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Examination of the D2/5-HT2 affinity ratios of resolved 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: an enantioselective approach toward the design of potential atypical antipsychotics

Autor: J. W. Ferkany, L. S. Silverman, Bailey Ma, Carol Tiffany, M E Abreu, Carl Kaiser, Karbon Ew, Richard Eric Mewshaw, Mathew Rm

Publikováno v: Journal of Medicinal Chemistry. 36:3073-3076

Enantiomers of several N-substituted 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles were obtained by the resolution of 2-fluoro-5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole and 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indole followed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec5ee9589e41e0558cbdd8a60233291a
https://doi.org/10.1021/jm00073a005

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ChemInform Abstract: Examination of the D2/5-HT2 Affinity Ratios of Resolved 5,6,7,8,9,10- Hexahydro-7,10-iminocyclohept(b)indoles: An Enantioselective Approach Toward the Design of Potential Atypical Antipsychotics

Autor: Mathew Rm, J. W. Ferkany, Karbon Ew, Richard Eric Mewshaw, Bailey Ma, Carol Tiffany, Carl Kaiser, M E Abreu, L. S. Silverman

Publikováno v: ChemInform. 26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a7824f2d4c33985e3b062816a597446
https://doi.org/10.1002/chin.199503165

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NPC 205 is a potent and selective adenosine A1, receptor antagonist: Correlation among receptor binding, biochemical, and physiological assays

Autor: R. C. Hanson, J. R. Connor, R. H. Erickson, P. V. Kaplita, J. A. Schenden, R. P. Hicks, M. E. Abreu, L. Noronha‐Blob, J. W. Ferkany

Publikováno v: Drug Development Research. 20:429-443

The chemical synthesis of 8-aryl-1,3-dialkyl derivatives of xanthine and the ability of these compounds to interact with adenosine A1 and A2 receptors in vitro (in receptor binding, biochemical, and physiological assays) are described. NPC 205 (1,3-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f0e43833cff00988a15dbab5831263a
https://doi.org/10.1002/ddr.430200403

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Behavioral pharmacology of NPC 17742, a competitive N-methyl-D-aspartate (NMDA) antagonist

Autor: J, Willetts, D B, Clissold, T L, Hartman, R R, Brandsgaard, G S, Hamilton, J W, Ferkany

Publikováno v: The Journal of pharmacology and experimental therapeutics. 265(3)

The behavioral effects of the competitive N-methyl-D-aspartate (NMDA) antagonist 2R,4R,5S-2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoate (NPC 17742) were compared with those of its parent compound, 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28c3ae491fbd81b79e2b14a903f53b05
https://pubmed.ncbi.nlm.nih.gov/8099615

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Pharmacological profile of NPC 17742 [2R,4R,5S-(2-amino-4,5-(1, 2-cyclohexyl)-7-phosphonoheptanoic acid)], a potent, selective and competitive N-methyl-D-aspartate receptor antagonist

Autor: J W, Ferkany, G S, Hamilton, R J, Patch, Z, Huang, S A, Borosky, D L, Bednar, B E, Jones, R, Zubrowski, J, Willetts, E W, Karbon

Publikováno v: The Journal of pharmacology and experimental therapeutics. 264(1)

2R,4R,5S-(2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid) (NPC 17742), the most potent isomer of the mixture 2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (NPC 12626), was evaluated for activity in tests associated with receptors for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2190cbd201a7f488775eef68f8869ba4
https://pubmed.ncbi.nlm.nih.gov/8423528

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N-methyl-D-aspartate antagonists and working memory performance: comparison with the effects of scopolamine, propranolol, diazepam, and phenylisopropyladenosine

Autor: M J, Pontecorvo, D B, Clissold, M F, White, J W, Ferkany

Publikováno v: Behavioral neuroscience. 105(4)

The effects of the competitive N-methyl-D-aspartate (NMDA) antagonists CPP (510 mg/kg) and NPC 12626 (2540 mg/kg) and the noncompetitive NMDA antagonists phencyclidine (1, 3,6.25 mg/kg) and MK 801 (0.10.2 mg/kg) on performance of rats on a nonspatial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b7b2152cff2bdc7679f2b85f0f445b1
https://pubmed.ncbi.nlm.nih.gov/1657031

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Kainic acid selectively stimulates the release of endogenous excitatory acidic amino acids

Autor: J W, Ferkany, J T, Coyle

Publikováno v: The Journal of pharmacology and experimental therapeutics. 225(2)

Kainic acid (KA) exhibits both neuroexcitatory and neurotoxic actions when applied to the brain. Whereas the neuroexcitatory actions are direct, the neurotoxic effects require the integrity of excitatory afferents. In addition, specific receptors for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0dd052575c26a53593b2cee1a95d82d
https://pubmed.ncbi.nlm.nih.gov/6842403

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Kainic acid: insights from a neurotoxin into the pathophysiology of Huntington's disease

Autor: J T, Coyle, J W, Ferkany, R, Zaczek

Publikováno v: Neurobehavioral toxicology and teratology. 5(6)

Kainic acid, a conformationally restricted analog of L-glutamic acid, is a potent neuroexcitant. Consistent with the excitotoxin hypothesis of Olney, intrastriatal injection of kainic acid causes degeneration of neurons with perikarya within the stri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9457d6292999a4ff0dc0c0d747cc663f
https://pubmed.ncbi.nlm.nih.gov/6142425

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