Zobrazeno 1 - 10
of 48
pro vyhledávání: '"J W Kappler"'
Publikováno v:
The Journal of Immunology. 152:65-71
The commonly used strains of laboratory mice have mouse mammary tumor viruses (MTV) integrated at various locations in their DNA. The number and position of these integrants varies from one strain of mouse to another. It has recently been shown that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e92ccb1b905899895c798d23d712a827
https://doi.org/10.4049/jimmunol.152.1.65
https://doi.org/10.4049/jimmunol.152.1.65
Publikováno v:
The Journal of Immunology. 151:6657-6669
As mice age, spontaneous changes occur in the receptor repertoire of their T cells. The receptor repertoire of CD4+ T cells does not change with age. By contrast, however, the percentage of alpha beta+, CD8+ T cells bearing particular V elements vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab150aa3c4e6d8da3a8116f29c76a172
https://doi.org/10.4049/jimmunol.151.12.6657
https://doi.org/10.4049/jimmunol.151.12.6657
Publikováno v:
The Journal of Immunology. 144:2473-2479
The Staphylococcus aureus enterotoxins are known to be potent T cell activators, stimulating cell proliferation and lymphokine production. Two additional S. aureus proteins, exfoliating toxin and toxic shock syndrome toxin, share these properties. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e593da47ef134abb9056703f92685a30
https://doi.org/10.4049/jimmunol.144.7.2473
https://doi.org/10.4049/jimmunol.144.7.2473
Publikováno v:
Immunity. 11(4)
T cell activation requires engagement of the T cell receptor (TCR) at the interface of conjugates formed with antigen-presenting cells. TCR engagement is accompanied by a redistribution of specific signaling molecules to the cytoplasmic region of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6808d8e0bff18dbc75ec508c2d865e2b
https://pubmed.ncbi.nlm.nih.gov/10549623
https://pubmed.ncbi.nlm.nih.gov/10549623
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 94(2)
Engagement of alpha-beta T cell receptors (TCRs) induces many events in the T cells bearing them. The proteins that transduce these signals to the inside of cells are the TCR-associated CD3 polypeptides and zeta-zeta or zeta-eta dimers. Previous expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a1fdcc91d7e3a623d358cd2c77b3d38a
https://pubmed.ncbi.nlm.nih.gov/9012833
https://pubmed.ncbi.nlm.nih.gov/9012833
Publikováno v:
Progress in Immunology Vol. VIII ISBN: 9783642514814
T cell receptors for antigen bound to Major histocompatibility complex proteins (MHC) are made up of a number of different variable elements, Vα, Jα, V² and so on. Although any given mouse or man can probably make at least 1010 different versions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75d74f3ece995b406fd136c479b39baf
https://doi.org/10.1007/978-3-642-51479-1_8
https://doi.org/10.1007/978-3-642-51479-1_8
Autor:
H. McGrath, Andrew Herman, P. Marrack, L. N. Labrecque, R P Sékaly, J. Thidodeau, J. W. Kappler
Publikováno v:
T Lymphocytes ISBN: 9781461363323
Superantigens are a new class of antigen that stimulate a high proportion of T cells predominantly via the Vs element of the T cell receptor (TcR) (1–3). Two groups of superantigens have been described; they include the mouse self-superantigen enco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d36817293176bbc88be1cbe0cee5fd1
https://doi.org/10.1007/978-1-4615-3054-1_19
https://doi.org/10.1007/978-1-4615-3054-1_19
Publikováno v:
The Journal of Immunology. 130:781-784
Using murine splenic B cell preparations depleted of macrophages and rigorously depleted of T cells, we studied the role of nonspecific helper factors in in vitro antibody responses to T cell-independent (TI) type 1 and type 2 antigens. TNP-lipopolys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1cb1cc1c0fa320727894903fb087825
https://doi.org/10.4049/jimmunol.130.2.781
https://doi.org/10.4049/jimmunol.130.2.781
Publikováno v:
The Journal of Immunology. 142:3033-3037
V beta 3+ T cells are eliminated in Mls-2a mice carrying some, but not all, H-2 types. Analysis of AKXD and BXD recombinant inbred strains showed that Mls-2a (formerly Mlsc) was not the product of a single gene and suggested that at least two non-H-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d46be45c29b0af9ba3cdaaa2015d60b1
https://doi.org/10.4049/jimmunol.142.9.3033
https://doi.org/10.4049/jimmunol.142.9.3033
Publikováno v:
The Journal of Immunology. 141:3335-3341
We sought a quicker and easier method for the isolation of B cells enriched for a given Ag specificity. Here, we report our results using transgenic mice bearing mu- and kappa-transgenes that encode an IgR against the hapten phosphorylcholine. Spleni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::499c92a8335fb5036e23f83202d2d70c
https://doi.org/10.4049/jimmunol.141.10.3335
https://doi.org/10.4049/jimmunol.141.10.3335