Zobrazeno 1 - 10
of 271
pro vyhledávání: '"J W, Lown"'
Publikováno v:
Photochemistry and Photobiology. 48:19-25
— The 1,4-diamino-substituted anthraquinones mitoxantrone and ametantrone do not photosensitize DNA damage following illumination with visible light. In contrast, both the 1,5- and 1,8-bis[[(diethylamino)ethyl]amino]anthraquinones, AMI and AM2 resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f09c6e1d8f99142afaafe4f84b774d
https://doi.org/10.1111/j.1751-1097.1988.tb02781.x
https://doi.org/10.1111/j.1751-1097.1988.tb02781.x
Autor:
Günther Burckhardt, Leonhard Kittler, H. Simon, Zimmer C, Sanjay K. Sharma, J. W. Lown, Eckhard Birch-Hirschfeld
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 19:1101-1109
The binding ability of cross-linked thiazolated polyamides (containing the base sequence-reading elements thiazole(Th)-pyrrole(Py)-pyr-role(Py) and thiazole(Th)-imidazole(Im)- pyrrol(Py) to various DNA dodecamers has been investigated. CD titration e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7a65dab025a23dcaad86edb7ebe981e
https://doi.org/10.1080/07391102.2002.10506813
https://doi.org/10.1080/07391102.2002.10506813
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 174:81-92
The reactions of substituted o-phenylene diamines, o-aminophenol, o-aminothiophenol, 3,4-diaminopyridine with p-cyanobenzaldehyde by refluxing in nitrobenzene gave corresponding benzimidazole, benzoxazole, benzthiazole and imidazopyridine derivatives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::650f368e9d717e8d907f018adfe39ed0
https://doi.org/10.1080/10426500108040234
https://doi.org/10.1080/10426500108040234
Publikováno v:
The Journal of Organic Chemistry. 66:1030-1034
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9396f89c7760bd00476e44e70cffbe
https://doi.org/10.1021/jo001034s
https://doi.org/10.1021/jo001034s
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 18:423-431
AM1 semi-empirical and ab initio calculations were performed on certain synthetic polyamide conjugates of the aglycone of the minor groove binding antibiotic calicheamicin. Geometry optimized conformations and heats of formation were obtained. The bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a48b8758ff143a3123f910c72546689
https://doi.org/10.1080/07391102.2000.10506678
https://doi.org/10.1080/07391102.2000.10506678
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 15:81-95
Binding to DNA and synthetic duplex polymers of two bifunctional netropsins and effects on supercoiled plasmid DNA as well as their inhibitory potency on DNA topoisomerases have been investigated. Characteristic differences were found in the DNA bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985341c9aeccbfc0d4be1a083ba9e2d6
https://doi.org/10.1080/07391102.1997.10508948
https://doi.org/10.1080/07391102.1997.10508948
Autor:
J. W. Lown
Publikováno v:
Canadian Journal of Chemistry. 75:99-119
Photodynamic therapy relies on the selective accumulation of photosensitizers within neoplastic tissue, followed by light activation to generate cytotoxic singlet oxygen. At present, PhotofrinTM, a preparation of hematoporphyrin derivatives (HPD) wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79ae75fb4d30cfc9fa30e74933154741
https://doi.org/10.1139/v97-015
https://doi.org/10.1139/v97-015
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 14:475-484
Ab initio calculations (Hartree-Fock) using the 3–21G and the STO-3G Gaussian basis sets were performed on synthetic analogues of the minor groove binding bis-benzimidazole Hoechst 33258 designed to exhibit altered sequence recognition. Geometry op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cc5ad3171c096c05266405b8d114b5
https://doi.org/10.1080/07391102.1997.10508146
https://doi.org/10.1080/07391102.1997.10508146
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 13:553-564
The understanding of early events in the expression of genes has vastly improved in recent years with the identification of a variety of gene- and sequence-specific DNA binding transcription factors. One such protein, Sp1, has been implicated in acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dd97885db3891a74fd6675c6f37af8
https://doi.org/10.1080/07391102.1995.10508866
https://doi.org/10.1080/07391102.1995.10508866
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 13:269-284
The asymmetrical DNA duplex [5'd(AAGGGACTTTCC)].[5'-d(GGAAAGTCCCTT)] has been studied by one- and two-dimensional NMR techniques. The sequence is comprised of the actual 10 base-pair long binding site for the transcription factor NF-kappa B in the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d3c4317a475f6631effeaf97fbd65f
https://doi.org/10.1080/07391102.1995.10508839
https://doi.org/10.1080/07391102.1995.10508839