Zobrazeno 1 - 10
of 28
pro vyhledávání: '"J W Kane"'
Autor:
Jonathan Middle, J W Kane
Publikováno v:
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 46:441-456
In this review we discuss the analytical inadequacies of oestradiol assays in relation to the clinical requirements for performing them, and make recommendations for their improvement. The measurement of oestradiol can be requested in a number of cli
Publikováno v:
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 43:196-199
Background: There are known difficulties in measuring testosterone in women using 'direct' (non-extraction) immunoassays. The positive bias encountered in many of these assays has been attributed to an unidentified interfering substance. We have eval
Publikováno v:
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 50:73-75
Background Measurement of fractionated plasma or urine metadrenalines is the recommended screening test in the diagnosis of phaeochromocytoma, with clinical cut-offs geared towards diagnostic sensitivity. Current practice at Salford Royal Hospital is
Publikováno v:
Clinical Endocrinology. 51:681-686
OBJECTIVE The possibility of the carbohydrate residues of glycoproteins affecting their recognition in immunoassays is an important and unresolved issue. This study looked for evidence of differential recognition of FSH glycoform preparations, of var
Autor:
J W Kane, A O Olukoga
Publikováno v:
Clinical Endocrinology. 51:119-126
OBJECTIVE The clinical characteristics and natural history of macroprolactinaemia are yet to be fully established and there is currently no widely accepted simple in vitro test for routine identification of the condition. This study was designed to f
Publikováno v:
Journal of the Royal Society of Medicine. 92:342-344
A woman with hirsutism but otherwise symptom-free was found to have a raised serum prolactin and a pituitary microadenoma. The hyperprolactinaemia persisted despite bromocriptine therapy and subsequent pituitary surgery, which yielded a non-functioni
Publikováno v:
Annals of clinical biochemistry. 44(Pt 1)
All immunoassays for female serum testosterone give falsely high results in some samples. The effect is variable and cannot be predicted for any given sample. Inaccurate calibration or interference by cross-reacting substances is almost certainly the
Autor:
A H Heald, N F Taylor, J W Kane, A Butterworth, A Rudenski, J Borzomato, Eric S. Kilpatrick, T Layton
Publikováno v:
Annals of clinical biochemistry. 43(Pt 3)
Background: Direct (non-extracted) testosterone immunoassays may give spuriously high results in women. The presumed interferents may be removed if testosterone is extracted into an organic phase before being measured. We aimed to clarify possible ca
Publikováno v:
Annals of clinical biochemistry. 40(Pt 5)
Adrenocorticotrophin (ACTH) is formed from the cleavage of pro-opiomelanocortin. Measurement of plasma ACTH is a key step in the differential diagnosis of hypothalamic-pituitary-adrenal disorders. Prior to the development of radioimmunoassay, the bio
Publikováno v:
Clinical endocrinology. 51(6)
The possibility of the carbohydrate residues of glycoproteins affecting their recognition in immunoassays is an important and unresolved issue. This study looked for evidence of differential recognition of FSH glycoform preparations, of variable isoe