Výsledky vyhledávání - "J W Kebabian"

Elektronická kniha

Cyclic Nucleotides : Part I: Biochemistry

The purpose of the present volume, the first of two on the pharmacology, biochemistry, and physiology of cyclic nucleotides, is to provide a comprehensive and up-to-date anthology on the nature and role of these important chemical regulators. Each of

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Phosphorylation of DARPP-32 and protein phosphatase inhibitor-1 in rat choroid plexus: regulation by factors other than dopamine

Autor: J. W. Kebabian, Paul Greengard, Gretchen L. Snyder, J. A. Nathanson, Jean-Antoine Girault, Andrew J. Czernik, J.-Y. C. Chen

Publikováno v: The Journal of Neuroscience. 12:3071-3083

The molecular mechanisms underlying regulation of fluid production by secretory epithelia such as the choroid plexus are poorly understood. Two cAMP-regulated inhibitors of protein phosphatase-1, inhibitor-1 (I1) and a dopamine- and cAMP-regulated ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c17ca22be139c982938fb669792d68
https://doi.org/10.1523/jneurosci.12-08-03071.1992

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Evidence for involvement of both D1 and D2 receptors in maintaining cocaine self-administration

Autor: J. Williams, D. Kerkman, Peter Curzon, D. R. Britton, R. G. MacKenzie, J. W. Kebabian

Publikováno v: Pharmacology Biochemistry and Behavior. 39:911-915

Rats trained to self-administer cocaine (0.75 mg/kg/infusion) on an FR-5 schedule were treated with selective D1 or D2 antagonists. A69045, a D1 antagonist with no appreciable affinity for 5-HT receptors increased cocaine self-administration to 147,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334e36432aab843d7edea4132203ee49
https://doi.org/10.1016/0091-3057(91)90052-4

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A68930: A Potent and Specific Agonist for the D-1 Dopamine Receptor

Autor: K. Asin, R. G. MacKenzie, R. Schoenleber, M. DeNinno, J. F. McKelvy, C. Briggs, D. R. Britton, J. W. Kebabian

Publikováno v: American Journal of Hypertension. 3:40S-42S

A68930 (5,6-dihydroxy-3-phenyl-1-aminomethyl-isochroman) is a potent (EC50 = 2.5 nmol/L) partial agonist at the D-1 dopamine receptor. In contrast, A68930 is a much weaker agonist (EC50 = 3,920 nmol/L) at the D-2 dopamine receptor. The orientation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e42363028cd68cbfb9680abcc3714b
https://doi.org/10.1093/ajh/3.6.40s

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A phosphorylation cascade in the basal ganglia of the mammalian brain: regulation by the D-1 dopamine receptor. A mathematical model of known biochemical reactions

Autor: J W, Kebabian

Publikováno v: Journal of neural transmission. Supplementum. 49

Stimulation of the dopamine D-1 receptor in the corpus striatum initiates a cascade of biochemical events. These events include: activation of adenylate cyclase, stimulation of cAMP-dependent protein kinase, protein phosphorylation and inhibition of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64a07a7e9e087c7a1a3bb0d6ff1bac43
https://pubmed.ncbi.nlm.nih.gov/9266424

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Differential effect of selective D-1 and D-2 dopamine receptor agonists on levodopa-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- exposed monkeys

Autor: P, Blanchet, P J, Bédard, D R, Britton, J W, Kebabian

Publikováno v: The Journal of pharmacology and experimental therapeutics. 267(1)

The motor effects of selective D-1 dopamine receptor stimulation in Parkinson's disease have been explored in a limited number of studies with partial D-1 agonists only and the results were unsatisfactory. Four 1-methyl-4-phenyl-1,2,3,6-tetrahydropyr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::160904ba1a75645623ceb0bbfce79267
https://pubmed.ncbi.nlm.nih.gov/7901395

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Multiple dopamine receptors and their implications in medicine

Autor: J W, Kebabian

Publikováno v: Current opinion in neurology and neurosurgery. 5(4)

Two categories of dopamine receptor were identified with classical pharmacological and biochemical techniques. Five different molecular species of dopamine receptor have been identified with molecular biological techniques. Each of the these five rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c3e98b3f521a5be587b0b3df44f9fc03
https://pubmed.ncbi.nlm.nih.gov/1387567

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[23] Production of phosphorylation state-specific antibodies

Autor: Jean-Antoine Girault, J.-Y. C. Chen, Andrew J. Czernik, J. W. Kebabian, Angus C. Nairn, Paul Greengard, Gretchen L. Snyder

Publisher Summary This chapter discusses the production of phosphorylation state-specific antibodies. The ability to detect and to quantitate changes in the state of phosphorylation of specific substrate proteins is of great utility in the study of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8d2b2bd78b3fc392bc0b69d1e545291
https://doi.org/10.1016/0076-6879(91)01025-w

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Biochemical Identification of the β-Adrenoceptor and Evidence for the Involvement of an Adenosine 3′,5′-Monophosphate System in the β-Adrenergically Induced Release of a-Melanocyte-Stimulating Hormone in the Intermediate Lobe of the Rat Pituitary Gland

Autor: T. COTE, M. MUNEMURA, R. L. ESKAY, J. W. KEBABIAN, WITH THE TECHNICAL ASSISTANCE OF R. LONG

Publikováno v: Endocrinology. 107:108-116

The beta-adrenoceptor in the intermediate lobe (IL) of the hypophysis of the rat is characterized on the basis of the following: 1) the ability of beta-adrenergic agonists to increase adenylate cyclase activity in homogenates of the IL, and 2) the ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2079105cda09c92da09f7bc62ccf6b
https://doi.org/10.1210/endo-107-1-108

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