Zobrazeno 1 - 10
of 113
pro vyhledávání: '"J W Schrader"'
Publikováno v:
The Journal of Immunology. 159:5309-5317
We have investigated the activation of the p38 mitogen-activated protein kinase (MAPK) in normal mouse T and B cells and its role in apoptosis. Cross-linking of the CD3 chains of the TCR complex on proliferating T cells resulted in activation of p38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2d2b7bfec28fd1f5a33251a6c5e3381
https://doi.org/10.4049/jimmunol.159.11.5309
https://doi.org/10.4049/jimmunol.159.11.5309
Autor:
P C Orban, J W Schrader
Publikováno v:
The Journal of Immunology. 156:3334-3341
We show for the first time that Ab-mediated antagonism of growth factor activity can induce death of all cells in clonal populations surviving and growing by an autostimulatory mechanism. Models of autostimulatory leukemia were generated by transfect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aef8f6c6a8bc05449b930b3acd5b5e86
https://doi.org/10.4049/jimmunol.156.9.3334
https://doi.org/10.4049/jimmunol.156.9.3334
Publikováno v:
The Journal of Immunology. 151:6862-6871
p56lck, a member of the src family of non-receptor protein tyrosine kinases, is expressed almost exclusively in cells of lymphoid origin. p56lck is known to associate with the T lymphocyte surface glycoproteins CD4 and CD8, and plays a critical role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbf1f79de5ab75c065623a16c9ccbddc
https://doi.org/10.4049/jimmunol.151.12.6862
https://doi.org/10.4049/jimmunol.151.12.6862
Publikováno v:
The Journal of Immunology. 149:1683-1693
Stimulation of hemopoietic cells with IL-3, IL-4, IL-5, granulocyte-macrophage-CSF and Steel factor-(SLF) induced tyrosine phosphorylation of a number of protein substrates. Two of these proteins, designated p42 and p44, were tyrosine phosphorylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f852410a6c4371215b58cccf7131a63c
https://doi.org/10.4049/jimmunol.149.5.1683
https://doi.org/10.4049/jimmunol.149.5.1683
Publikováno v:
Blood. 78:1301-1310
WEHI-274.3 is a cell line isolated from an in vivo-derived, murine myelomonocytic leukemia. Although the survival and growth of WEHI-274.3 cells in vitro is absolutely dependent on the addition of exogenous growth factors such as interleukin-3 (IL-3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a36ac0d921c7efc928654eadb4a894
https://doi.org/10.1182/blood.v78.5.1301.bloodjournal7851301
https://doi.org/10.1182/blood.v78.5.1301.bloodjournal7851301
Publikováno v:
The Journal of Immunology. 146:3799-3808
Vascular smooth muscle cells were cultured from the mesenteric arteries of MRL lpr/lpr, MRL +/+, CBA/J, or C3H/HeJ mice and evaluated for their ability to synthesize a range of cytokines. Vascular smooth muscle cells of MRL +/+, MRL lpr/lpr, and CBA/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::894ce694913a85e0692e3a7b6ac961cc
https://doi.org/10.4049/jimmunol.146.11.3799
https://doi.org/10.4049/jimmunol.146.11.3799
Publikováno v:
The Journal of Immunology. 146:981-987
Mast cell-fibroblast interactions have been extensively investigated in the last few years. Fibroblasts support the in vitro survival but not proliferation of mouse connective-tissue type mast cells. However, the factor(s) that allow their survival o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::365104e1780725b27e1b0b9eefe2b8b8
https://doi.org/10.4049/jimmunol.146.3.981
https://doi.org/10.4049/jimmunol.146.3.981
Publikováno v:
European journal of immunology. 31(11)
The p38 mitogen-activated protein kinases (p38 MAPK) are activated in lymphocytes and acessory cells during innate and antigen-specific responses. We show that an inhibitor of two isoforms of p38 MAPK, SB 203580, inhibited the antigen-initiated produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fadfafbd7ab1fb6076545e55b00d15d6
https://pubmed.ncbi.nlm.nih.gov/11745338
https://pubmed.ncbi.nlm.nih.gov/11745338
Publikováno v:
Journal of lipid research. 42(9)
Oxidized LDL (oxLDL) is known to induce endothelial adhesion molecule and monocyte chemoattractant protein 1 expression and this is thought to be involved in monocyte recruitment into atherosclerotic lesions. oxLDL has also been found to induce macro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ada078a146941c83c3e6e4ec9bf71b4
https://pubmed.ncbi.nlm.nih.gov/11518769
https://pubmed.ncbi.nlm.nih.gov/11518769
Publikováno v:
Blood. 94(7)
M-Ras, a recently identified homologue of p21 Ras, is widely expressed, with levels of the 29-kD protein in spleen, thymus, and NIH 3T3 fibroblasts equaling or exceeding those of p21 Ras. A G22V mutant of M-Ras was constitutively active and its expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23bdd8d2da86dc3f4609300f06764d59
https://pubmed.ncbi.nlm.nih.gov/10498616
https://pubmed.ncbi.nlm.nih.gov/10498616