Výsledky vyhledávání - "J W, Paschal"

Microbial process for preparation of glucuronides of raloxifene

Autor: J W Paschal, Barbara Shreve Briggs, P J Baker, B G Getman, Muth William Lawrence, Robert J. Strobel, Milton J. Zmijewski, Matthew D. Belvo, C A J Kemp, Thomas J. Perun, T D Black

Publikováno v: Journal of Industrial Microbiology and Biotechnology. 23:194-197

Raloxifene, also known as Evista®, has recently been approved for the prevention of osteoporosis. Three glucuronidated compounds: raloxifene-6-glucuronide, raloxifene-27-glucuronide, and raloxifene-6,27-diglucuronide are known metabolites of raloxif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fafee61f988080817d8322d47811a0d9
https://doi.org/10.1038/sj.jim.2900716

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Synthesis and structure-activity relationships of new 9-N-alkyl derivatives of 9(S)-erythromycylamine

Autor: H A, Kirst, J A, Wind, J P, Leeds, K E, Willard, M, Debono, R, Bonjouklian, J M, Greene, K A, Sullivan, J W, Paschal, J B, Deeter

Publikováno v: Journal of Medicinal Chemistry. 33:3086-3094

A series of new 9-N-alkyl derivatives of 9(S)-erythromycylamine has been synthesized by reductive alkylation of erythromycylamine with aliphatic aldehydes and sodium cyanoborohydride. Alternative syntheses employing hydrogenation methods have also be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633b1eb921c977519886960bc5c8af08
https://doi.org/10.1021/jm00173a028

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In vitro biotransformation and identification of human cytochrome P450 isozyme-dependent metabolism of tazofelone

Autor: S S, Surapaneni, M P, Clay, L A, Spangle, J W, Paschal, T D, Lindstrom

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 25(12)

Tazofelone is a new inflammatory bowel disease agent. The biotransformation of tazofelone in human livers and the cytochrome P450 responsible for the biotransformation has been studied. Two metabolites of tazofelone were formed in vitro. A sulfoxide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::981a91c80e47d322ba52f49f72bdb722
https://pubmed.ncbi.nlm.nih.gov/9394028

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Aqueous acidic degradation of the carbacephalosporin loracarbef

Autor: M J, Skibic, K W, Taylor, J L, Occolowitz, M W, Collins, J W, Paschal, L J, Lorenz, L A, Spangle, D E, Dorman, S W, Baertschi

Publikováno v: Journal of pharmaceutical sciences. 82(10)

The aqueous degradation of the carbacephalosporin loracarbef under moderately acidic conditions (pH range, 2.7-4.3) is described. Structures of a total of 10 compounds isolated by preparative reversed-phase HPLC have been proposed. Five of these 10 d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::13a36da2c389591d1e79d3e653750ee5
https://pubmed.ncbi.nlm.nih.gov/8254485

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