Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial

Autor: John R Petrie, Nishi Chaturvedi, Ian Ford, Martijn C G J Brouwers, Nicola Greenlaw, Therese Tillin, Irene Hramiak, Alun D Hughes, Alicia J Jenkins, Barbara E K Klein, Ronald Klein, Teik C Ooi, Peter Rossing, Coen D A Stehouwer, Naveed Sattar, Helen M Colhoun, H Nickerson, O Lou, S Dutta, J Haw, C Anderson, S Kean, E Thomson, L Gillespie, J Gibb, N Greenlaw, A Keech, A Jenkins, K March, S Williams, E Coady, M Bots, J Dreyer, T Jan, K Sheffy, R Lusky, S Peleg, A Shore, D Carty, P Donnan, M Witham, A Adler, E Lonn, P Rauchhaus, R Lindsay, M Brouwers, J Van-Melckebeke, T Hamill, L Cuthbertson, A Murray, L Jolly, E Miller, J Hair, A Bell, S Carmichael, E Douglas, P Surtees, E Dinnett, J Allan, C Watson, M McLaughlin, G Brindley, E Smillie, D Motherwell, S MacDonald, P Ellis, D Stuart, M Travers, S Brearley, L Greig, P Colman, A Nankervis, S Forulanos, D West, S Vaughan, M Bjorasen, J Donlan, J Vrazas, D O'Neal, J Horsburgh, H Pater, S Kent, S Twigg, G Fulcher, R Denner, A Piotrowicz, A Januszewski, A Coy, T Paul, C McDonald, S Tereschyn, N Schmidt, M Weingert, H Heard, S Burke, TC Ooi, H Lochnan, A Sorisky, E Keely, J Malcolm, J Maranger, C Favreau, S Petherick, K Boles, P Rossing, TW Hansen, S Lund, B Hemmingsen, N Thorogood, K Green, T Robinson, K Abouglilia, D Nayman, C Miller, R Warren, K Aizawa, M Balasubramani, S Toth, K Harvey, G Birch, S Atkin, T Sathyapalan, A James, Z Javed, J Wilding, B Martin, S Birch, A Wilcox, N Watson, N Oliver, N Jugnee, M Rutter, T Turgut, A Shaju, S Yau, S Subin, M Walker, D Wake, A Millward, P Chong, M Hibbert, J George, N Schaper, J Pinxt, J op het Roodt, Sam Phillips, L Murray, L Sleigh, A Collier, LE Sit, K Allan, J Cook, K Campbell, L Hodge, G Leese, G Reekie, A Jaap, A Sudworth, A White, J McKnight, L Steven, G McKay, A Llano, G Currie, E Lennon, J Johnstone, K Shields

Publikováno v: The Lancet Diabetes & Endocrinology, 5(8), 597-609. Elsevier Science
The Lancet Diabetes & Endocrinology, 5(8), 597. Elsevier BV

BACKGROUND:\ud \ud Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 diabetes, but whether it has cardiovascular benefits is unknown. We aimed to investigate whether metformin treatment (added to titrated insuli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315df881a410b011b5aeac2c3462fc72
https://pubmed.ncbi.nlm.nih.gov/29082883

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