Výsledky vyhledávání

Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor

Autor: S Wei, J H Liu, P K Epling-Burnette, A M Gamero, D Ussery, E W Pearson, M E Elkabani, J I Diaz, J Y Djeu

Publikováno v: The Journal of Immunology. 157:5155-5162

The signal pathway for control of apoptosis in human neutrophils is currently unknown. In this study, we provide the first evidence that a Src family tyrosine kinase, Lyn, plays a key role in inhibition polymorphonuclear (PMN) cell death. Several nuc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ce0437cd08adb7ce63386d86f82903d
https://doi.org/10.4049/jimmunol.157.11.5155

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Direct tumoricidal function against human ovarian carcinoma by interferon-gamma- and tumor necrosis factor-alpha-activated human peritoneal mesothelial cells

Autor: D.P.J. Barton, William S. Roberts, D. K. Blanchard, J. Y. Djeu, M. B. Michelini-Norris

Publikováno v: International Journal of Gynecological Cancer. 6:27-37

We report in this study that human peritoneal mesothelial cells can lyse human malignant ovarian cells. Recombinant human interferon (IFN)-γ and rhTNF-α significantly activated cytotoxicity of mesothelial cells against the tumor necrosis factor (TN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::418f32920ec74eb27950bc0f7339e54f
https://doi.org/10.1046/j.1525-1438.1996.06010027.x

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An 5 1 -like integrin receptor mediates the binding of less pathogenic Candida species to fibronectin

Autor: M Piccoli, Giorgio Santoni, L J Hong, J Y Djeu, P Birarelli, A Gamero

Publikováno v: Journal of Medical Microbiology. 43:360-367

The present study was undertaken to investigate whether less pathogenic Candida species (C. tropicalis, C. stellatoidea, C. krusei and C. glabrata) express a fibronectin receptor (FNr) antigenically related to alpha 5 beta 1 integrin, which mediates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435fca10c70b4f3009bea99d191f768e
https://doi.org/10.1099/00222615-43-5-360

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Induction of IL-8 gene expression in human polymorphonuclear neutrophils by recombinant IL-2

Autor: S Wei, J H Liu, D K Blanchard, J Y Djeu

Publikováno v: The Journal of Immunology. 152:3630-3636

Induction of IL-8 gene expression was investigated in IL-2-stimulated circulating peripheral blood polymorphonuclear neutrophils (PMN). Brief exposure of normal PMN to human rIL-2 enhanced both transcriptional and translational expression of IL-8. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2715f68101b98255bef6e7952a6aff20
https://doi.org/10.4049/jimmunol.152.7.3630

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Serum Soluble Interleukin-2 Receptor α Levels in Patients With Gynecologic Cancers: Early Effect of Surgery

Autor: J. V. Fiorica, B. Michelini-Norris, W. S. Roberts, S. V. Nicosia, D. P. J. Barton, D. Cavanagh, J. Y. Djeu, D. K. Blanchard, M. S. Hoffman

Publikováno v: American Journal of Reproductive Immunology. 30:202-206

PROBLEM: To determine the early effect of abdominal cytoreductive surgery on serum soluble interleukin-2 receptor alpha (sIL-2R alpha) levels in patients with ovarian and cervical cancer, and to determine if the extent of cytoreduction correlated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0a37a88f885841bab96d007d5f00dd
https://doi.org/10.1111/j.1600-0897.1993.tb00621.x

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Activation of tumor necrosis factor-alpha production from human neutrophils by IL-2 via IL-2-R beta

Autor: S Wei, D K Blanchard, J H Liu, W J Leonard, J Y Djeu

Publikováno v: The Journal of Immunology. 150:1979-1987

In addition to T cells, NK cells, B cells, and monocytes, we provide new evidence that human polymorphonuclear neutrophils (PMN) can be functionally activated by IL-2 via binding to IL-2R beta expressed on the cell surface. Brief exposure of normal P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::456eb21658cea7f0a66cc990018683dc
https://doi.org/10.4049/jimmunol.150.5.1979

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Function associated with IL-2 receptor-beta on human neutrophils. Mechanism of activation of antifungal activity against Candida albicans by IL-2

Autor: J Y Djeu, J H Liu, S Wei, H Rui, C A Pearson, W J Leonard, D K Blanchard

Publikováno v: The Journal of Immunology. 150:960-970

Polymorphonuclear neutrophils (PMN) are essential components of the host defense system against a wide variety of pathogens. We report here the novel finding that freshly isolated human PMN constitutively express detectable surface levels of IL-2R be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa46181470163052f1e2275b321d2bac
https://doi.org/10.4049/jimmunol.150.3.960

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Lactoferrin release and interleukin-1, interleukin-6, and tumor necrosis factor production by human polymorphonuclear cells stimulated by various lipopolysaccharides: relationship to growth inhibition of Candida albicans

Autor: Antonio Cassone, D Serbousek, C A Pearson, J Y Djeu, Carla Palma

Publikováno v: Scopus-Elsevier

Lipopolysaccharides (LPSs) from Escherichia coli, Serratia marcescens, and Salmonella typhimurium, at doses from 1 to 100 ng/ml, strongly enhanced growth inhibition of Candida albicans by human polymorphonuclear leukocytes (PMN) in vitro. Flow cytome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5310ba6b324b34747cf3d55da8735d4f
https://doi.org/10.1128/iai.60.11.4604-4611.1992

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IFN-gamma enhances sensitivity of human macrophages to extracellular ATP-mediated lysis

Autor: D K Blanchard, S McMillen, J Y Djeu

Publikováno v: The Journal of Immunology. 147:2579-2585

In an effort to determine the mechanism by which autologous monocytes are killed by lymphokine-activated killer cells, soluble mediators were examined for their direct effect on target cells. Extracellular ATP (ATPo), but not ADP, was found to lyse h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::018418234bf29387318c038593950ba9
https://doi.org/10.4049/jimmunol.147.8.2579

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