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Steroid and G Protein Binding Characteristics of the Seatrout and Human Progestin Membrane Receptor α Subtypes and Their Evolutionary Origins

Autor: Jing Dong, J. de Vlieg, Yefei Pang, Peter M. A. Groenen, Peter Thomas, J. Kelder, Christopher Tubbs, Yong Zhu

Publikováno v: Endocrinology. 148:705-718

A novel progestin receptor (mPR) with seven-transmembrane domains was recently discovered in spotted seatrout and homologous genes were identified in other vertebrates. We show that cDNAs for the mPR alpha subtypes from spotted seatrout (st-mPRalpha)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371df2d9c40ec0db3b58056f37ab5d7a
https://doi.org/10.1210/en.2006-0974

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Identification of functional and unfolding motions of cutinase as obtained from molecular dynamics computer simulations

Autor: H.A.M. Pepermans, R.C. van Schaik, Andrea Amadei, L.D Creveld, H.J.C. Berendsen, J. de Vlieg

Publikováno v: Proteins-Structure Function and Genetics, 33(2), 253-264. Wiley

The implementation of cutinase from Fusarium solani pisi as a fat-stain removing ingredient in laundry washing is hampered by its unfolding in the presence of anionic surfactants. In this work we present molecular dynamics (MD) computer simulations o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dc10a571325235975a4ac72fe60a07
https://doi.org/10.1002/(sici)1097-0134(19981101)33:2<253::aid-prot9>3.0.co

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Cutinase from Fusarium solani pisi Hydrolyzing Triglyceride Analogs. Effect of Acyl Chain Length and Position in the Substrate Molecule on Activity and Enantioselectivity

Autor: G.H. de Haas, J. De Vlieg, Bart C. Koops, H. T. W. M. Van Der Hijden, Maarten Robert Egmond, Hubertus M. Verheij, Ruud C. Cox, M. L. M. Mannesse

Publikováno v: Biochemistry. 34:6400-6407

Triglyceride analogues were synthesized in which one of the primary acyl ester functions has been replaced by an alkyl group and the secondary acyl ester bond has been replaced by an acyl amino bond. The chain length at either position was varied, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98649888a11d3dfbbd5afe4d7bdf60bf
https://doi.org/10.1021/bi00019a020

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Kniha

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Contribution of cutinase serine 42 side chain to the stabilization of the oxyanion transition state

Autor: C. T. Verrips, Chrislaine Martinez, J. De Vlieg, Sonia Longhi, Christian Cambillau, Maarten R. Egmond, Aurélie Nicolas

Publikováno v: Biochemistry. 35(2)

Cutinase from the fungus Fusarium solani pisi is a lipolytic enzyme able to hydrolyze both aggregated and soluble substrates. It therefore provides a powerful tool for probing the mechanisms underlying lipid hydrolysis. Lipolytic enzymes have a catal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358bc1027847cdf15ba2284dda19f776
https://pubmed.ncbi.nlm.nih.gov/8555209

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Engineering surface charges in a subtilisin

Autor: M R, Egmond, W P, Antheunisse, P, Ravestein, A T, Mooren, J, de Vlieg

Publikováno v: Advances in experimental medicine and biology. 379

Introduction of multiple charged amino acid residues in the subtilisin Savinase by genetic engineering allowed us to modify the electrostatic properties of this enzyme in a systematic way. The effects of these charge changes were investigated theoret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e084693a98ae5ca9a4104ce0cf1f589
https://pubmed.ncbi.nlm.nih.gov/8796326

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Cosurfactants lower surface tension of the diglyceride/water interface: A molecular dynamics study

Autor: A.R. van Buuren, D.P Tieleman, Herman J. C. Berendsen, J. de Vlieg

Publikováno v: Langmuir, 12(10), 2570-2579. AMER CHEMICAL SOC

We performed molecular dynamics (MD) simulations of bulk 1,2-dilauroyl-sn-glycerol (DLG) systemsin contact with a water layer. In the DLG oil phase cosurfactants were placed with increasingconcentration: 1-monolauroyl-sn-glycerol (1MG), 2-monolauroyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf354d624499f77d756ac1a1eae6439
https://research.rug.nl/en/publications/9ceddacc-d998-4620-9e02-e48b17376884

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Engineering Surface Charges in a Subtilisin

Autor: P. Ravestein, Maarten Robert Egmond, J. de Vlieg, W. P. Antheunisse, A. T. A. Mooren

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9780306451089

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bce39bc75922bbd846544bf318c4981
https://doi.org/10.1007/978-1-4613-0319-0_23

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Fleksy: a flexible approach to induced fit docking

Autor: J de Vlieg, Markus Wagener, Sander B. Nabuurs

Publikováno v: Journal of Cheminformatics
Journal of Cheminformatics, Vol 2, Iss Suppl 1, p O24 (2010)

Protein receptor rearrangements upon ligand binding are a major complicating factor in structure-based drug design. An accurate prediction of these so-called induced fit phenomena calls for ligand docking and virtual screening approaches capable of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec661f281747a0d1ad24af81d6396e9c
http://europepmc.org/articles/PMC2867133

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