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Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non-myeloablative regimen and CD154 blockade

Autor: L, Bühler, S, Deng, J, O'Neil, H, Kitamura, M, Koulmanda, A, Baldi, J, Rahier, I P J, Alwayn, J Z, Appel, M, Awwad, D H, Sachs, G, Weir, J P, Squifflet, D K C, Cooper, Ph, Morel

Publikováno v: Xenotransplantation, Vol. 9, No 1 (2002) pp. 3-13

The aim of the present study was to assess the survival of adult porcine islets transplanted into baboons receiving either (I) conventional triple drug immunosuppressive therapy or (2) a non-myeloablative regimen and an anti-CD154 monoclonal antibody

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::894999af3450a1f2c92f630a0a762e4f
https://archive-ouverte.unige.ch/unige:45714

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Mechanisms of thrombotic microangiopathy following xenogeneic hematopoietic progenitor cell transplantation

Autor: I P, Alwayn, L, Buhler, J Z, Appel, C, Goepfert, E, Csizmadia, L, Correa, D, Harper, H, Kitamura, J, Down, M, Awwad, R, Sackstein, D K, Cooper, S C, Robson

Publikováno v: Transplantation, Vol. 71, No 11 (2001) pp. 1601-9

Attempts to induce tolerance though mixed hematopoietic chimerism in the discordant pig-to-baboon xenotransplantation model are sometimes complicated by a potentially fatal thrombotic microangiopathy in the recipient baboons. This state develops imme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8e424f7cc9843b39b5d8a2a89d8e8fa5
https://archive-ouverte.unige.ch/unige:46855

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Inhibition of platelet aggregation in baboons: therapeutic implications for xenotransplantation

Autor: I P, Alwayn, J Z, Appel, C, Goepfert, L, Buhler, D K, Cooper, S C, Robson

Publikováno v: Xenotransplantation, Vol. 7, No 4 (2000) pp. 247-57

Activation of endothelial cells and platelet sequestration play major roles in rejection of xenografts. The histopathology of both hyperacute and acute vascular or delayed rejection of vascularized discordant xenografts is characterized by interstiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7e787c5db860df4371a292e255268883
https://archive-ouverte.unige.ch/unige:48408

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