IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death

Autor: Theresa L. Whiteside, Marta Szajnik, H Brandwein, Miroslaw J. Szczepanski, J W Hadden, J Han, K Signorelli, K Quadrini, Malgorzata Czystowska

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, 2009, 16 (5), pp.708-18. ⟨10.1038/cdd.2008.197⟩
Cell Death and Differentiation, Nature Publishing Group, 2009, 16 (5), pp.708-18. ⟨10.1038/cdd.2008.197⟩
Cell Death and Differentiation, Nature Publishing Group, 2009, 16 (5), pp.708-18. 〈10.1038/cdd.2008.197〉

International audience; IRX-2 is a cytokine-based biologic agent that has the potential to enhance antitumor immune responses. We investigated whether IRX-2 can protect T cells from tumor-induced apoptosis. Tumor-derived microvesicles (MV) expressing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4405aefc4179838cd033255d4555d7ba
https://doi.org/10.1038/cdd.2008.197

Immunostimulants

Autor: J W, Hadden

Publikováno v: Trends in Pharmacological Sciences. 14:169-174

Nonspecific immunostimulation has progressed from crude microbially derived substances to chemically defined drugs with selective effects on different components of the immune system. John Hadden describes how immunopharmacological analyses of struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698d30800465c05e9430fc5b9aeba162
https://doi.org/10.1016/0165-6147(93)90203-v

A pilot study of perilymphatic leukocyte cytokine mixture (IRX-2) as neoadjuvant treatment for early stage cervical carcinoma

Autor: A, Dueñas-Gonzalez, E, Verastegui, C, Lopez-Graniel, A, Gonzalez, A, Mota, J L, Barrera-Franco, A, Meneses, J, Chanona, J, de la Garza, A, Chavez-Blanco, J W, Hadden

Publikováno v: International immunopharmacology. 2(7)

Clinical and experimental data demonstrate that local cytokines are able to induce tumor regression and in some cases antitumor systemic immune response. IRX-2 is a cell-free mixture of cytokines obtained from unrelated donor lymphocytes with demonst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03d3bcc1b28cd4fadd15e8985a53077f
https://pubmed.ncbi.nlm.nih.gov/12188025

Immunomodulatory properties of Mycoplasma pulmonis. III. Lymphocyte stimulation and cytokine production by Mycoplasma pulmonis products

Autor: A, Romero-Rojas, J, Reyes-Esparza, S, Estrada-Parra, J W, Hadden

Publikováno v: International immunopharmacology. 1(9-10)

Experiments are presented that were performed in order to understand the mechanisms causing these effects on the immune system. Mitogenic effects of Mycoplasma membranes on mouse spleen cells were shown using M. capricolum. The observed mitogenic act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89058579455ff910ca0533624df67f42
https://pubmed.ncbi.nlm.nih.gov/11562062

The immunology and immunotherapy of breast cancer: an update

Autor: J W, Hadden

Publikováno v: International journal of immunopharmacology. 21(2)

Adenocarcinomas of the breast behave clinically and epidemiologically in ways that show host resistance factors are important for outcome in addition to grade and stage of malignancy. Immune reactivity to autologous tumors is indicated by the general

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87165cd467ef79c2f37746cdcec3545b
https://pubmed.ncbi.nlm.nih.gov/10230872