Zobrazeno 1 - 10
of 586
pro vyhledávání: '"J Zipfel"'
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
IntroductionAnesthetic conditioning has been shown to provide neuroprotection in several neurological disorders. Whether anesthetic conditioning provides protection against peripheral nerve injuries remains unknown. The aim of our current study is to
Externí odkaz:
https://doaj.org/article/28d50e72385f49f0964d2439839b34d7
Autor:
Thomas F. Barrett, Bhuvic Patel, Saad M. Khan, Riley D. Z. Mullins, Aldrin K. Y. Yim, Sangami Pugazenthi, Tatenda Mahlokozera, Gregory J. Zipfel, Jacques A. Herzog, Michael R. Chicoine, Cameron C. Wick, Nedim Durakovic, Joshua W. Osbun, Matthew Shew, Alex D. Sweeney, Akash J. Patel, Craig A. Buchman, Allegra A. Petti, Sidharth V. Puram, Albert H. Kim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Vestibular schwannomas (VS) are benign tumors that lead to significant neurologic and otologic morbidity. How VS heterogeneity and the tumor microenvironment (TME) contribute to VS pathogenesis remains poorly understood. In this study, we pe
Externí odkaz:
https://doaj.org/article/04db7437a9cc4724883e4e3f2bf21c43
Autor:
Meizi Liu, Keshav Jayaraman, Aaron J. Norris, Ahmed Hussein, James W. Nelson, Jogender Mehla, Deepti Diwan, Ananth Vellimana, Yousef Abu‐Amer, Gregory J. Zipfel, Umeshkumar Athiraman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 14 (2023)
Background Recent evidence implicates inflammation as a key driver in delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage (SAH). Inducible nitric oxide synthase (iNOS) is one of the known major mediators of inflammation. We previously
Externí odkaz:
https://doaj.org/article/bdf8c2085ff84924a699b42cb9ad5e00
Autor:
Anthony Z. Wang, Jay A. Bowman-Kirigin, Rupen Desai, Liang-I Kang, Pujan R. Patel, Bhuvic Patel, Saad M. Khan, Diane Bender, M. Caleb Marlin, Jingxian Liu, Joshua W. Osbun, Eric C. Leuthardt, Michael R. Chicoine, Ralph G. Dacey, Gregory J. Zipfel, Albert H. Kim, David G. DeNardo, Allegra A. Petti, Gavin P. Dunn
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-25 (2022)
Abstract Background Recent investigations of the meninges have highlighted the importance of the dura layer in central nervous system immune surveillance beyond a purely structural role. However, our understanding of the meninges largely stems from t
Externí odkaz:
https://doaj.org/article/c17233161de54fbe91f8411660beec7a
Autor:
Meizi Liu, Keshav Jayaraman, James W. Nelson, Jogender Mehla, Deepti Diwan, Ananth K. Vellimana, Gregory J. Zipfel, Umeshkumar Athiraman
Publikováno v:
Diseases, Vol 11, Iss 4, p 130 (2023)
Delayed cerebral ischemia (DCI) is an important contributor to poor outcomes in aneurysmal subarachnoid hemorrhage (SAH) patients. We previously showed that volatile anesthetics such as isoflurane, sevoflurane and desflurane provided robust protectio
Externí odkaz:
https://doaj.org/article/703fc95edf794188ab4d41cff5f09f5f
Autor:
Jogender Mehla, Itender Singh, Deepti Diwan, James W. Nelson, Molly Lawrence, Eunjae Lee, Adam Q. Bauer, David M. Holtzman, Gregory J. Zipfel
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract Previous reports indicate a potential role for signal transducer and activator of transcription 3 (STAT3) in amyloid-β (Aβ) processing and neuritic plaque pathogenesis. In the present study, the impact of STAT3 inhibition on cognition, cer
Externí odkaz:
https://doaj.org/article/33e4d8191d1d435b9f18d426a1f31ded
Autor:
Chihiro Sato, Nipun Mallipeddi, Nupur Ghoshal, Brenton A. Wright, Gregory S. Day, Albert A. Davis, Albert H. Kim, Gregory J. Zipfel, Randall J. Bateman, Audrey Gabelle, Nicolas R. Barthélemy
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 9, Pp 1817-1830 (2021)
Abstract Objective Tau hyperphosphorylation at threonine 217 (pT217) in cerebrospinal fluid (CSF) has recently been linked to early amyloidosis and could serve as a highly sensitive biomarker for Alzheimer’s disease (AD). However, it remains unclea
Externí odkaz:
https://doaj.org/article/11eeb562e9e94caa965224e960d99793
Autor:
Meizi Liu, Keshav Jayaraman, Jogender Mehla, Deepti Diwan, James W. Nelson, Ahmed E. Hussein, Ananth K. Vellimana, Yousef Abu-Amer, Gregory J. Zipfel, Umeshkumar Athiraman
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1163 (2023)
Delayed cerebral ischemia (DCI) is the largest treatable cause of poor outcome after aneurysmal subarachnoid hemorrhage (SAH). Nuclear Factor Kappa-light-chain-enhancer of Activated B cells (NF-kB), a transcription factor known to function as a pivot
Externí odkaz:
https://doaj.org/article/de7776b9f2a049e9baab28b686714910
Autor:
David C. Lauzier, Keshav Jayaraman, Jane Y. Yuan, Deepti Diwan, Ananth K. Vellimana, Joshua W. Osbun, Arindam R. Chatterjee, Umeshkumar Athiraman, Rajat Dhar, Gregory J. Zipfel
Publikováno v:
Stroke. 54:1426-1440
Aneurysmal subarachnoid hemorrhage is a devastating condition causing significant morbidity and mortality. While outcomes from subarachnoid hemorrhage have improved in recent years, there continues to be significant interest in identifying therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::686d1638d5f79df242712c2eca75ac55
https://doi.org/10.1161/strokeaha.122.040072
https://doi.org/10.1161/strokeaha.122.040072
Autor:
Mareshah N. Sowah, Anthony T. Fuller, Stephanie H. Chen, Barth A. Green, Michael E. Ivan, Henri R. Ford, Gregory J. Zipfel, Brenton Pennicooke, Nicholas Theodore, Allan D. Levi
Publikováno v:
Journal of Neurosurgery. :1-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22c46d0d3da96e3e64adddc558c0a013
https://doi.org/10.3171/2023.1.jns221853
https://doi.org/10.3171/2023.1.jns221853