The new cardioprotector Monohydroxyethylrutoside protects against doxorubicin-induced inflammatory effects in vitro

Autor: A S Jorna, H M W Verheul, J van Bezu, W.J.F. van der Vijgh, M A I Abou El Hassan, Aalt Bast, Casper G. Schalkwijk

Publikováno v: Abou El Hassan, MA, Verheul, H M W, Jorna, AS, Schalkwijk, C G, van Bezu, J & van der Vijgh, W J F 2003, ' The new cardioprotector Monohydroxyethylrutoside protects against doxorubicin-induced inflammatory effects in vitro. ', British Journal of Cancer, vol. 89, no. 2, pp. 357-62 . https://doi.org/10.1038/sj.bjc.6601022
British Journal of Cancer, 89(2), 357-362. Nature Publishing Group
British Journal of Cancer
British Journal of Cancer, 89(2), 357-62. Nature Publishing Group

The new cardioprotector Monohydroxyethylrutoside protects against doxorubicin-induced inflammatory effects in vitro.Abou El Hassan MA, Verheul HM, Jorna AS, Schalkwijk C, van Bezu J, van der Vijgh WJ, Bast A.Department of Medical Oncology, Free Unive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a96899b74b3001510cc7e0b138970d
https://research.vumc.nl/ws/files/10003515/165386

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání