Zobrazeno 1 - 10
of 45
pro vyhledávání: '"J W Mier"'
Publikováno v:
The Journal of Immunology. 157:5653-5659
The adhesion molecule L-selectin (CD62L) is rapidly shed from the plasma membrane during leukocyte activation as a result of proteolytic cleavage between Lys321 and Ser322 within the extracellular domain. L-selectin is also down-modulated from the su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::370b7580cdae159dc6d9fc097a0c9a85
https://doi.org/10.4049/jimmunol.157.12.5653
https://doi.org/10.4049/jimmunol.157.12.5653
Publikováno v:
The Journal of Immunology. 152:3189-3198
The objectives of this study were to determine whether intensive immunotherapy with IL-2 results in detectable levels of circulating IL-1 and TNF antagonists and whether the levels achieved in vivo are sufficient to affect the generation of secondary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e63057e28e6f46bcbafe3aac85451de
https://doi.org/10.4049/jimmunol.152.6.3189
https://doi.org/10.4049/jimmunol.152.6.3189
Publikováno v:
Blood. 83:113-118
The aim of this study was to investigate whether interleukin (IL)-6 induces the production of IL-1 and tumor necrosis factor (TNF) antagonists. Serial plasma samples were obtained from cancer patients participating in phase I and II trials of recombi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df87cb6f203feedb1f8eaf5d6a7a790
https://doi.org/10.1182/blood.v83.1.113.bloodjournal831113
https://doi.org/10.1182/blood.v83.1.113.bloodjournal831113
Autor:
E V, Granowitz, R, Porat, J W, Mier, S F, Orencole, M V, Callahan, J G, Cannon, E A, Lynch, K, Ye, D D, Poutsiaka, E, Vannier
Publikováno v:
Blood. 82:2985-2990
Endotoxin is a component of gram-negative bacteria that causes hematologic and immunologic changes through its induction of cytokines. Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring inhibitor of IL-1 that competes with IL-1 for o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e549a66f6067241bf82c42faa68c1bb1
https://doi.org/10.1182/blood.v82.10.2985.bloodjournal82102985
https://doi.org/10.1182/blood.v82.10.2985.bloodjournal82102985
Publikováno v:
The Journal of Immunology. 151:3299-3307
The objective of this study was 1) to investigate the in vivo production of IL-8 in patients undergoing IL-2 immunotherapy and 2) to study the influence of IL-1Ra, soluble TNF receptor p75 (TNFsRp75), and a TNFsRp75-Fc fusion protein on IL-2-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87559dbe8c5e18a203e492c424eb25da
https://doi.org/10.4049/jimmunol.151.6.3299
https://doi.org/10.4049/jimmunol.151.6.3299
Autor:
E V Granowitz, R Porat, J W Mier, S F Orencole, G Kaplanski, E A Lynch, K Ye, E Vannier, S M Wolff, C A Dinarello
Publikováno v:
The Journal of Immunology. 151:1637-1645
When administered parenterally, endotoxin stimulates the synthesis of IL-1, TNF-alpha, and IL-6. However, this initial injection induces tolerance; a second injection of endotoxin results in lower levels of circulating cytokines. In our study, five h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee61074d5c20e0551d9aebb34bf77a8b
https://doi.org/10.4049/jimmunol.151.3.1637
https://doi.org/10.4049/jimmunol.151.3.1637
Publikováno v:
The Journal of Immunology. 150:4687-4692
This study was undertaken to determine whether IFN induce IL-1 receptor antagonist (IL-1Ra), a specific inhibitor of IL-1. Plasma samples were obtained from healthy volunteers (n = 5) and patients with chronic hepatitis C (n = 5) treated with IFN-alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3359542280c0ee37b3cf3c132723eab
https://doi.org/10.4049/jimmunol.150.10.4687
https://doi.org/10.4049/jimmunol.150.10.4687
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 12(11)
The antibiotic radicicol suppresses transformation in a variety of transformed cells. The antineoplastic effects of the drug have been attributed to the degradation of Raf and the inactivation of the Ras/Raf/mitogen-activated protein kinase kinase (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ec82ed30166130f321f17b5badaf6b5
https://pubmed.ncbi.nlm.nih.gov/11714635
https://pubmed.ncbi.nlm.nih.gov/11714635
Publikováno v:
Cancer chemotherapy and biological response modifiers. 19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dea3bc41068f1c0b2c2ac7b76f7a6704
https://pubmed.ncbi.nlm.nih.gov/11686023
https://pubmed.ncbi.nlm.nih.gov/11686023
Autor:
D F, McDermott, J W, Mier, D P, Lawrence, M R, van den Brink, M A, Clancy, K M, Rubin, M B, Atkins
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(6)
In an effort to develop a biochemotherapy regimen for metastatic melanoma suitable for testing in a cooperative group setting, we modified the concurrent biochemotherapy regimen of S. S. Legha et al. (J. Clin. Oncol., 16: 1752-1759, 1998) by providin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::626cfcbd845f07c1a0cc0e9a8f8fcdc3
https://pubmed.ncbi.nlm.nih.gov/10873069
https://pubmed.ncbi.nlm.nih.gov/10873069