Zobrazeno 1 - 10
of 5 071
pro vyhledávání: '"J Wade"'
Publikováno v:
eLife, Vol 10 (2021)
Removal of damaged organelles via the process of selective autophagy constitutes a major form of cellular quality control. Damaged organelles are recognized by a dedicated surveillance machinery, leading to the assembly of an autophagosome around the
Externí odkaz:
https://doaj.org/article/40c546596589465a886eb24ae957f951
Autor:
Niladri K Sinha, Alban Ordureau, Katharina Best, James A Saba, Boris Zinshteyn, Elayanambi Sundaramoorthy, Amit Fulzele, Danielle M Garshott, Timo Denk, Matthias Thoms, Joao A Paulo, J Wade Harper, Eric J Bennett, Roland Beckmann, Rachel Green
Publikováno v:
eLife, Vol 9 (2020)
Translation of aberrant mRNAs induces ribosomal collisions, thereby triggering pathways for mRNA and nascent peptide degradation and ribosomal rescue. Here we use sucrose gradient fractionation combined with quantitative proteomics to systematically
Externí odkaz:
https://doaj.org/article/900a514023304981b6374d2c536978ff
Publikováno v:
PLoS Genetics, Vol 15, Iss 12, p e1008489 (2019)
Despite strong vetting for disease activity, only 10% of candidate new molecular entities in early stage clinical trials are eventually approved. Analyzing historical pipeline data, Nelson et al. 2015 (Nat. Genet.) concluded pipeline drug targets wit
Externí odkaz:
https://doaj.org/article/64c49fc6d37349d0a171a41b9bbb335d
Autor:
Virginia Guarani, Claude Jardel, Dominique Chrétien, Anne Lombès, Paule Bénit, Clémence Labasse, Emmanuelle Lacène, Agnès Bourillon, Apolline Imbard, Jean-François Benoist, Imen Dorboz, Mylène Gilleron, Eric S Goetzman, Pauline Gaignard, Abdelhamid Slama, Monique Elmaleh-Bergès, Norma B Romero, Pierre Rustin, Hélène Ogier de Baulny, Joao A Paulo, J Wade Harper, Manuel Schiff
Publikováno v:
eLife, Vol 5 (2016)
Previously, we identified QIL1 as a subunit of mitochondrial contact site (MICOS) complex and demonstrated a role for QIL1 in MICOS assembly, mitochondrial respiration, and cristae formation critical for mitochondrial architecture (Guarani et al., 20
Externí odkaz:
https://doaj.org/article/c2eb5d8eb5b14293a741ed6e1db3525a
Autor:
Saravanapriah Nadarajan, Firaz Mohideen, Yonatan B Tzur, Nuria Ferrandiz, Oliver Crawley, Alex Montoya, Peter Faull, Ambrosius P Snijders, Pedro R Cutillas, Ashwini Jambhekar, Michael D Blower, Enrique Martinez-Perez, J Wade Harper, Monica P Colaiacovo
Publikováno v:
eLife, Vol 5 (2016)
Asymmetric disassembly of the synaptonemal complex (SC) is crucial for proper meiotic chromosome segregation. However, the signaling mechanisms that directly regulate this process are poorly understood. Here we show that the mammalian Rho GEF homolog
Externí odkaz:
https://doaj.org/article/4df71421871c44c4a4879464b70529bc
Publikováno v:
California Agriculture, Vol 69, Iss 4 (2015)
Subsurface drip irrigation (SDI), because it can precisely deliver nutrients close to plant roots, could lead to carefully determined applications of fertilizer to meet crop needs and less risk of nitrate (NO3-) leaching to groundwater. Appropriate f
Externí odkaz:
https://doaj.org/article/df468f0eea2a4a6686e53feb0cc3d3c5
Autor:
Joseph D Mancias, Laura Pontano Vaites, Sahar Nissim, Douglas E Biancur, Andrew J Kim, Xiaoxu Wang, Yu Liu, Wolfram Goessling, Alec C Kimmelman, J Wade Harper
Publikováno v:
eLife, Vol 4 (2015)
NCOA4 is a selective cargo receptor for the autophagic turnover of ferritin, a process critical for regulation of intracellular iron bioavailability. However, how ferritinophagy flux is controlled and the roles of NCOA4 in iron-dependent processes ar
Externí odkaz:
https://doaj.org/article/5af6e8d673d04762ad593f5eaec09092
Autor:
Virginia Guarani, Elizabeth M McNeill, Joao A Paulo, Edward L Huttlin, Florian Fröhlich, Steven P Gygi, David Van Vactor, J Wade Harper
Publikováno v:
eLife, Vol 4 (2015)
The mitochondrial contact site and cristae junction (CJ) organizing system (MICOS) dynamically regulate mitochondrial membrane architecture. Through systematic proteomic analysis of human MICOS, we identified QIL1 (C19orf70) as a novel conserved MICO
Externí odkaz:
https://doaj.org/article/5ac2a4ae7c8f4bd1812e1dd92a7b85d6
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0129321 (2015)
Due to poor correlation between steady state mRNA levels and protein product, purely transcriptomic profiling methods may miss genes posttranscriptionally regulated by RNA binding proteins (RBPs) and microRNAs (miRNAs). RNA immunoprecipitation (RIP)
Externí odkaz:
https://doaj.org/article/09bf98a11dcc4e42b537eaf0ab308019
Autor:
Aaron C Ericsson, J Wade Davis, William Spollen, Nathan Bivens, Scott Givan, Catherine E Hagan, Mark McIntosh, Craig L Franklin
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0116704 (2015)
The commensal gut microbiota has been implicated as a determinant in several human diseases and conditions. There is mounting evidence that the gut microbiota of laboratory mice (Mus musculus) similarly modulates the phenotype of mouse models used to
Externí odkaz:
https://doaj.org/article/aa51e4ec109c4ccdb4484083cdb4f149