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PM-3, a benzo-gamma-pyran derivative isolated from propolis, inhibits growth of MCF-7 human breast cancer cells

Autor: J, Luo, J W, Soh, W Q, Xing, Y, Mao, T, Matsuno, I B, Weinstein

Publikováno v: Anticancer research. 21(3B)

Propolis has numerous biologic activities including antibiotic, antifungal, antiviral and anti-inflammatory properties. Several components isolated from propolis have been shown to have anticancer activity. This study demonstrates that the compound P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::61f44ce6830a577c287fe484952b2498
https://pubmed.ncbi.nlm.nih.gov/11497245

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Antiproliferative effects of S-allylmercaptocysteine on colon cancer cells when tested alone or in combination with sulindac sulfide

Autor: H, Shirin, J T, Pinto, Y, Kawabata, J W, Soh, T, Delohery, S F, Moss, V, Murty, R S, Rivlin, P R, Holt, I B, Weinstein

Publikováno v: Cancer research. 61(2)

Epidemiological studies link increased garlic (Allium sativum) consumption with a reduced incidence of colon cancer in various human populations. Experimental carcinogenesis studies in animal models and in cell culture systems indicate that several a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::557a61bba60d51ed26e05849f2f82aba
https://pubmed.ncbi.nlm.nih.gov/11212275

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Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1

Autor: J W, Soh, Y, Mao, M G, Kim, R, Pamukcu, H, Li, G A, Piazza, W J, Thompson, I B, Weinstein

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(10)

Sulindac sulfone (Exisulind) induces apoptosis and exhibits cancer chemopreventive activity, but in contrast to sulindac, it does not inhibit cyclooxygenases 1 or 2. We found that sulindac sulfone and two potent derivatives, CP248 and CP461, inhibite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2dec8a1ebaf4b34fb3db4bff8afafd8f
https://pubmed.ncbi.nlm.nih.gov/11051267

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Overexpression of p21Cip1 or p27Kip1 in the promyelocytic leukemia cell line HL60 accelerates its lineage-specific differentiation

Autor: P, Zhou, Y, Yao, J W, Soh, I B, Weinstein

Publikováno v: Anticancer research. 19(6B)

The process of terminal differentiation is associated with exit from the cell cycle and loss of the proliferative potential of cells. The cyclin-dependent kinase inhibitors (CDIs) play critical roles in check-point functions during the cell cycle and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e0d92c653d9a74125a6c93e1b0e7e1e6
https://pubmed.ncbi.nlm.nih.gov/10697493

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Overexpression of protein kinase C-beta1 isoenzyme suppresses indomethacin-induced apoptosis in gastric epithelial cells

Autor: IB Weinstein, G.H. Zhu, Shiu Kum Lam, ED Slosberg, M C Eggo, Benjamin C.Y. Wong, K C Lai, C K Ching, S T Yuen, J W Soh

Publikováno v: Gastroenterology. 118(3)

Background & Aims: We have previously reported that nonsteroidal anti-inflammatory drugs (NSAIDs) could induce apoptosis of gastric epithelial cells both in vivo and in vitro. This study investigated the role of protein kinase C (PKC) isoforms in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe03791933f35702965769e0cd7285c
https://pubmed.ncbi.nlm.nih.gov/10702201

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Overexpression of p27Kip1 inhibits the growth of both normal and transformed human mammary epithelial cells

Autor: A, Sgambato, Y J, Zhang, M, Ciaparrone, J W, Soh, A, Cittadini, R M, Santella, I B, Weinstein

Publikováno v: Cancer research. 58(15)

We previously reported increased expression of p27Kip1 in a series of human breast cancer cell lines, as compared to cell lines established from normal mammary epithelial cells. These data were surprising because this protein exerts a growth-inhibito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::635419411eda00da8b625aab3c927a18
https://pubmed.ncbi.nlm.nih.gov/9699679

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Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis

Autor: E K, Han, M, Begemann, A, Sgambato, J W, Soh, Y, Doki, W Q, Xing, W, Liu, I B, Weinstein

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 7(6)

Cyclin D1 is frequently amplified and/or overexpressed in human breast cancer and several other types of cancer. To examine the role of cyclin D1 in normal mammary epithelial cells, in the present study we have overexpressed human cyclin D1 in the mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75d8020da3a79bb53ad68600d7bf34d6
https://pubmed.ncbi.nlm.nih.gov/8780883

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