Zobrazeno 1 - 10
of 320
pro vyhledávání: '"J den Hartigh"'
Autor:
Meifan Zhang, Yue S. Yin, Karolline S. May, Shari Wang, Hayley Purcell, Xue-Song Zhang, Martin J. Blaser, Laura J. den Hartigh
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102029- (2024)
Objective: Obesity continues to be a major problem, despite known treatment strategies such as lifestyle modifications, pharmaceuticals, and surgical options, necessitating the development of novel weight loss approaches. The naturally occurring fatt
Externí odkaz:
https://doaj.org/article/1f223635b9e54f81a0ce33acb2e07fbc
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Serum amyloid A (SAA) subtypes 1–3 are well-described acute phase reactants that are elevated in acute inflammatory conditions such as infection, tissue injury, and trauma, while SAA4 is constitutively expressed. SAA subtypes also have been implica
Externí odkaz:
https://doaj.org/article/db98d962053943f28e53b16c3d5821dc
Autor:
Tomas Vaisar, Shari Wang, Mohamed Omer, Angela D. Irwin, Carl Storey, Chongren Tang, Laura J. den Hartigh
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 8, Pp 100241- (2022)
Obesity is associated with inflammation, insulin resistance, and type 2 diabetes, which are major risk factors for CVD. One dietary component of ruminant animal foods, 10,12-conjugated linoleic acid (10,12 CLA), has been shown to promote weight loss
Externí odkaz:
https://doaj.org/article/94f0cd4355a4458183573f30638833bd
Autor:
Diego Gomes, Shari Wang, Leela Goodspeed, Katherine E. Turk, Tomasz Wietecha, Yongjun Liu, Karin E. Bornfeldt, Kevin D. O'Brien, Alan Chait, Laura J. den Hartigh
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 3, Pp 100174- (2022)
Antisense oligonucleotides (ASOs) against Ldl receptor (Ldlr-ASO) represent a promising strategy to promote hypercholesterolemic atherosclerosis in animal models without the need for complex breeding strategies. Here, we sought to characterize and co
Externí odkaz:
https://doaj.org/article/8ffc4aeca8934757a42ccde986d1a313
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2022)
Fibroblast growth factor 21 (FGF21) is a hormone that is involved in the regulation of lipid, glucose, and energy metabolism. Pharmacological FGF21 administration promotes weight loss and improves insulin sensitivity in rodents, non-human primates, a
Externí odkaz:
https://doaj.org/article/17891ec805e64a2eb485fe9d748576eb
Autor:
Chang Yeop Han, Inkyung Kang, Ingrid A. Harten, John A. Gebe, Christina K. Chan, Mohamed Omer, Kimberly M. Alonge, Laura J. den Hartigh, Diego Gomes Kjerulf, Leela Goodspeed, Savitha Subramanian, Shari Wang, Francis Kim, David E. Birk, Thomas N. Wight, Alan Chait
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107818- (2020)
Summary: Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue inflammation in obesity. We find that adipose tissue versican and biglycan increase in obe
Externí odkaz:
https://doaj.org/article/0ab5266a0eec4194a0bd5b3e2ad576af
Autor:
Alan Chait, Laura J. den Hartigh
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date several types of adipose tissue have been identified, namely white, brown, and beige, that reside in various specific anatomical locations throughout the body.
Externí odkaz:
https://doaj.org/article/50a5ff6e044a4d08af229a2334a8f138
Autor:
Laura J. den Hartigh, Leela Goodspeed, Shari A. Wang, Heidi L. Kenerson, Mohamed Omer, Kevin D. O'Brien, Warren Ladiges, Raymond Yeung, Savitha Subramanian
Publikováno v:
Experimental Physiology, Vol 103, Iss 11, Pp 1469-1480 (2018)
New Findings What is the central question of this study? Whether chronic oral rapamycin promotes beneficial effects on glucose/lipid metabolism and energy balance when administered to mice with an obesogenic diet rich in saturated fat and sucrose has
Externí odkaz:
https://doaj.org/article/0d1ac30dac254f139ce9ae2ee60b9052
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227830 (2020)
Estrogens are important for maintaining metabolic health in males. However, the key sources of local estrogen production for regulating energy metabolism have not been fully defined. Immune cells exhibit aromatase activity and are resident in metabol
Externí odkaz:
https://doaj.org/article/53f402a55b064808a1112826da71d4a5
Autor:
Ana P. Valencia, Jeremy A. Whitson, Shari Wang, Leon Nguyen, Laura J. den Hartigh, Peter S. Rabinovitch, David J. Marcinek
Publikováno v:
Nutrients; Volume 14; Issue 21; Pages: 4645
Aging and poor diet are independent risk factors for heart disease, but the impact of high-sucrose (HS) consumption in the aging heart is understudied. Aging leads to impairments in mitochondrial function that result in muscle dysfunction (e.g., card
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a62f7b1ec93c5c54aebea36bcddeab
https://pubmed.ncbi.nlm.nih.gov/36364920
https://pubmed.ncbi.nlm.nih.gov/36364920