Výsledky vyhledávání - "J W, Nalwalk"

Inhibition of improgan antinociception by the cannabinoid (CB)(1) antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A): lack of obligatory role for endocannabinoids acting at CB(1) receptors

Autor: L B, Hough, J W, Nalwalk, R, Stadel, H, Timmerman, R, Leurs, B C, Paria, X, Wang, S K, Dey

Publikováno v: The Journal of pharmacology and experimental therapeutics. 303(1)

Improgan, a nonopioid antinociceptive agent, activates descending, pain-relieving mechanisms in the brain stem, but the receptor for this compound has not been identified. Because cannabinoids also activate nonopioid analgesia by a brain stem action,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::523cb571cfd7fe91234216fff96bcf57
https://pubmed.ncbi.nlm.nih.gov/12235266

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Novel qualitative structure-activity relationships for the antinociceptive actions of H2 antagonists, H3 antagonists and derivatives

Autor: L B, Hough, J W, Nalwalk, B Y, Li, R, Leurs, W M, Menge, H, Timmerman, M E, Carlile, C, Cioffi, M, Wentland

Publikováno v: The Journal of pharmacology and experimental therapeutics. 283(3)

Recent studies have shown that cimetidine, burimamide and improgan (also known as SKF92374, a cimetidine congener lacking H2 antagonist activity) induce antinociception after intracerebroventricular administration in rodents. Because these substances

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::984dc92fc7edbc5a6b2ca1bf0f6d3c55
https://pubmed.ncbi.nlm.nih.gov/9400031

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Characterization of the antinociceptive properties of cimetidine and a structural analog

Autor: B Y, Li, J W, Nalwalk, L A, Barker, P, Cumming, M E, Parsons, L B, Hough

Publikováno v: The Journal of pharmacology and experimental therapeutics. 276(2)

The antinociceptive and pharmacological properties of the H2 receptor antagonist cimetidine and a novel cimetidine analog, SKF92374, were characterized. On both the hot-plate and tail-flick nociceptive tests, cimetidine and SKF92374 induced complete,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2c74c821b7381bf5fd955d1392b36c29
https://pubmed.ncbi.nlm.nih.gov/8632315

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Pharmacological characterization of GT-2016, a non-thiourea-containing histamine H3 receptor antagonist: in vitro and in vivo studies

Autor: C E, Tedford, S L, Yates, G P, Pawlowski, J W, Nalwalk, L B, Hough, M A, Khan, J G, Phillips, G J, Durant, R C, Frederickson

Publikováno v: The Journal of pharmacology and experimental therapeutics. 275(2)

GT-2016, a non-thiourea-containing imidazole, has been developed as a histamine H3 antagonist. In vitro and in vivo studies in rats were conducted to characterize receptor selectivity and autoreceptor functionality for GT-2016. GT-2016 demonstrated h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::777045529743ae4834ede59cca29f7b2
https://pubmed.ncbi.nlm.nih.gov/7473144

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alpha-Fluoromethylhistidine-induced inhibition of brain histidine decarboxylase. Implications for the CO2-trapping enzymatic method

Autor: J J, Skratt, L B, Hough, J W, Nalwalk, K E, Barke

Publikováno v: Biochemical pharmacology. 47(2)

The actions of S-alpha-fluoromethylhistidine (FMH), an irreversible inhibitor of the histamine biosynthetic enzyme histidine decarboxylase (HD), were studied on rat brain HD, as measured by a recently developed CO2-trapping enzymatic method. As expec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2d87a7fbc00aedad0ae6e64cb2da48c0
https://pubmed.ncbi.nlm.nih.gov/8304983

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