Zobrazeno 1 - 10
of 653
pro vyhledávání: '"J Zapatero"'
Autor:
Kris Gerard Alvarez, Lisa Goral, Abdulhadi Suwandi, Lisa Lasswitz, Francisco J. Zapatero-Belinchón, Katrin Ehrhardt, Kumar Nagarathinam, Katrin Künnemann, Thomas Krey, Agnes Wiedemann, Gisa Gerold, Guntram A. Grassl
Publikováno v:
Virulence (2024)
Human CD81 and CD9 are members of the tetraspanin family of proteins characterized by a canonical structure of four transmembrane domains and two extracellular loop domains. Tetraspanins are known as molecular facilitators, which assemble and organiz
Externí odkaz:
https://doaj.org/article/9dea300125274fc9b995bc95c8ce982c
Autor:
Belén Carriquí-Madroñal, Julie Sheldon, Mara Duven, Cora Stegmann, Karsten Cirksena, Emanuel Wyler, Francisco J Zapatero-Belinchón, Florian W R Vondran, Gisa Gerold
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011759 (2023)
Hepatitis C virus (HCV) exploits the four entry factors CD81, scavenger receptor class B type I (SR-BI, also known as SCARB1), occludin, and claudin-1 as well as the co-factor epidermal growth factor receptor (EGFR) to infect human hepatocytes. Here,
Externí odkaz:
https://doaj.org/article/76780a28da144d5ead51c0d30a884af0
Autor:
Baxolele Mhlekude, Dylan Postmus, Saskia Stenzel, January Weiner, Jenny Jansen, Francisco J Zapatero-Belinchón, Ruth Olmer, Anja Richter, Julian Heinze, Nicolas Heinemann, Barbara Mühlemann, Simon Schroeder, Terry C Jones, Marcel A Müller, Christian Drosten, Andreas Pich, Volker Thiel, Ulrich Martin, Daniela Niemeyer, Gisa Gerold, Dieter Beule, Christine Goffinet
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011657 (2023)
Inhibitors of bromodomain and extra-terminal proteins (iBETs), including JQ-1, have been suggested as potential prophylactics against SARS-CoV-2 infection. However, molecular mechanisms underlying JQ-1-mediated antiviral activity and its susceptibili
Externí odkaz:
https://doaj.org/article/68f2a8478fe7484fafc679780534d4ce
Autor:
Lisa Lasswitz, Francisco J. Zapatero-Belinchón, Rebecca Moeller, Kirsten Hülskötter, Timothée Laurent, Lars-Anders Carlson, Christine Goffinet, Graham Simmons, Wolfgang Baumgärtner, Gisa Gerold
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Chikungunya virus (CHIKV) is an arthritogenic reemerging virus replicating in plasma membrane-derived compartments termed “spherules.” Here, we identify the human transmembrane protein CD81 as host factor required for CHIKV replication.
Externí odkaz:
https://doaj.org/article/d93b517ce2894b59bbb422aa8e6efc0e
Autor:
Francisco J. Zapatero-Belinchón, Rebecca Moeller, Lisa Lasswitz, Marco van Ham, Miriam Becker, Graham Brogden, Ebba Rosendal, Wenjie Bi, Belén Carriquí-Madroñal, Koushikul Islam, Annasara Lenman, Antonia P. Gunesch, Jared Kirui, Thomas Pietschmann, Anna K. Överby, Lothar Jänsch, Gisa Gerold
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103469- (2021)
Summary: Clinical data of patients suffering from COVID-19 indicates that statin therapy, used to treat hypercholesterolemia, is associated with a better disease outcome. Whether statins directly affect virus replication or influence the clinical out
Externí odkaz:
https://doaj.org/article/34bc37bb80fe4e8db30733cdbb761e1b
Autor:
Melanie Ricke-Hoch, Elisabeth Stelling, Lisa Lasswitz, Antonia P. Gunesch, Martina Kasten, Francisco J. Zapatero-Belinchón, Graham Brogden, Gisa Gerold, Thomas Pietschmann, Virginie Montiel, Jean-Luc Balligand, Federica Facciotti, Emilio Hirsch, Thomas Gausepohl, Husni Elbahesh, Guus F. Rimmelzwaan, Anne Höfer, Mark P. Kühnel, Danny Jonigk, Julian Eigendorf, Uwe Tegtbur, Lena Mink, Michaela Scherr, Thomas Illig, Axel Schambach, Tobias J. Pfeffer, Andres Hilfiker, Axel Haverich, Denise Hilfiker-Kleiner
Publikováno v:
PLoS ONE, Vol 16, Iss 8 (2021)
The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostagland
Externí odkaz:
https://doaj.org/article/2229a694ec8a40d4ab4e27c79d308d6b
Autor:
Francisco J. Zapatero-Belinchón, Rina Ötjengerdes, Julie Sheldon, Benjamin Schulte, Belén Carriquí-Madroñal, Graham Brogden, Laura M. Arroyo-Fernández, Florian W. R. Vondran, Benjamin Maasoumy, Thomas von Hahn, Gisa Gerold
Publikováno v:
Cells, Vol 10, Iss 7, p 1626 (2021)
The HCV replication cycle is tightly associated with host lipid metabolism: Lipoprotein receptors SR-B1 and LDLr promote entry of HCV, replication is associated with the formation of lipid-rich membranous organelles and infectious particle assembly h
Externí odkaz:
https://doaj.org/article/93c5e714c9fa4995969c246c9efea10b
Autor:
Isha Singh, Fengling Li, Elissa Fink, Irene Chau, Alice Li, Annía Rodriguez-Hernández, Isabella Glenn, Francisco J. Zapatero-Belinchón, Mario Rodriguez, Kanchan Devkota, Zhijie Deng, Kris White, Xiaobo Wan, Nataliya A. Tolmachova, Yurii S. Moroz, H. Ümit Kaniskan, Melanie Ott, Adolfo Gastía-Sastre, Jian Jin, Danica Galonić Fujimori, John J. Irwin, Masoud Vedadi, Brian K. Shoichet
An under-explored target for SARS-CoV-2 is non-structural protein 14 (Nsp14), a crucial enzyme for viral replication that catalyzes the methylation ofN7-guanosine of the viral RNA at 5′-end; this enables the virus to evade the host immune response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd333c8b593e763c3c9b754e922e14bc
https://doi.org/10.1101/2023.01.12.523677
https://doi.org/10.1101/2023.01.12.523677
Autor:
Vania Passos, Lisa M. Henkel, Jiayi Wang, Francisco J. Zapatero-Belinchón, Rebecca Möller, Guorong Sun, Inken Waltl, Birgit Ritter, Kai A. Kropp, Shuyong Zhu, Michela Deleidi, Ulrich Kalinke, Günter Höglinger, Gisa Gerold, Florian Wegner, Abel Viejo-Borbolla
Severe acute respiratory coronavirus 2 (SARS-CoV-2) infection causes neurological disease in some patients suggesting that infection can affect both the peripheral and central nervous system (PNS and CNS, respectively). It is not clear whether the ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82484edd13c9c65b93d470c8a59e31c2
https://doi.org/10.1101/2022.11.18.517047
https://doi.org/10.1101/2022.11.18.517047
Autor:
M.D. De Las Peñas Cabrera, S. Payano Hernandez, P. Samper Ots, E. Amaya Escobar, J. Zapatero Ortuño
Publikováno v:
Radiotherapy and Oncology. 170:S1019-S1021